XGEA_ASPFC
ID XGEA_ASPFC Reviewed; 238 AA.
AC B0XNQ1;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Probable xyloglucan-specific endo-beta-1,4-glucanase A;
DE EC=3.2.1.151;
DE AltName: Full=Xyloglucanase A;
DE AltName: Full=Xyloglucanendohydrolase A;
DE Flags: Precursor;
GN Name=xgeA; ORFNames=AFUB_005070;
OS Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=451804;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Catalyzes endohydrolysis of 1,4-beta-D-glucosidic linkages in
CC xyloglucan with retention of the beta-configuration of the glycosyl
CC residues. Specific for xyloglucan and does not hydrolyze other cell
CC wall components (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=xyloglucan + H2O = xyloglucan oligosaccharides.; EC=3.2.1.151;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 12 (cellulase H) family.
CC {ECO:0000305}.
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DR EMBL; DS499594; EDP55811.1; -; Genomic_DNA.
DR AlphaFoldDB; B0XNQ1; -.
DR SMR; B0XNQ1; -.
DR EnsemblFungi; EDP55811; EDP55811; AFUB_005070.
DR VEuPathDB; FungiDB:AFUB_005070; -.
DR HOGENOM; CLU_051064_0_1_1; -.
DR PhylomeDB; B0XNQ1; -.
DR Proteomes; UP000001699; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008810; F:cellulase activity; IEA:InterPro.
DR GO; GO:0033946; F:xyloglucan-specific endo-beta-1,4-glucanase activity; IEA:UniProtKB-EC.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.180; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR013319; GH11/12.
DR InterPro; IPR002594; GH12.
DR PANTHER; PTHR34002; PTHR34002; 1.
DR Pfam; PF01670; Glyco_hydro_12; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Cell wall biogenesis/degradation; Glycoprotein;
KW Glycosidase; Hydrolase; Polysaccharide degradation; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..238
FT /note="Probable xyloglucan-specific endo-beta-1,4-glucanase
FT A"
FT /id="PRO_0000394070"
FT CARBOHYD 106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 171
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 238 AA; 25298 MW; F5BD872BA21F4645 CRC64;
MKLSLSVALS LAAATAQAAT QFCDQWGSVT EGNYILYNNL WGQAQATSGS QCTTFESLSG
NTIVWNTKWS WSGGQGQVKS FANAALQFTP KKLSSVKSID STWKWNYSGS NIVADVAYDM
FLSTSPGGDH NYEIMVWLGA LGGAGPISST GSPIATPTVA GIKFNLYLGP NGSMQVYSFV
AQSTTNSFSG DMRDFFTYLE SNQGLSSDLY LVDVQAGTEP FSGSNAVFTV SDYSVSVA
