CAP1_DICDI
ID CAP1_DICDI Reviewed; 333 AA.
AC P19198; C7FZY9; Q556I8; Q558M3; Q86K11;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=cAMP-binding protein 1;
DE Short=CABP-1;
GN Name=capA-1; Synonyms=cabP1; ORFNames=DDB_G0272560;
GN and
GN Name=capA-2; Synonyms=cabP1; ORFNames=DDB_G0274023;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
RC STRAIN=AX3;
RX PubMed=2176639; DOI=10.1016/0378-1119(90)90255-p;
RA Grant C., Tsang A.;
RT "Cloning and characterization of cDNAs encoding a novel cyclic AMP-binding
RT protein in Dictyostelium discoideum.";
RL Gene 96:213-218(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CAPA-1), AND ALTERNATIVE SPLICING.
RC STRAIN=AX2;
RX PubMed=2216719; DOI=10.1093/nar/18.18.5457;
RA Grant C.E., Bain G., Tsang A.;
RT "The molecular basis for alternative splicing of the CABP1 transcripts in
RT Dictyostelium discoideum.";
RL Nucleic Acids Res. 18:5457-5463(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CAPA-1), AND VARIANT 99-GLN--PRO-107
RP DEL.
RC STRAIN=V12M2;
RX PubMed=1989693; DOI=10.1016/0167-4781(91)90165-i;
RA Bonfils C., Hebert J., Tsang A.;
RT "A 27-bp deletion is responsible for the expression of a variant CABP1, a
RT cyclic AMP-binding protein of Dictyostelium discoideum.";
RL Biochim. Biophys. Acta 1088:145-146(1991).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (CAPA-1 AND CAPA-2).
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (CAPA-1 AND CAPA-2).
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBUNIT: Heterodimer of CABP1A and CABP1B. CABP1A/CABP1B could also
CC associate with p31/p34 to form an active complex.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A; Synonyms=CABP1A;
CC IsoId=P19198-1; Sequence=Displayed;
CC Name=B; Synonyms=CABP1B;
CC IsoId=P19198-2; Sequence=VSP_000758;
CC -!- SIMILARITY: Belongs to the CAPAB/TerDEXZ family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; M36176; AAA33173.1; -; mRNA.
DR EMBL; X52688; CAA36913.1; -; Genomic_DNA.
DR EMBL; X52688; CAB38633.1; -; Genomic_DNA.
DR EMBL; X55975; CAA39445.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70916.1; -; Genomic_DNA.
DR EMBL; AAFI02000009; EAL70917.1; -; Genomic_DNA.
DR EMBL; AAFI02000011; EAL70445.1; -; Genomic_DNA.
DR EMBL; AAFI02000011; EEU04131.1; -; Genomic_DNA.
DR PIR; S11484; S11484.
DR PIR; S13497; S13497.
DR RefSeq; XP_002649183.1; XM_002649137.1.
DR RefSeq; XP_644370.1; XM_639278.1.
DR RefSeq; XP_645043.1; XM_639951.1.
DR RefSeq; XP_645044.1; XM_639952.1.
DR AlphaFoldDB; P19198; -.
DR SMR; P19198; -.
DR PaxDb; P19198; -.
DR EnsemblProtists; EAL70445; EAL70445; DDB_G0274023.
DR EnsemblProtists; EAL70916; EAL70916; DDB_G0272560.
DR EnsemblProtists; EAL70917; EAL70917; DDB_G0272560.
DR EnsemblProtists; EEU04131; EEU04131; DDB_G0274023.
DR GeneID; 8618720; -.
DR GeneID; 8619256; -.
DR KEGG; ddi:DDB_G0272560; -.
DR KEGG; ddi:DDB_G0274023; -.
DR dictyBase; DDB_G0272560; capA-1.
DR dictyBase; DDB_G0274023; capA-2.
DR eggNOG; ENOG502SAWS; Eukaryota.
DR HOGENOM; CLU_941427_0_0_1; -.
DR InParanoid; P19198; -.
DR PhylomeDB; P19198; -.
DR PRO; PR:P19198; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0009986; C:cell surface; IDA:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0005634; C:nucleus; IDA:dictyBase.
DR GO; GO:0030552; F:cAMP binding; IDA:dictyBase.
DR CDD; cd06974; TerD_like; 1.
DR InterPro; IPR003325; TerD.
DR Pfam; PF02342; TerD; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; cAMP; cAMP-binding; Nucleotide-binding;
KW Reference proteome; Repeat.
FT CHAIN 1..333
FT /note="cAMP-binding protein 1"
FT /id="PRO_0000170775"
FT REPEAT 48..52
FT /note="A-1"
FT REPEAT 67..71
FT /note="A-2"
FT REPEAT 79..83
FT /note="A-3"
FT REPEAT 84..95
FT /note="B-1"
FT REPEAT 87..95
FT /note="C-1"
FT REPEAT 96..107
FT /note="B-2"
FT REPEAT 99..107
FT /note="C-2"
FT REPEAT 108..116
FT /note="C-3"
FT REPEAT 117..125
FT /note="C-4"
FT REPEAT 126..134
FT /note="C-5"
FT REGION 1..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..83
FT /note="3 X 5 AA repeats of motif A"
FT REGION 84..107
FT /note="2 X 12 AA repeats of motif B"
FT REGION 87..134
FT /note="5 X 9 AA repeats of motif C"
FT COMPBIAS 1..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..83
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 12..48
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_000758"
FT VARIANT 99..107
FT /note="Missing (in variant V12M2)"
FT /evidence="ECO:0000269|PubMed:1989693"
FT CONFLICT 312..322
FT /note="FVAVGKGMQGA -> LLLLVKVCKAF (in Ref. 1; AAA33173 and
FT 2; CAB38633/CAA36913)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 333 AA; 35339 MW; 864B3AA2D2FBFC02 CRC64;
MYNPPPPSGS QGNNNYYRQP SSTPGVSNPN PQANQFLPPQ PSNTTQTPGG YPPQQQQRPP
TGAPQQPGGY PTPPPPGAPG GYPPQQQPAG QYGAPPQQQP AGQYGAPQPA GQYGAPQPAG
QYGAPQPAGQ YGAPPPPPGG AGISLVKNQQ ISLTKEDPTL RKLTIGLGWD VNTTPTAPFD
LDAVVFMLNA QGRVRTSQDF IFYNNKVSRD NSVSHQGDNL TGQGEGDDEV VLVNLQAVSP
DVTRLVFAVT IHLADERRQN FTMVPRAFIR VANQETGRNI CRYDLSQEGG PNTALIAGEV
YRDPSNPNNW SFVAVGKGMQ GALPGLLQIF GCQ
