CAP1_PIG
ID CAP1_PIG Reviewed; 233 AA.
AC P40125;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 25-MAY-2022, entry version 99.
DE RecName: Full=Adenylyl cyclase-associated protein 1;
DE Short=CAP 1;
DE AltName: Full=ASP-56 protein;
DE Flags: Fragments;
GN Name=CAP1; Synonyms=CAP;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Platelet;
RX PubMed=1544438; DOI=10.1016/0014-5793(92)80043-g;
RA Gieselmann R., Mann K.;
RT "ASP-56, a new actin sequestering protein from pig platelets with homology
RT to CAP, an adenylate cyclase-associated protein from yeast.";
RL FEBS Lett. 298:149-153(1992).
CC -!- FUNCTION: Directly regulates filament dynamics and has been implicated
CC in a number of complex developmental and morphological processes,
CC including mRNA localization and the establishment of cell polarity.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Binds actin monomers (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CAP family. {ECO:0000305}.
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DR PeptideAtlas; P40125; -.
DR PRIDE; P40125; -.
DR InParanoid; P40125; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0008179; F:adenylate cyclase binding; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR GO; GO:0019933; P:cAMP-mediated signaling; IBA:GO_Central.
DR GO; GO:0000902; P:cell morphogenesis; IBA:GO_Central.
DR GO; GO:0045761; P:regulation of adenylate cyclase activity; IBA:GO_Central.
DR Gene3D; 2.160.20.70; -; 1.
DR InterPro; IPR001837; Adenylate_cyclase-assoc_CAP.
DR InterPro; IPR013912; Adenylate_cyclase-assoc_CAP_C.
DR InterPro; IPR016098; CAP/MinC_C.
DR InterPro; IPR028415; CAP1.
DR InterPro; IPR036223; CAP_C_sf.
DR PANTHER; PTHR10652; PTHR10652; 2.
DR PANTHER; PTHR10652:SF1; PTHR10652:SF1; 2.
DR Pfam; PF08603; CAP_C; 1.
DR SUPFAM; SSF69340; SSF69340; 1.
DR PROSITE; PS01089; CAP_2; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Cell membrane; Direct protein sequencing; Isopeptide bond;
KW Membrane; Methylation; Phosphoprotein; Reference proteome; Ubl conjugation.
FT CHAIN <1..>233
FT /note="Adenylyl cyclase-associated protein 1"
FT /id="PRO_0000205698"
FT DOMAIN <173..221
FT /note="C-CAP/cofactor C-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00659"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 43..128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..99
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 14
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:P40124"
FT MOD_RES 17
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q01518"
FT MOD_RES 101
FT /note="N6-methyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q01518"
FT MOD_RES 104
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q01518"
FT MOD_RES 115
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q01518"
FT MOD_RES 122
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q01518"
FT MOD_RES 124
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q01518"
FT CROSSLNK 151
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO1)"
FT /evidence="ECO:0000250|UniProtKB:Q01518"
FT NON_CONS 20..21
FT /evidence="ECO:0000305"
FT NON_CONS 38..39
FT /evidence="ECO:0000305"
FT NON_CONS 45..46
FT /evidence="ECO:0000305"
FT NON_CONS 68..69
FT /evidence="ECO:0000305"
FT NON_CONS 130..131
FT /evidence="ECO:0000305"
FT NON_CONS 151..152
FT /evidence="ECO:0000305"
FT NON_CONS 172..173
FT /evidence="ECO:0000305"
FT NON_TER 1
FT NON_TER 233
SQ SEQUENCE 233 AA; 25079 MW; F9D022193D150698 CRC64;
LEAVSHASDT HYGYGDSAAK EIGGDVLKHA EMVHTGLKEY KDVDKXGPVA KELSGLPSGP
SAGSGPPPSA LFAQIHQGES ITHALKHVAD DEKTHKNPAD KAQSGPVRXG PKPFSASKPG
ISPSPKPVTK KWRXENXENV SNLVIDDTEL KSVNSTLQIK XXINSISVDN YKVPXISINK
XDGRHIYLSK NSLDCEIVSA KSSEMNVLIP TEGGDFNEFP VPEQXKXIWN GQK
