ID   XHLB_BACSU              Reviewed;          87 AA.
AC   Q99163;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Holin;
GN   Name=xhlB; Synonyms=xpaB; OrderedLocusNames=BSU12800;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=2033382; DOI=10.1099/00221287-137-3-667;
RA   Lee J.W.K., Edwards C.W., Hulett F.M.;
RT   "Identification of four unique clones encoding 10 kDa proteins from
RT   Bacillus that cause phenotypic complementation of a phoA mutant strain of
RT   Escherichia coli.";
RL   J. Gen. Microbiol. 137:667-677(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168 / SO113;
RA   Krogh S., Joergensen S.T., Diderichsen B., Devine K.M.;
RL   Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=7921239; DOI=10.1099/13500872-140-8-1855;
RA   Longchamp P.F., Mauel C., Karamata D.;
RT   "Lytic enzymes associated with defective prophages of Bacillus subtilis:
RT   sequencing and characterization of the region comprising the N-
RT   acetylmuramoyl-L-alanine amidase gene of prophage PBSX.";
RL   Microbiology 140:1855-1867(1994).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9555893; DOI=10.1128/jb.180.8.2110-2117.1998;
RA   Krogh S., Jorgensen S.T., Devine K.M.;
RT   "Lysis genes of the Bacillus subtilis defective prophage PBSX.";
RL   J. Bacteriol. 180:2110-2117(1998).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
CC   -!- FUNCTION: Involved in cell lysis upon induction of PbsX.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the SPP1 holin family. {ECO:0000305}.
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DR   EMBL; Z36941; CAA85402.1; -; Genomic_DNA.
DR   EMBL; M63943; AAA22889.1; -; Genomic_DNA.
DR   EMBL; L25924; AAA22644.1; -; Genomic_DNA.
DR   EMBL; Z70177; CAA94048.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB13137.1; -; Genomic_DNA.
DR   PIR; F49754; F49754.
DR   RefSeq; NP_389163.1; NC_000964.3.
DR   RefSeq; WP_003232653.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; Q99163; -.
DR   STRING; 224308.BSU12800; -.
DR   TCDB; 1.E.31.1.6; the spp1 holin (spp1 holin) family.
DR   PaxDb; Q99163; -.
DR   PRIDE; Q99163; -.
DR   EnsemblBacteria; CAB13137; CAB13137; BSU_12800.
DR   GeneID; 939732; -.
DR   KEGG; bsu:BSU12800; -.
DR   PATRIC; fig|224308.179.peg.1388; -.
DR   eggNOG; ENOG5033B7V; Bacteria.
DR   OMA; MNTFDKG; -.
DR   PhylomeDB; Q99163; -.
DR   BioCyc; BSUB:BSU12800-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR006479; Holin.
DR   Pfam; PF04688; Holin_SPP1; 1.
DR   TIGRFAMs; TIGR01592; holin_SPP1; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..87
FT                   /note="Holin"
FT                   /id="PRO_0000164431"
FT   TRANSMEM        45..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   87 AA;  9731 MW;  3C7A546298E812A2 CRC64;
     MNTFDKGTVI RTVLLLIALI NQTMLMLGKS PLDIQEEQVN QLADALYSAG SIAFTIGTTL
     AAWFKNNYVT EKGKKQRDLL RDNNLTK