ID   XIRP1_CHICK             Reviewed;        1941 AA.
AC   Q91957;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 3.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Xin actin-binding repeat-containing protein 1;
GN   Name=Xirp1; Synonyms=Xin;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryonic heart;
RX   PubMed=10021346; DOI=10.1242/dev.126.6.1281;
RA   Wang D.-Z., Reiter R.S., Lin J.L.-C., Wang Q., Williams H.S., Krob S.L.,
RA   Schultheiss T.M., Evans S., Lin J.-J.;
RT   "Requirement of a novel gene, Xin, in cardiac morphogenesis.";
RL   Development 126:1281-1294(1999).
RN   [2]
RP   SEQUENCE REVISION.
RA   Wang D.-Z., Lin J.J.-C.;
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protects actin filaments from depolymerization (By
CC       similarity). Involved in cardiac morphogenesis. {ECO:0000250,
CC       ECO:0000269|PubMed:10021346}.
CC   -!- SUBUNIT: Interacts with F-actin, FLNC and VASP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000250}. Note=Colocalizes
CC       with actin stress fibers. {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: First expressed at stage 8 in the paired lateral
CC       plate mesoderm that forms the primordia of the heart. At stages 10 and
CC       11, expressed in the lateral regions of the developing heart tube. At
CC       stage 13, strongly expressed in the right side of the looping heart. At
CC       stage 15, expressed in rostral somites. At stage 20, expressed in
CC       heart, skeletal muscle and tongue. {ECO:0000269|PubMed:10021346}.
CC   -!- DOMAIN: Xin repeats bind F-actin.
CC   -!- SIMILARITY: Belongs to the Xin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00721}.
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DR   EMBL; AF051944; AAC06022.2; -; mRNA.
DR   PIR; T14266; T14266.
DR   AlphaFoldDB; Q91957; -.
DR   STRING; 9031.ENSGALP00000009684; -.
DR   PaxDb; Q91957; -.
DR   VEuPathDB; HostDB:geneid_374266; -.
DR   eggNOG; ENOG502QTAC; Eukaryota.
DR   InParanoid; Q91957; -.
DR   PhylomeDB; Q91957; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR   InterPro; IPR012510; Actin-binding_Xin_repeat.
DR   InterPro; IPR030072; XIRP1/XIRP2.
DR   PANTHER; PTHR22591; PTHR22591; 1.
DR   Pfam; PF08043; Xin; 15.
DR   PROSITE; PS51389; XIN; 27.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cell junction; Developmental protein; Reference proteome;
KW   Repeat.
FT   CHAIN           1..1941
FT                   /note="Xin actin-binding repeat-containing protein 1"
FT                   /id="PRO_0000316985"
FT   REPEAT          108..123
FT                   /note="Xin 1"
FT   REPEAT          143..158
FT                   /note="Xin 2"
FT   REPEAT          176..191
FT                   /note="Xin 3"
FT   REPEAT          215..230
FT                   /note="Xin 4"
FT   REPEAT          255..270
FT                   /note="Xin 5"
FT   REPEAT          293..308
FT                   /note="Xin 6"
FT   REPEAT          331..346
FT                   /note="Xin 7"
FT   REPEAT          368..383
FT                   /note="Xin 8"
FT   REPEAT          402..417
FT                   /note="Xin 9"
FT   REPEAT          439..454
FT                   /note="Xin 10"
FT   REPEAT          475..490
FT                   /note="Xin 11"
FT   REPEAT          510..525
FT                   /note="Xin 12"
FT   REPEAT          548..563
FT                   /note="Xin 13"
FT   REPEAT          586..601
FT                   /note="Xin 14"
FT   REPEAT          624..639
FT                   /note="Xin 15"
FT   REPEAT          658..673
FT                   /note="Xin 16"
FT   REPEAT          697..712
FT                   /note="Xin 17"
FT   REPEAT          736..751
FT                   /note="Xin 18"
FT   REPEAT          769..784
FT                   /note="Xin 19"
FT   REPEAT          805..820
FT                   /note="Xin 20"
FT   REPEAT          842..857
FT                   /note="Xin 21"
FT   REPEAT          880..895
FT                   /note="Xin 22"
FT   REPEAT          917..932
FT                   /note="Xin 23"
FT   REPEAT          951..966
FT                   /note="Xin 24"
FT   REPEAT          982..997
FT                   /note="Xin 25"
FT   REPEAT          1020..1035
FT                   /note="Xin 26"
FT   REPEAT          1055..1070
FT                   /note="Xin 27"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1514..1568
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1715..1856
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1914..1941
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1818..1832
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1833..1850
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1914..1934
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1941 AA;  216271 MW;  996F0523BE8BF495 CRC64;
     MAEPQKSSKV AIKKMEDDLP PPPIPDSIQV IAPASQDPNP LPVPPPKQAF SKFYQQRQVN
     ELKRLYRHMH PELRKNLEEA VTEDLAEMLN TEDPNAQGSV NLDKVLPGEV QSMRWIFENW
     ALDSIGDHQA TKKMMEDEII PGGDVKSTSL RFENQSVNGD YLSTTAKVSE TDLARGDVHT
     ARWLFETQPL DSLNKLYSDE TEMQEAVLKE PVQGGDVKGA KELFEAQSLD AIGRCCSVEE
     KSILQLKSEI QELKGDVKKT IRLFQTEPLC AIRDKTGNIH EIKSVCREEI QSNAVRTARW
     LFETQPLDTI NKDTSKVQII RGISLEEIGR PDVSGARWIF ETQPLDAIRE ITVEEQDFKA
     STDFVTGADV TKQRLLFGTQ ALDSLKGEAS ESVAAKEQVI GGDVKSTLWL FETQPMETLK
     DNVEVGHLKK VELSAEEKGD VKQRKHVFET CPLGSISKAF EEEISAASTE EVVKGDVKSF
     KTLFETLPLD SIKEVDAEPI TKEEEKIPPG NVKANQILFE TTPLYAIKDS FGNFHEVTSV
     SREQVISGDV KKYKWMFETR PLDQFDESTK KVDIIRGITK QEVVAGDVRT AKWLFETQPM
     DVIHHQATQG EEHPSMKREI SQRGDVKTCR WLFETQPMHT LYEKAEKKQE EDVSVPQADV
     KSYTWMFETQ PLDSLKGQEE QYLRVSKAYS QDELQGVDVK TVRHLFETEP LGSSVVSEAD
     QKKTLRYSSR VEIQSGEVSR VKEFFEAKPL DTTTKPTAVI KDDGTIEAGS VHKFTWLFEN
     YPMDTLKDSS EGIQEIPPEK DIKGGDVGGK RFIFETYSLD QIHDKVDETE LHKIQKDTMS
     KANVKSCTML FESQPLYAIQ DKEGGYHEVT SVQKEEIMKG DVKGARWLFE TKPLDQIKKE
     EEVFVIRAVT QEDIKKGDVQ AARWRFETEP LDSFPGGKIS VPRTVDDVQK GDVQSNKQLF
     ESQQVGQKKY VRMVSVSDVQ RGDVRTSTWL FENQPVDSLY GDADRSSSIS TVQREDSQKG
     DVKRCTWLFE TQPMDTLKDP EVTVSTGTQE PIPRADVKST TWLFESTPLD KFSASECSRE
     TELKERTMRE TLETLCTCQA IQHDGILIEA NDTESVKMVK YQLSSPGAPE ILKEEIVRGH
     LQGIMLQLLH RTNVEPQSVL VEEDREGKIK VSSLQLLDQS EAIKGKEDLS GNVAKALQSL
     LSQDASIKKG MVIQETKSES VKMTLYSLLF HSVQQKVVKG DVKSTIGNLM ASSQEQRATV
     TVKREDNEKG NVQLFASCIE KGDLDYLKNL QQESEIQSLI SAQAEQGAAE SAPRALQSTN
     THVLANKEQV EKVMAEAKSG ALEGAKMVFA CESTGKEGAL EREVVHAVGV TGTTVQCLGK
     PQNLPTGMEK EEIMSGGLKV TTKSIQRVAD VSKNTEKEES ISACLKEPKA TMQGIAQAKV
     TAERNEVVGE QQSLVTEQAS QKQSEEKVLG NDLQAAMQSL RLATAEARNI QHHVQSKLQR
     NREEVHMACR QQVASKQETK TLQSTIHQQE SASTMRENTS TAIRTSTTRV QEASRTHTSV
     SQKSIASHKK VSASEEVQGG QLLSQENQVV PSRDVSIKDG LYTATPVKTY INPFVESDYK
     EQSVQEERDV IIRGDVQTAI RALQSAATEQ RLVEKEDIVR GNLKATLQSL EKSNVNVSKG
     DFKAAMIYRN AGQSYSVCKK KSETQVNNNQ TAVVASGSQA DNDFPPPPPV AVMKAEHCPP
     STKATREGAP PLLTSKDEAP GCFSPLQTPL PPPPSLSCKP SDQNSTEKPK IPPKPEITAP
     LRKKPVPPPK PEHLLHEAYS ASTNNSTNRS TKSVPPPVPP KPPGLREISM PKPPPAELQL
     SCTEVCEQSD HRESQDKCCT LESSMDKSIT VHGPERKLPK YTAKTPLQMA EERYKARKGG
     QGKFELDRAK PSKPVKNGEV G