ID   XISC_NOSS1              Reviewed;         498 AA.
AC   Q44217;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Excisase C;
DE   AltName: Full=HupL element site-specific recombinase;
GN   Name=xisC; OrderedLocusNames=alr0677;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7846053; DOI=10.1073/pnas.92.3.791;
RA   Carrasco C.D., Buettner J.A., Golden J.W.;
RT   "Programmed DNA rearrangement of a cyanobacterial hupL gene in
RT   heterocysts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:791-795(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- FUNCTION: Essential for DNA excision. Site specific recombinase
CC       necessary for the excision of the 10.5 kb hupL element during
CC       heterocyst differentiation.
CC   -!- SIMILARITY: Belongs to the XisA/XisC recombinase family. {ECO:0000305}.
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DR   EMBL; U08014; AAC43303.1; -; Genomic_DNA.
DR   EMBL; BA000019; BAB72635.1; -; Genomic_DNA.
DR   PIR; AD1891; AD1891.
DR   RefSeq; WP_010994853.1; NZ_RSCN01000009.1.
DR   AlphaFoldDB; Q44217; -.
DR   STRING; 103690.17130023; -.
DR   EnsemblBacteria; BAB72635; BAB72635; BAB72635.
DR   KEGG; ana:alr0677; -.
DR   eggNOG; COG0582; Bacteria.
DR   OMA; EERYFSE; -.
DR   OrthoDB; 303300at2; -.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0043158; P:heterocyst differentiation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.443.10; -; 1.
DR   InterPro; IPR011010; DNA_brk_join_enz.
DR   InterPro; IPR013762; Integrase-like_cat_sf.
DR   InterPro; IPR002104; Integrase_catalytic.
DR   Pfam; PF00589; Phage_integrase; 1.
DR   SUPFAM; SSF56349; SSF56349; 1.
DR   PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE   3: Inferred from homology;
KW   DNA excision; DNA recombination; Heterocyst; Reference proteome.
FT   CHAIN           1..498
FT                   /note="Excisase C"
FT                   /id="PRO_0000066010"
FT   DOMAIN          263..446
FT                   /note="Tyr recombinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        306
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        336
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        401
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        424
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
FT   ACT_SITE        433
FT                   /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01246"
SQ   SEQUENCE   498 AA;  58195 MW;  1BCEE2DB3D36CC14 CRC64;
     MSGQNQGNCE ETYSTSTHEY ANADSTDWFA DMFADFEPQN TTDGSYRGTM AKIKATELQY
     QAVFEQKLVE ANTNLKRERI RVSIKQTGNS LQLRATLPLK PGDGSLGKTK KQYDLSLGIP
     ANLEGLKTAI EESYELGKLI ARHTFEWNEK YLGIKSREKQ EIKTIGELLD KFEEKYYQTR
     QKTITSQNTF PNYISVIKRN FPLTHLATKE NFEEIINSVQ GNKKNELIAV TSVFIKTFNL
     GFQLDVKRDN VTPAHREIPE DDKIIYSFDL FEKFALNRKN TNISDEIDTW EMWRWVYGML
     ATFGLRPREL FVQPDINWWM SPQNLDHTWK VNKNTKTGYR EVIPFVPEWI ELFDLKNPKP
     LKILEKKVTK IASVQNINWM RRDISRWFRK VGIEFQPYDL RHACAIRAHL QGIPIKAAAD
     NLGHTVDEHT KTYQRWFGIE NRKKAFGEVI SQKSLIELQK NEILALRMEN ERLRLEVEKL
     KFSTTKNPED CEQLYHQG