XI_DEIAC
ID XI_DEIAC Reviewed; 12 AA.
AC Q7LZ26;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 26-FEB-2020, entry version 28.
DE RecName: Full=Coagulation factor X inhibitor;
DE Flags: Fragment;
OS Deinagkistrodon acutus (Hundred-pace snake) (Agkistrodon acutus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Deinagkistrodon.
OX NCBI_TaxID=36307;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Venom;
RX PubMed=8310445; DOI=10.1016/0041-0101(93)90210-a;
RA Cox A.C.;
RT "Coagulation factor X inhibitor from hundred-pace snake (Deinagkistrodon
RT acutus) venom.";
RL Toxicon 31:1445-1457(1993).
CC -!- FUNCTION: Anticoagulant protein. May prevent the complex of factors Xa
CC (F10) and factor Va (F5) from binding to phospholipid surfaces and to
CC prothrombin (F2). Also blocks the activation of factor X (F10) by
CC factor VIIa (F7) and tissue factor (F3) as well.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
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DR PIR; A49261; A49261.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Blood coagulation cascade inhibiting toxin; Direct protein sequencing;
KW Hemostasis impairing toxin; Secreted; Toxin.
FT CHAIN 1..>12
FT /note="Coagulation factor X inhibitor"
FT /id="PRO_0000408519"
FT NON_TER 12
SQ SEQUENCE 12 AA; 1209 MW; 2C732B5F40A5B878 CRC64;
ATPFGGSSYE GH