CAP2_DICDI
ID CAP2_DICDI Reviewed; 287 AA.
AC P34122; B0G113; Q54ZK2;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2003, sequence version 2.
DT 25-MAY-2022, entry version 109.
DE RecName: Full=cAMP-binding protein 2;
DE Short=CABP-2;
DE AltName: Full=CABP1-related protein p31/p34;
GN Name=capB; ORFNames=DDB_G0277501;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS P31 AND P34), SUBCELLULAR LOCATION,
RP SUBUNIT, AND DEVELOPMENTAL STAGE.
RX PubMed=1851802; DOI=10.1099/00221287-137-3-501;
RA Bain G., Grant C.E., Tsang A.;
RT "Isolation and characterization of cDNA clones encoding polypeptides
RT related to a Dictyostelium discoideum cyclic AMP binding protein.";
RL J. Gen. Microbiol. 137:501-508(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16512674; DOI=10.1021/pr050350q;
RA Reinders Y., Schulz I., Graef R., Sickmann A.;
RT "Identification of novel centrosomal proteins in Dictyostelium discoideum
RT by comparative proteomic approaches.";
RL J. Proteome Res. 5:589-598(2006).
CC -!- SUBUNIT: Possibly a heterodimer of p31 and p34. p31/p34 could also
CC associate with CABP1A/CABP1B to form an active complex.
CC {ECO:0000269|PubMed:1851802}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1851802}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=p34;
CC IsoId=P34122-1; Sequence=Displayed;
CC Name=p31;
CC IsoId=P34122-2; Sequence=VSP_000759;
CC -!- DEVELOPMENTAL STAGE: Appears soon after starvation and then remains at
CC constant levels throughout development. {ECO:0000269|PubMed:1851802}.
CC -!- SIMILARITY: Belongs to the CAPAB/TerDEXZ family. {ECO:0000305}.
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DR EMBL; M36174; AAA33169.1; -; mRNA.
DR EMBL; M36175; AAA33170.1; -; mRNA.
DR EMBL; AAFI02000020; EAL68713.1; -; Genomic_DNA.
DR EMBL; AAFI02000020; EDR41094.1; -; Genomic_DNA.
DR PIR; A49752; A49752.
DR PIR; B49752; B49752.
DR RefSeq; XP_001732976.1; XM_001732924.1.
DR RefSeq; XP_642640.1; XM_637548.1.
DR AlphaFoldDB; P34122; -.
DR SMR; P34122; -.
DR IntAct; P34122; 9.
DR STRING; 44689.DDB0185023; -.
DR PaxDb; P34122; -.
DR EnsemblProtists; EAL68713; EAL68713; DDB_G0277501.
DR EnsemblProtists; EDR41094; EDR41094; DDB_G0277501.
DR GeneID; 8621057; -.
DR KEGG; ddi:DDB_G0277501; -.
DR dictyBase; DDB_G0277501; capB.
DR eggNOG; ENOG502SAWS; Eukaryota.
DR HOGENOM; CLU_941427_0_0_1; -.
DR InParanoid; P34122; -.
DR OMA; GNFVFFN; -.
DR PhylomeDB; P34122; -.
DR PRO; PR:P34122; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030552; F:cAMP binding; IEA:UniProtKB-KW.
DR CDD; cd06974; TerD_like; 1.
DR InterPro; IPR003325; TerD.
DR Pfam; PF02342; TerD; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; cAMP; cAMP-binding; Nucleotide-binding; Nucleus;
KW Reference proteome; Repeat.
FT CHAIN 1..287
FT /note="cAMP-binding protein 2"
FT /id="PRO_0000170776"
FT REPEAT 60..68
FT /note="C-1"
FT REPEAT 75..83
FT /note="C-2"
FT REGION 1..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 60..83
FT /note="2 X 9 AA approximate repeats of CABP1 motif C"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..68
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 12..45
FT /note="Missing (in isoform p31)"
FT /evidence="ECO:0000303|PubMed:1851802"
FT /id="VSP_000759"
FT CONFLICT 250
FT /note="G -> V (in Ref. 1; AAA33169)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 287 AA; 30922 MW; 234193FF58509863 CRC64;
MYNPPPPSGS QGNNNYYRQP SSTPGVSNPN PQANQFLPPP PSNTQAPRPG FPPSAPPPSA
PAGQYSMPPP PQQQQQAGQY GMPPPPSGSG IGTGVSLVKD QQISLSKEDP YLRKLTVGLG
WDVNTTPSAP FDLDAVVFML GANGMVRQPA DFIFYNNKQS RDGSIFHHGD NLTGAGDGDD
EVVSVNLQAV SPDVTRLVFA VTIHQPELRR QNFGMVPRAF IRIANQETTR NICRYDLTNE
GGTNTAMIVG EVYRDPQNPQ NWSFIAVGKS FPGGLQFLCQ IFGVNAS
