XKR2_HUMAN
ID XKR2_HUMAN Reviewed; 449 AA.
AC Q6PP77; B2RNN6; B4DKU2; Q5H9J6;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=XK-related protein 2;
DE AltName: Full=Membrane protein XPLAC;
DE AltName: Full=X Kell blood group-related, X-linked;
GN Name=XKRX; Synonyms=XKR2, XPLAC, XRG2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Placenta;
RX PubMed=16431037; DOI=10.1016/j.gene.2005.10.037;
RA Calenda G., Peng J., Redman C.M., Sha Q., Wu X., Lee S.;
RT "Identification of two new members, XPLAC and XTES, of the XK family.";
RL Gene 370:6-16(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Huang C.-H., Chen Y.;
RT "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT and invertebrates.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16431037};
CC Multi-pass membrane protein {ECO:0000269|PubMed:16431037}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PP77-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PP77-2; Sequence=VSP_037520;
CC -!- TISSUE SPECIFICITY: Expressed predominantly in the placenta, in
CC syncytiotrophoblasts. Moderate levels in the adrenal gland, low levels
CC in the trachea and very low levels in the bone marrow.
CC {ECO:0000269|PubMed:16431037}.
CC -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI37011.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAI37012.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAT00456.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAT07088.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY589511; AAT00456.1; ALT_INIT; mRNA.
DR EMBL; AY534239; AAT07088.1; ALT_INIT; mRNA.
DR EMBL; AK296711; BAG59304.1; -; mRNA.
DR EMBL; Z73417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137010; AAI37011.1; ALT_INIT; mRNA.
DR EMBL; BC137011; AAI37012.1; ALT_INIT; mRNA.
DR CCDS; CCDS14476.2; -. [Q6PP77-1]
DR RefSeq; NP_997724.2; NM_212559.2. [Q6PP77-1]
DR RefSeq; XP_005262187.1; XM_005262130.2. [Q6PP77-2]
DR RefSeq; XP_016885006.1; XM_017029517.1. [Q6PP77-2]
DR AlphaFoldDB; Q6PP77; -.
DR BioGRID; 135464; 14.
DR IntAct; Q6PP77; 9.
DR STRING; 9606.ENSP00000362047; -.
DR TCDB; 2.A.112.1.6; the kx blood-group antigen (kxa) family.
DR iPTMnet; Q6PP77; -.
DR PhosphoSitePlus; Q6PP77; -.
DR BioMuta; XKRX; -.
DR DMDM; 77417617; -.
DR PaxDb; Q6PP77; -.
DR PeptideAtlas; Q6PP77; -.
DR PRIDE; Q6PP77; -.
DR ProteomicsDB; 67255; -. [Q6PP77-1]
DR ProteomicsDB; 67256; -. [Q6PP77-2]
DR Antibodypedia; 28561; 85 antibodies from 17 providers.
DR DNASU; 402415; -.
DR Ensembl; ENST00000372956.3; ENSP00000362047.2; ENSG00000182489.9. [Q6PP77-1]
DR GeneID; 402415; -.
DR KEGG; hsa:402415; -.
DR MANE-Select; ENST00000372956.3; ENSP00000362047.2; NM_212559.3; NP_997724.2.
DR UCSC; uc004egn.3; human. [Q6PP77-1]
DR CTD; 402415; -.
DR GeneCards; XKRX; -.
DR HGNC; HGNC:29845; XKRX.
DR HPA; ENSG00000182489; Tissue enhanced (brain, skin).
DR MIM; 300684; gene.
DR neXtProt; NX_Q6PP77; -.
DR OpenTargets; ENSG00000182489; -.
DR PharmGKB; PA134962569; -.
DR VEuPathDB; HostDB:ENSG00000182489; -.
DR eggNOG; ENOG502QSH6; Eukaryota.
DR GeneTree; ENSGT00390000003231; -.
DR HOGENOM; CLU_037429_1_0_1; -.
DR InParanoid; Q6PP77; -.
DR OMA; SETYWMA; -.
DR OrthoDB; 768086at2759; -.
DR PhylomeDB; Q6PP77; -.
DR TreeFam; TF331465; -.
DR PathwayCommons; Q6PP77; -.
DR SignaLink; Q6PP77; -.
DR BioGRID-ORCS; 402415; 8 hits in 689 CRISPR screens.
DR ChiTaRS; XKRX; human.
DR GenomeRNAi; 402415; -.
DR Pharos; Q6PP77; Tdark.
DR PRO; PR:Q6PP77; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q6PP77; protein.
DR Bgee; ENSG00000182489; Expressed in skin of limb and 73 other tissues.
DR ExpressionAtlas; Q6PP77; baseline and differential.
DR Genevisible; Q6PP77; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018629; XK-rel.
DR Pfam; PF09815; XK-related; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..449
FT /note="XK-related protein 2"
FT /id="PRO_0000190772"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 357..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..204
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_037520"
FT CONFLICT 340
FT /note="V -> A (in Ref. 3; BAG59304)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 449 AA; 52052 MW; 29DB15BC41796730 CRC64;
MDRVYEIPEE PNVDPVSSLE EDVIRGANPR FTFPFSILFS TFLYCGEAAS ALYMVRIYRK
NSETYWMTYT FSFFMFSSIM VQLTLIFVHR DLAKDKPLSL FMHLILLGPV IRCLEAMIKY
LTLWKKEEQE EPYVSLTRKK MLIDGEEVLI EWEVGHSIRT LAMHRNAYKR MSQIQAFLGS
VPQLTYQLYV SLISAEVPLG RVVLMVFSLV SVTYGATLCN MLAIQIKYDD YKIRLGPLEV
LCITIWRTLE ITSRLLILVL FSATLKLKAV PFLVLNFLII LFEPWIKFWR SGAQMPNNIE
KNFSRVGTLV VLISVTILYA GINFSCWSAL QLRLADRDLV DKGQNWGHMG LHYSVRLVEN
VIMVLVFKFF GVKVLLNYCH SLIALQLIIA YLISIGFMLL FFQYLHPLRS LFTHNVVDYL
HCVCCHQHPR TRVENSEPPF ETEARQSVV
