ID   XKR2_MOUSE              Reviewed;         449 AA.
AC   Q5GH68; A2AEK6;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=XK-related protein 2;
DE   AltName: Full=X Kell blood group-related, X-linked;
GN   Name=Xkrx; Synonyms=Xkr2, Xrg2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR   EMBL; AY534249; AAT07098.1; -; mRNA.
DR   EMBL; AL671915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC150896; AAI50897.1; -; mRNA.
DR   EMBL; BC150897; AAI50898.1; -; mRNA.
DR   CCDS; CCDS30391.1; -.
DR   RefSeq; NP_899142.2; NM_183319.2.
DR   AlphaFoldDB; Q5GH68; -.
DR   BioGRID; 237108; 2.
DR   STRING; 10090.ENSMUSP00000033611; -.
DR   iPTMnet; Q5GH68; -.
DR   PhosphoSitePlus; Q5GH68; -.
DR   EPD; Q5GH68; -.
DR   PaxDb; Q5GH68; -.
DR   PRIDE; Q5GH68; -.
DR   ProteomicsDB; 300001; -.
DR   Antibodypedia; 28561; 85 antibodies from 17 providers.
DR   DNASU; 331524; -.
DR   Ensembl; ENSMUST00000033611; ENSMUSP00000033611; ENSMUSG00000031258.
DR   GeneID; 331524; -.
DR   KEGG; mmu:331524; -.
DR   UCSC; uc009ufo.1; mouse.
DR   CTD; 402415; -.
DR   MGI; MGI:3584011; Xkrx.
DR   VEuPathDB; HostDB:ENSMUSG00000031258; -.
DR   eggNOG; ENOG502QSH6; Eukaryota.
DR   GeneTree; ENSGT00390000003231; -.
DR   HOGENOM; CLU_037429_1_0_1; -.
DR   InParanoid; Q5GH68; -.
DR   OMA; SETYWMA; -.
DR   OrthoDB; 768086at2759; -.
DR   PhylomeDB; Q5GH68; -.
DR   TreeFam; TF331465; -.
DR   BioGRID-ORCS; 331524; 1 hit in 74 CRISPR screens.
DR   ChiTaRS; Xkrx; mouse.
DR   PRO; PR:Q5GH68; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q5GH68; protein.
DR   Bgee; ENSMUSG00000031258; Expressed in lip and 52 other tissues.
DR   Genevisible; Q5GH68; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   InterPro; IPR018629; XK-rel.
DR   Pfam; PF09815; XK-related; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..449
FT                   /note="XK-related protein 2"
FT                   /id="PRO_0000190773"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        269..289
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        357..377
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        382..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   449 AA;  51778 MW;  0FD7BFCDE2A87EF7 CRC64;
     MDRVYEIPEE PNVVPISSLE EDVIRGPNPR FTFPFSILFS TFLYCGEAAS ALYMVRIYRK
     NNETFWMTYT FSFFMFSSIM VQLTLIFVHR DLAKDRPLSL FMHLILLGPV IRCLEAMIKY
     LTLWKKEGQE EPYVSLTRKK MLIAGQEVLI EWEVGHSIRT LAMHRNAYKR MSQIQAFLGS
     VPQLTYQLYV SLISAEVPLG RAVLMAFSLI SVTYGATLCN MLAIQIKYDD YKIRLGPLEV
     LCITVWRTLE ITSRLVILVL FSATLKLKAV PFLVLNFLII LFEPWVKFWR SGAQMPNNIE
     KNFSRVGTLV VLISVTILYA GINFSCWSAM QLKLADRDLV DKGQNWGHMG LHYSVRLVEN
     VIMVLVFKYF GVKVLLNYCH SLIAVQLIIA YLISIGVMLL FFQYLHPLRS LFTNNVVDYL
     HCICCRRPRP ERVENSETSC EADTTQSIV