ID   XKR2_RAT                Reviewed;         448 AA.
AC   Q5GH60;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=XK-related protein 2;
DE   AltName: Full=X Kell blood group-related, X-linked;
GN   Name=Xkrx; Synonyms=Xkr2, Xrg2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR   EMBL; AY534257; AAT07106.1; -; mRNA.
DR   RefSeq; NP_001012230.1; NM_001012230.1.
DR   AlphaFoldDB; Q5GH60; -.
DR   SMR; Q5GH60; -.
DR   STRING; 10116.ENSRNOP00000051148; -.
DR   PaxDb; Q5GH60; -.
DR   Ensembl; ENSRNOT00000114392; ENSRNOP00000090437; ENSRNOG00000067363.
DR   GeneID; 497101; -.
DR   KEGG; rno:497101; -.
DR   UCSC; RGD:1359223; rat.
DR   CTD; 402415; -.
DR   RGD; 1359223; Xkrx.
DR   eggNOG; ENOG502QSH6; Eukaryota.
DR   GeneTree; ENSGT00390000003231; -.
DR   HOGENOM; CLU_037429_1_0_1; -.
DR   InParanoid; Q5GH60; -.
DR   OMA; SETYWMA; -.
DR   OrthoDB; 768086at2759; -.
DR   PhylomeDB; Q5GH60; -.
DR   TreeFam; TF331465; -.
DR   PRO; PR:Q5GH60; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000054136; Expressed in esophagus and 6 other tissues.
DR   Genevisible; Q5GH60; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR   InterPro; IPR018629; XK-rel.
DR   Pfam; PF09815; XK-related; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..448
FT                   /note="XK-related protein 2"
FT                   /id="PRO_0000190774"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        305..325
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        381..401
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   448 AA;  52048 MW;  38F93DE2B9631ACA CRC64;
     MDRVYEIPEE PNVVPIASLE DVIRGPNPRF TFPFSILFST FLYCGEAASA LYMVRIYRKN
     NETFWMTYTF SFFMFSSIMV QLTLIFVHRD LAKDRPLSLF MHLILLGPVI RCLEAMIKYL
     TLWKKEGQEE PYVSLTRKKM LIDGQEVLIE WEVGHSIRTL AMHRNAYKRM SQIQAFLGSV
     PQLTYQLYVT LISAEVPLGR AVLMFFSLIS VTYGATLCNM LAIQIKYDDY KIRLGPVEVL
     CITIWRTLEI TSRLMILVLF SATLKLKAVP FLVLNFLIIL FEPWVKFWRS GAQMPNNIEK
     NFSRVGTLVV LISVTILYAG INFSCWSAMQ LKLADRDLVD KGQNWGHMGL HYSVRLVENV
     IMVLVFKYFG VKVLLNYSHS LMAIQLIIAY LISIGFMLLF FQYLHPLRSL FTHNVVDYLH
     CICCRRHHRE RVENSETSCE PDTRQSIV