XKR3_HUMAN
ID XKR3_HUMAN Reviewed; 459 AA.
AC Q5GH77; B2RPN1; Q52PG8; Q8N7E1;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=XK-related protein 3;
DE AltName: Full=X Kell blood group-related 3;
DE AltName: Full=XTES;
GN Name=XKR3; Synonyms=XRG3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Huang C.-H., Chen Y.;
RT "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT and invertebrates.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP VARIANTS LEU-255 AND ASN-442.
RC TISSUE=Testis;
RX PubMed=16431037; DOI=10.1016/j.gene.2005.10.037;
RA Calenda G., Peng J., Redman C.M., Sha Q., Wu X., Lee S.;
RT "Identification of two new members, XPLAC and XTES, of the XK family.";
RL Gene 370:6-16(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS LEU-232; LEU-255 AND
RP ASN-442.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16431037};
CC Multi-pass membrane protein {ECO:0000269|PubMed:16431037}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly, if not exclusively, in
CC testis. {ECO:0000269|PubMed:16431037}.
CC -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR EMBL; AY534240; AAT07089.1; -; mRNA.
DR EMBL; AY989815; AAX86010.1; -; mRNA.
DR EMBL; AK098608; BAC05352.1; -; mRNA.
DR EMBL; BC137521; AAI37522.1; -; mRNA.
DR EMBL; BC137522; AAI37523.1; -; mRNA.
DR CCDS; CCDS42975.1; -.
DR RefSeq; NP_001305180.1; NM_001318251.1.
DR RefSeq; NP_787074.2; NM_175878.4.
DR RefSeq; XP_016884089.1; XM_017028600.1.
DR AlphaFoldDB; Q5GH77; -.
DR BioGRID; 127266; 7.
DR STRING; 9606.ENSP00000331704; -.
DR TCDB; 2.A.112.1.7; the kx blood-group antigen (kxa) family.
DR iPTMnet; Q5GH77; -.
DR PhosphoSitePlus; Q5GH77; -.
DR BioMuta; XKR3; -.
DR DMDM; 74707819; -.
DR jPOST; Q5GH77; -.
DR MassIVE; Q5GH77; -.
DR PaxDb; Q5GH77; -.
DR PeptideAtlas; Q5GH77; -.
DR PRIDE; Q5GH77; -.
DR Antibodypedia; 22625; 76 antibodies from 17 providers.
DR DNASU; 150165; -.
DR Ensembl; ENST00000331428.5; ENSP00000331704.5; ENSG00000172967.8.
DR Ensembl; ENST00000684488.1; ENSP00000507478.1; ENSG00000172967.8.
DR GeneID; 150165; -.
DR KEGG; hsa:150165; -.
DR MANE-Select; ENST00000684488.1; ENSP00000507478.1; NM_001386955.1; NP_001373884.1.
DR UCSC; uc002zlv.4; human.
DR CTD; 150165; -.
DR DisGeNET; 150165; -.
DR GeneCards; XKR3; -.
DR HGNC; HGNC:28778; XKR3.
DR HPA; ENSG00000172967; Tissue enriched (testis).
DR MIM; 611674; gene.
DR neXtProt; NX_Q5GH77; -.
DR OpenTargets; ENSG00000172967; -.
DR PharmGKB; PA142670562; -.
DR VEuPathDB; HostDB:ENSG00000172967; -.
DR eggNOG; ENOG502QSH6; Eukaryota.
DR GeneTree; ENSGT00390000003231; -.
DR HOGENOM; CLU_037429_1_1_1; -.
DR InParanoid; Q5GH77; -.
DR OMA; NFMQQKA; -.
DR OrthoDB; 768086at2759; -.
DR PhylomeDB; Q5GH77; -.
DR TreeFam; TF331465; -.
DR PathwayCommons; Q5GH77; -.
DR BioGRID-ORCS; 150165; 19 hits in 1076 CRISPR screens.
DR ChiTaRS; XKR3; human.
DR GenomeRNAi; 150165; -.
DR Pharos; Q5GH77; Tbio.
DR PRO; PR:Q5GH77; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q5GH77; protein.
DR Bgee; ENSG00000172967; Expressed in testis and 16 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR018629; XK-rel.
DR Pfam; PF09815; XK-related; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..459
FT /note="XK-related protein 3"
FT /id="PRO_0000190776"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 264..284
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 345..365
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 143
FT /note="T -> M (in dbSNP:rs5748648)"
FT /id="VAR_053740"
FT VARIANT 232
FT /note="P -> L (in dbSNP:rs9605146)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_053741"
FT VARIANT 255
FT /note="F -> L (in dbSNP:rs5748623)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:16431037"
FT /id="VAR_053742"
FT VARIANT 442
FT /note="H -> N (in dbSNP:rs5748622)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:16431037"
FT /id="VAR_053743"
SQ SEQUENCE 459 AA; 53448 MW; 291FDD2A952F6BD8 CRC64;
METVFEEMDE ESTGGVSSSK EEIVLGQRLH LSFPFSIIFS TVLYCGEVAF GLYMFEIYRK
ANDTFWMSFT ISFIIVGAIL DQIILMFFNK DLRRNKAALL FWHILLLGPI VRCLHTIRNY
HKWLKNLKQE KEETQVSITK RNTMLEREIA FSIRDNFMQQ KAFKYMSVIQ AFLGSVPQLI
LQMYISLTIR EWPLNRALLM TFSLLSVTYG AIRCNILAIQ ISNDDTTIKL PPIEFFCVVM
WRFLEVISRV VTLAFFIASL KLKSLPVLLI IYFVSLLAPW LEFWKSGAHL PGNKENNSNM
VGTVLMLFLI TLLYAAINFS CWSAVKLQLS DDKIIDGRQR WGHRILHYSF QFLENVIMIL
VFRFFGGKTL LNCCDSLIAV QLIISYLLAT GFMLLFYQYL YPWQSGKVLP GRTENQPEAP
YYYVNIEKTE KNKNKQLRNY CHSCNRVGYF SIRKSMTCS
