ID   XKR4_TETNG              Reviewed;         498 AA.
AC   Q49LS9; Q4RJ02;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=XK-related protein 4 {ECO:0000305};
GN   Name=xkr4 {ECO:0000250|UniProtKB:Q5GH76};
GN   Synonyms=xrg4 {ECO:0000303|Ref.1};
GN   ORFNames=GSTENG00033649001 {ECO:0000303|PubMed:15496914};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- FUNCTION: Phospholipid scramblase that promotes phosphatidylserine
CC       exposure on apoptotic cell surface. Phosphatidylserine is a specific
CC       marker only present at the surface of apoptotic cells and acts as a
CC       specific signal for engulfment. {ECO:0000250|UniProtKB:Q5GH67}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-
CC         sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663,
CC         ChEBI:CHEBI:57262; Evidence={ECO:0000250|UniProtKB:Q5GH67};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5GH67};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG11630.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY702900; AAU94453.1; -; mRNA.
DR   EMBL; CAAE01015040; CAG11630.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q49LS9; -.
DR   KEGG; tng:GSTEN00033649G001; -.
DR   InParanoid; Q49LS9; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018629; XK-rel.
DR   Pfam; PF09815; XK-related; 2.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..498
FT                   /note="XK-related protein 4"
FT                   /id="PRO_0000190781"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        302..322
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        332..352
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          24..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          166..203
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..200
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   498 AA;  55491 MW;  BC162EA216E2B336 CRC64;
     MAAKSDGVLK MKKSDVAFTP LQNSEHSGSV QGLHPGAQPD SAGAGDADFA NGESRCCGGG
     GSHSTCLRLS REQQKYTVWD CLWIVAAVAV YVADVGSDVW LSVDYYLEED YWWFGLTLFF
     VVLGSFSVQL FSFRWFVHDF STEDSAEAAA DGSHMDGNKL LSGSASHGDV TAQHHPATPQ
     RQASTASRNT TTNSTASTGL GPRGPKRPAY YTFCVWGSQS VIHILQLGQI WRYIHTIYLG
     VQSRQSAETE RWRYYWRMVY EFADVSMLHL LATFLESAPQ LVLQLCIIIQ THKLLAVQGC
     RLFIYYLLIL AENAALSALW YLYRSPLATD AFAVPALCVI FSSFLTGVVF MLMYYAFFHP
     NGPRFGRSMS GHGLNLDPTA QFSTLPSEVA TNSLRSNRGA TATLERDAGK YSERDGCMPV
     FQVRPTVPST PSSRAPRLEE TVIKIDLCRN RYPAWERHVL DRSIRKAILA VDCSLTPPRL
     QYKDDALVQE RLEYETTL