XKR5_HUMAN
ID XKR5_HUMAN Reviewed; 686 AA.
AC Q6UX68; A0A087X143; A0A096LPC1; Q5GH74;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=XK-related protein 5 {ECO:0000305};
GN Name=XKR5 {ECO:0000312|HGNC:HGNC:20782}; Synonyms=XRG5 {ECO:0000303|Ref.1};
GN ORFNames=UNQ2754/PRO6493 {ECO:0000303|PubMed:12975309};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA Huang C.-H., Chen Y.;
RT "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT and invertebrates.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5GH66};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=5a {ECO:0000303|Ref.1};
CC IsoId=Q6UX68-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UX68-3; Sequence=VSP_059371, VSP_059372;
CC -!- MISCELLANEOUS: [Isoform 2]: May be produced at very low levels due to a
CC premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAT07092.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR EMBL; AY534242; AAT07091.1; -; mRNA.
DR EMBL; AY534243; AAT07092.1; ALT_SEQ; mRNA.
DR EMBL; AY358489; AAQ88853.1; -; mRNA.
DR EMBL; AF233439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KF495715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471153; EAW80480.1; -; Genomic_DNA.
DR CCDS; CCDS47763.2; -. [Q6UX68-1]
DR RefSeq; NP_001276902.1; NM_001289973.1.
DR RefSeq; NP_997294.3; NM_207411.4. [Q6UX68-1]
DR AlphaFoldDB; Q6UX68; -.
DR SMR; Q6UX68; -.
DR BioGRID; 133187; 1.
DR IntAct; Q6UX68; 1.
DR STRING; 9606.ENSP00000483879; -.
DR TCDB; 2.A.112.1.14; the kx blood-group antigen (kxa) family.
DR iPTMnet; Q6UX68; -.
DR PhosphoSitePlus; Q6UX68; -.
DR BioMuta; XKR5; -.
DR DMDM; 74738183; -.
DR MassIVE; Q6UX68; -.
DR PeptideAtlas; Q6UX68; -.
DR PRIDE; Q6UX68; -.
DR ProteomicsDB; 67569; -. [Q6UX68-1]
DR Antibodypedia; 74670; 8 antibodies from 4 providers.
DR DNASU; 389610; -.
DR Ensembl; ENST00000618742.3; ENSP00000483879.1; ENSG00000275591.5. [Q6UX68-1]
DR Ensembl; ENST00000618990.4; ENSP00000485506.1; ENSG00000275591.5. [Q6UX68-3]
DR GeneID; 389610; -.
DR KEGG; hsa:389610; -.
DR MANE-Select; ENST00000618742.3; ENSP00000483879.1; NM_207411.5; NP_997294.3.
DR UCSC; uc033baq.2; human.
DR CTD; 389610; -.
DR GeneCards; XKR5; -.
DR HGNC; HGNC:20782; XKR5.
DR HPA; ENSG00000275591; Not detected.
DR neXtProt; NX_Q6UX68; -.
DR OpenTargets; ENSG00000275591; -.
DR PharmGKB; PA142670564; -.
DR VEuPathDB; HostDB:ENSG00000275591; -.
DR eggNOG; KOG4790; Eukaryota.
DR GeneTree; ENSGT00990000203579; -.
DR InParanoid; Q6UX68; -.
DR OMA; CSLVMLH; -.
DR OrthoDB; 1230316at2759; -.
DR PhylomeDB; Q6UX68; -.
DR PathwayCommons; Q6UX68; -.
DR SignaLink; Q6UX68; -.
DR BioGRID-ORCS; 389610; 0 hits in 139 CRISPR screens.
DR GenomeRNAi; 389610; -.
DR Pharos; Q6UX68; Tdark.
DR PRO; PR:Q6UX68; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q6UX68; protein.
DR Bgee; ENSG00000275591; Expressed in stromal cell of endometrium and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:1902742; P:apoptotic process involved in development; IBA:GO_Central.
DR GO; GO:0043652; P:engulfment of apoptotic cell; IBA:GO_Central.
DR GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IBA:GO_Central.
DR InterPro; IPR018629; XK-rel.
DR Pfam; PF09815; XK-related; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..686
FT /note="XK-related protein 5"
FT /id="PRO_0000190782"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 339..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 490..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 490..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 82..86
FT /note="HWDAA -> PQIHL (in isoform 2)"
FT /id="VSP_059371"
FT VAR_SEQ 87..686
FT /note="Missing (in isoform 2)"
FT /id="VSP_059372"
FT CONFLICT 69
FT /note="M -> V (in Ref. 1; AAT07091 and 2; AAQ88853)"
SQ SEQUENCE 686 AA; 75014 MW; DD0B46DA37F27F57 CRC64;
MHARLLGLSA LLQAAEQSAR LYTVAYYFTT GRLLWGWLAL AVLLPGFLVQ ALSYLWFRAD
GHPGHCSLMM LHLLQLGVWK RHWDAALTSL QKELEAPHRG WLQLQEADLS ALRLLEALLQ
TGPHLLLQTY VFLASDFTDI VPGVSTLFSW SSLSWALVSY TRFMGFMKPG HLAMPWAALF
CQQLWRMGML GTRVLSLVLF YKAYHFWVFV VAGAHWLVMT FWLVAQQSDI IDSTCHWRLF
NLLVGAVYIL CYLSFWDSPS RNRMVTFYMV MLLENIILLL LATDFLQGAS WTSLQTIAGV
LSGFLIGSVS LVIYYSLLHP KSTDIWQGCL RKSCGIAGGD KTERRDSPRA TDLAGKRTES
SGSCQGASYE PTILGKPPTP EQVPPEAGLG TQVAVEDSFL SHHHWLWVKL ALKTGNVSKI
NAAFGDNSPA YCPPAWGLSQ QDYLQRKALS AQQELPSSSR DPSTLENSSA FEGVPKAEAD
PLETSSYVSF ASDQQDEAPT QNPAATQGEG TPKEGADAVS GTQGKGTGGQ QRGGEGQQSS
TLYFSATAEV ATSSQQEGSP ATLQTAHSGR RLGKSSPAQP ASPHPVGLAP FPDTMADISP
ILGTGPCRGF CPSAGFPGRT LSISELEEPL EPKRELSHHA AVGVWVSLPQ LRTAHEPCLT
STPKSESIQT DCSCREQMKQ EPSFFI
