ID   XKR5_MOUSE              Reviewed;         676 AA.
AC   Q5GH66;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=XK-related protein 5 {ECO:0000305};
GN   Name=Xkr5 {ECO:0000303|PubMed:25231987, ECO:0000312|MGI:MGI:2442327};
GN   Synonyms=Xrg5 {ECO:0000303|Ref.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=25231987; DOI=10.1074/jbc.m114.583419;
RA   Suzuki J., Imanishi E., Nagata S.;
RT   "Exposure of phosphatidylserine by Xk-related protein family members during
RT   apoptosis.";
RL   J. Biol. Chem. 289:30257-30267(2014).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25231987};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR   EMBL; AY534251; AAT07100.1; -; mRNA.
DR   CCDS; CCDS52495.1; -.
DR   RefSeq; NP_001106821.1; NM_001113350.2.
DR   RefSeq; NP_001273398.1; NM_001286469.1.
DR   RefSeq; NP_795925.1; NM_176951.5.
DR   AlphaFoldDB; Q5GH66; -.
DR   SMR; Q5GH66; -.
DR   STRING; 10090.ENSMUSP00000093089; -.
DR   iPTMnet; Q5GH66; -.
DR   PhosphoSitePlus; Q5GH66; -.
DR   PaxDb; Q5GH66; -.
DR   PRIDE; Q5GH66; -.
DR   ProteomicsDB; 299708; -.
DR   Antibodypedia; 74670; 8 antibodies from 4 providers.
DR   Ensembl; ENSMUST00000095438; ENSMUSP00000093089; ENSMUSG00000039814.
DR   GeneID; 319581; -.
DR   KEGG; mmu:319581; -.
DR   UCSC; uc009kzw.3; mouse.
DR   CTD; 389610; -.
DR   MGI; MGI:2442327; Xkr5.
DR   VEuPathDB; HostDB:ENSMUSG00000039814; -.
DR   eggNOG; KOG4790; Eukaryota.
DR   GeneTree; ENSGT00990000203579; -.
DR   HOGENOM; CLU_025738_1_0_1; -.
DR   InParanoid; Q5GH66; -.
DR   OMA; CSLVMLH; -.
DR   OrthoDB; 1230316at2759; -.
DR   PhylomeDB; Q5GH66; -.
DR   TreeFam; TF316454; -.
DR   BioGRID-ORCS; 319581; 2 hits in 70 CRISPR screens.
DR   PRO; PR:Q5GH66; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q5GH66; protein.
DR   Bgee; ENSMUSG00000039814; Expressed in epiblast (generic) and 54 other tissues.
DR   ExpressionAtlas; Q5GH66; baseline and differential.
DR   Genevisible; Q5GH66; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:1902742; P:apoptotic process involved in development; IBA:GO_Central.
DR   GO; GO:0043652; P:engulfment of apoptotic cell; IBA:GO_Central.
DR   GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IBA:GO_Central.
DR   InterPro; IPR018629; XK-rel.
DR   Pfam; PF09815; XK-related; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..676
FT                   /note="XK-related protein 5"
FT                   /id="PRO_0000190783"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          336..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          372..391
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          495..538
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          598..661
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        375..391
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   676 AA;  74634 MW;  933CE19A521D7479 CRC64;
     MHAGLLGLSA LLQAAEQSAR LCSIVFYFAT GRLLWGWLAL SVLLPGFLVQ ALSFLWFRAD
     GHQGQWWLAV LHLLQLGVWK RHWDSVATAL WKGKEAPSWG QLHLQEADLS ALRLLEALLQ
     TGPHLLLQAY VFLASDFTDI VPGISALLSW SSLSWALVSY NRFLGIMKPG HHTMLWAALL
     CQQLWRMGML GARVLSLVLF CRVYRVWVLV VGGAHWLVMT FWLVAQQSDI VESTCHWRLF
     NLLVGAVFIL CYINFWDSPS RSRVASFYLV MLLENSILLL LATDFLQGVP GTSLWTVVGV
     LSGFLIGCAS LVIYYSLLHP KSSDIQQSFM RKCCGPIEDN KPESEPPPRA VDPTGEMPDS
     SSWCQEESYE LTSLDKAPSP EQNTAEVGLG EQRSGESSFF SHHHWLLLKL ALKTGSVSRI
     NAALGGDSPG CSCPPLLGSS QHCDLQRKPL FSHQDLPSSP CDPLTLEKGS EYVGAPKAEM
     ESLETSSYLS FASELEDNAT TQKPPATQED SPKLAGSKAD LAAQGKETEG PLQGKEGQES
     TTLYFSAAMD RTTSHQRGSP VVLRISHSET LVESRPGQPA LPQAVTKPFP VTVANISPIP
     GRNFRPSAEL PGRAPDSSEC EEWKDAARDP SMQSSLPKMR LKAAEEPCFT STPKSESIQR
     DYSCRDRVRQ EMSFFI