ID   XKR5_PANTR              Reviewed;         686 AA.
AC   Q49LS3;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=XK-related protein 5 {ECO:0000305};
GN   Name=XKR5 {ECO:0000250|UniProtKB:Q5GH66};
GN   Synonyms=XRG5 {ECO:0000303|Ref.1};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5GH66};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR   EMBL; AY702908; AAV83781.1; -; mRNA.
DR   RefSeq; NP_001028207.1; NM_001033035.1.
DR   AlphaFoldDB; Q49LS3; -.
DR   SMR; Q49LS3; -.
DR   STRING; 9598.ENSPTRP00000054982; -.
DR   PaxDb; Q49LS3; -.
DR   Ensembl; ENSPTRT00000062425; ENSPTRP00000054982; ENSPTRG00000019950.
DR   GeneID; 463970; -.
DR   KEGG; ptr:463970; -.
DR   CTD; 389610; -.
DR   VGNC; VGNC:2450; XKR5.
DR   eggNOG; KOG4790; Eukaryota.
DR   GeneTree; ENSGT00990000203579; -.
DR   HOGENOM; CLU_025738_1_0_1; -.
DR   InParanoid; Q49LS3; -.
DR   OMA; CSLVMLH; -.
DR   OrthoDB; 1230316at2759; -.
DR   TreeFam; TF316454; -.
DR   Proteomes; UP000002277; Chromosome 8.
DR   Bgee; ENSPTRG00000019950; Expressed in fibroblast.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:1902742; P:apoptotic process involved in development; IBA:GO_Central.
DR   GO; GO:0043652; P:engulfment of apoptotic cell; IBA:GO_Central.
DR   GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IBA:GO_Central.
DR   InterPro; IPR018629; XK-rel.
DR   Pfam; PF09815; XK-related; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..686
FT                   /note="XK-related protein 5"
FT                   /id="PRO_0000190784"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          340..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          490..589
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..508
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        523..572
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   686 AA;  74869 MW;  9553118305DFD27F CRC64;
     MHAGLLGLSA LLQAAEQSAR LYTVAYYFTT GRLLWGWLAL AVLLPGFLVQ ALSYLWFRAD
     GHPGHCSLVM LHLLQLGVWK RHWDAALTAL QKEPEAPHRG WLQLQEADLS ALRLLEALLQ
     TGPHLLLQTY VFLASDFTDI VPGVSTLFSW SSLSWALVSY TRFMGFMKPG HLAMPWAALF
     CQQLWRMGML GTRVMSLVLF YKAYHFWVFV VAGAHWLVMT FWLVAQQSDI IDSTCHWRLF
     NLLVGAVYIL CYLSFWDSPS RNRMVTFYMV MLLENTILLL LATDFLQGAS WTSLQTIAGV
     LSGFLIGSVS LVIYYSLLHP KSTDIWQGCL RKSCGIAGGD KTERRASPRA TDLAGKRTES
     SGSCQGASYE LTILGKPPTP EQVPPEAGLG TQVAVEDSFL SHHHWLWVKL ALKTGNMSKI
     NAAFGDDNPV YCPPAWGLSQ QDDLQRKALS AQRELPSSSR HPSTLENSSA FEGVSKAEAD
     PLETSSYVSF ASDQQDEAPT QNPAATQGEG TPKEGADAVS GTQGKGTGGQ QRGGEGQQSS
     TLYFSATAEV ATSSQQEGSP ATLQTAHSGR RLGKSSPAQP ASPHPVGLAP FPATMADISP
     ILGTGPCRGF CPSAGFPGRT LSISELEEPL EPTRELSHHA AVGVWMSLPQ LRTAHEPCLT
     STPKSESIQT DCSCREQMKQ EPSFFI