XKR6_HUMAN
ID XKR6_HUMAN Reviewed; 641 AA.
AC Q5GH73; Q8TBA0;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=XK-related protein 6 {ECO:0000305};
GN Name=XKR6 {ECO:0000312|HGNC:HGNC:27806};
GN Synonyms=C8orf21 {ECO:0000312|HGNC:HGNC:27806},
GN C8orf5 {ECO:0000312|HGNC:HGNC:27806}, C8orf7 {ECO:0000312|HGNC:HGNC:27806},
GN XRG6 {ECO:0000303|Ref.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Huang C.-H., Chen Y.;
RT "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT and invertebrates.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lymph;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:E9Q6C8};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5GH73-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5GH73-2; Sequence=VSP_014663;
CC -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR EMBL; AY534244; AAT07093.1; -; mRNA.
DR EMBL; BC024146; AAH24146.1; -; mRNA.
DR CCDS; CCDS5978.2; -. [Q5GH73-1]
DR RefSeq; NP_775954.2; NM_173683.3. [Q5GH73-1]
DR AlphaFoldDB; Q5GH73; -.
DR SMR; Q5GH73; -.
DR BioGRID; 130280; 7.
DR IntAct; Q5GH73; 1.
DR STRING; 9606.ENSP00000416707; -.
DR iPTMnet; Q5GH73; -.
DR PhosphoSitePlus; Q5GH73; -.
DR BioMuta; XKR6; -.
DR DMDM; 71153416; -.
DR MassIVE; Q5GH73; -.
DR PaxDb; Q5GH73; -.
DR PeptideAtlas; Q5GH73; -.
DR PRIDE; Q5GH73; -.
DR ProteomicsDB; 62832; -. [Q5GH73-1]
DR ProteomicsDB; 62833; -. [Q5GH73-2]
DR Antibodypedia; 8456; 40 antibodies from 14 providers.
DR DNASU; 286046; -.
DR Ensembl; ENST00000416569.3; ENSP00000416707.2; ENSG00000171044.11. [Q5GH73-1]
DR GeneID; 286046; -.
DR KEGG; hsa:286046; -.
DR MANE-Select; ENST00000416569.3; ENSP00000416707.2; NM_173683.4; NP_775954.2.
DR UCSC; uc003wtk.3; human. [Q5GH73-1]
DR CTD; 286046; -.
DR DisGeNET; 286046; -.
DR GeneCards; XKR6; -.
DR HGNC; HGNC:27806; XKR6.
DR HPA; ENSG00000171044; Tissue enriched (brain).
DR neXtProt; NX_Q5GH73; -.
DR OpenTargets; ENSG00000171044; -.
DR PharmGKB; PA134922549; -.
DR VEuPathDB; HostDB:ENSG00000171044; -.
DR eggNOG; KOG4790; Eukaryota.
DR GeneTree; ENSGT00990000203579; -.
DR HOGENOM; CLU_028534_1_0_1; -.
DR InParanoid; Q5GH73; -.
DR OMA; VWVWQTI; -.
DR OrthoDB; 1230316at2759; -.
DR PhylomeDB; Q5GH73; -.
DR TreeFam; TF316454; -.
DR PathwayCommons; Q5GH73; -.
DR SignaLink; Q5GH73; -.
DR BioGRID-ORCS; 286046; 14 hits in 1066 CRISPR screens.
DR ChiTaRS; XKR6; human.
DR GenomeRNAi; 286046; -.
DR Pharos; Q5GH73; Tdark.
DR PRO; PR:Q5GH73; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q5GH73; protein.
DR Bgee; ENSG00000171044; Expressed in buccal mucosa cell and 105 other tissues.
DR ExpressionAtlas; Q5GH73; baseline and differential.
DR Genevisible; Q5GH73; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:1902742; P:apoptotic process involved in development; IBA:GO_Central.
DR GO; GO:0043652; P:engulfment of apoptotic cell; IBA:GO_Central.
DR GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IBA:GO_Central.
DR InterPro; IPR018629; XK-rel.
DR Pfam; PF09815; XK-related; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..641
FT /note="XK-related protein 6"
FT /id="PRO_0000190785"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 473..493
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 20..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..120
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..279
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_014663"
SQ SEQUENCE 641 AA; 71638 MW; DEFFE0EE7CB43C79 CRC64;
MAAKSDGGGV GVGFAQLHNL DEAVGSGGEE DGEPGGGGCG GGGDGSEPGE SSSMHICHCC
NTSSCYWGCR SACLRSLLGR KPRRSAAADG GDQPLQPPAA PGAGRQPPTP SAARPEPPPP
QVERPWLDCL WIVLALLVFF GDVGTDLWLA LDYYRKGDYV YFGLTLFFVL VPSLLVQSLS
FRWFVQDYTG GGLGAVEGLT SRGPPMMGAG YVHGAARGGP GVRVSPTPGA QRLCRLSVWI
WQSVIHLLQM GQVWRYIRTM YLGIQSQRRK EHQRRFYWAM MYEYADVNML RLLETFLESA
PQLVLQLYIM LQKNSAETLP CVSSVTSLMS LAWVLASYHK LLRDSRDDKK SMSYRGAIIQ
VFWRLFTISS RVISFALFAS IFQLYFGIFV VVHWCAMAFW IIHGGTDFCM SKWEEILFNM
VVGIVYIFCW FNVKEGRTRY RMFAYYTIVL TENAALTFLW YFYRDPETTD SYAVPALCCV
FISFVAGIAM MLLYYGVLHP TGPRAKILAS SCCAELLWGI PLPPDVEPMA PEIPGYRGTQ
VTPTRAVTEQ QEDLTADTCL PVFQVRPMGP PTPLGRPYLP EGPLIKIDMP RKRYPAWDAH
FVDRRLRRTI NILQYVTPTA VGIRYRDGPL LYELLQYESS L
