XKR6_MOUSE
ID XKR6_MOUSE Reviewed; 638 AA.
AC E9Q6C8; G3X9Y8; Q5GH65; Q8R1I8;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=XK-related protein 6 {ECO:0000305};
GN Name=Xkr6 {ECO:0000303|PubMed:25231987, ECO:0000312|MGI:MGI:2447765};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 99-638 (ISOFORM 1).
RC STRAIN=C57BL/6J;
RA Huang C.-H., Chen Y.;
RT "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT and invertebrates.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=25231987; DOI=10.1074/jbc.m114.583419;
RA Suzuki J., Imanishi E., Nagata S.;
RT "Exposure of phosphatidylserine by Xk-related protein family members during
RT apoptosis.";
RL J. Biol. Chem. 289:30257-30267(2014).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25231987};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=E9Q6C8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=E9Q6C8-2; Sequence=VSP_042406;
CC Name=3;
CC IsoId=E9Q6C8-3; Sequence=VSP_042407;
CC -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR EMBL; AC118607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC120788; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC024502; AAH24502.1; -; mRNA.
DR EMBL; CH466535; EDL36060.1; -; Genomic_DNA.
DR EMBL; AY534252; AAT07101.1; -; mRNA.
DR CCDS; CCDS27204.2; -. [E9Q6C8-1]
DR RefSeq; NP_775569.2; NM_173393.2. [E9Q6C8-1]
DR RefSeq; XP_006518944.1; XM_006518881.3. [E9Q6C8-3]
DR AlphaFoldDB; E9Q6C8; -.
DR SMR; E9Q6C8; -.
DR STRING; 10090.ENSMUSP00000113708; -.
DR PhosphoSitePlus; E9Q6C8; -.
DR MaxQB; E9Q6C8; -.
DR PaxDb; E9Q6C8; -.
DR PeptideAtlas; E9Q6C8; -.
DR PRIDE; E9Q6C8; -.
DR ProteomicsDB; 299709; -. [E9Q6C8-1]
DR ProteomicsDB; 299710; -. [E9Q6C8-2]
DR ProteomicsDB; 299711; -. [E9Q6C8-3]
DR Antibodypedia; 8456; 40 antibodies from 14 providers.
DR Ensembl; ENSMUST00000119973; ENSMUSP00000113708; ENSMUSG00000035067. [E9Q6C8-1]
DR Ensembl; ENSMUST00000120820; ENSMUSP00000112691; ENSMUSG00000035067. [E9Q6C8-3]
DR GeneID; 219149; -.
DR KEGG; mmu:219149; -.
DR UCSC; uc007uhu.2; mouse. [E9Q6C8-1]
DR CTD; 286046; -.
DR MGI; MGI:2447765; Xkr6.
DR VEuPathDB; HostDB:ENSMUSG00000035067; -.
DR eggNOG; KOG4790; Eukaryota.
DR GeneTree; ENSGT00990000203579; -.
DR HOGENOM; CLU_028534_1_0_1; -.
DR InParanoid; E9Q6C8; -.
DR OMA; VWVWQTI; -.
DR OrthoDB; 1230316at2759; -.
DR PhylomeDB; E9Q6C8; -.
DR TreeFam; TF316454; -.
DR BioGRID-ORCS; 219149; 4 hits in 71 CRISPR screens.
DR PRO; PR:E9Q6C8; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; E9Q6C8; protein.
DR Bgee; ENSMUSG00000035067; Expressed in cerebellum lobe and 187 other tissues.
DR ExpressionAtlas; E9Q6C8; baseline and differential.
DR Genevisible; E9Q6C8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:1902742; P:apoptotic process involved in development; IBA:GO_Central.
DR GO; GO:0043652; P:engulfment of apoptotic cell; IBA:GO_Central.
DR GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IBA:GO_Central.
DR InterPro; IPR018629; XK-rel.
DR Pfam; PF09815; XK-related; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..638
FT /note="XK-related protein 6"
FT /id="PRO_0000415853"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 470..490
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 24..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..112
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..276
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_042406"
FT VAR_SEQ 1..256
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_042407"
SQ SEQUENCE 638 AA; 70928 MW; B89BEB24D3F1A305 CRC64;
MAAKSDGGGV GVGFAQLHNL DEAVGSGEED GEPGGGGCGG GDGSEPGESS SLHICHCCNT
SSCYWGCRSA CLRSLLGKKP RRSAAAADGG DQPLQPPGAA GRHPPTPSAG RPQPASPQVE
RPWLDCLWIV LALLVFFGDV GTDLWLALDY YRKGDYGCFG LTLFFVLVPS LLVQSLSFRW
FVQDYTGGGL GAVEGLSSRG PPMMGAGYGH GAARGGPGAG GSATPGAQRL CRLSVWIWQS
VIHLLQMGQV WRYIRTMYLG IQSQRQKEHQ RRFYWAMMYE YADVNMLRLL ETFLESAPQL
VLQLCIMIQK NSAETLPCVS SVTSLMSLAW VLASYHKLLR DSRDDKKSMS YRGALIHLFW
RLFTISSRVI SFALFASIFQ LYFGIFVVVH WCAMAFWIIH GGTDFCMSKW EEILFNMVVG
IVYIFCWFNV KEGRTRYRMF AYYTIVLTEN AALTFLWYFY RNPESTDSYA VPALCCVFVS
FVAGITLMLL YYGVLHPMGP RAKVFASSCC AELLWGIPLP PDVEPMAPQT PGYRGTQVTP
TRAVTEQQED LTADTCLPVF QVRPMGPSTP SGRPYHPEGP LIKIDMPRKR YPAWDAHFVD
RRLRRTINIL QYVTPTAVGI RYRDGPLLYE LLQYESSL
