ID   XKR6_RAT                Reviewed;         638 AA.
AC   Q5GH57;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=XK-related protein 6 {ECO:0000305};
GN   Name=Xkr6 {ECO:0000312|RGD:1310719}; Synonyms=Xrg6 {ECO:0000303|Ref.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:E9Q6C8};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR   EMBL; AY534260; AAT07109.1; -; mRNA.
DR   RefSeq; NP_001012042.1; NM_001012042.1.
DR   AlphaFoldDB; Q5GH57; -.
DR   SMR; Q5GH57; -.
DR   STRING; 10116.ENSRNOP00000015540; -.
DR   SwissPalm; Q5GH57; -.
DR   PaxDb; Q5GH57; -.
DR   PRIDE; Q5GH57; -.
DR   Ensembl; ENSRNOT00000015540; ENSRNOP00000015540; ENSRNOG00000011634.
DR   GeneID; 305960; -.
DR   KEGG; rno:305960; -.
DR   UCSC; RGD:1310719; rat.
DR   CTD; 286046; -.
DR   RGD; 1310719; Xkr6.
DR   eggNOG; KOG4790; Eukaryota.
DR   GeneTree; ENSGT00990000203579; -.
DR   InParanoid; Q5GH57; -.
DR   OrthoDB; 1230316at2759; -.
DR   PhylomeDB; Q5GH57; -.
DR   PRO; PR:Q5GH57; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:1902742; P:apoptotic process involved in development; IBA:GO_Central.
DR   GO; GO:0043652; P:engulfment of apoptotic cell; IBA:GO_Central.
DR   GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IBA:GO_Central.
DR   InterPro; IPR018629; XK-rel.
DR   Pfam; PF09815; XK-related; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..638
FT                   /note="XK-related protein 6"
FT                   /id="PRO_0000190786"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        470..490
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          24..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          82..117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..112
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   638 AA;  70928 MW;  B89BEB24D3F1A305 CRC64;
     MAAKSDGGGV GVGFAQLHNL DEAVGSGEED GEPGGGGCGG GDGSEPGESS SLHICHCCNT
     SSCYWGCRSA CLRSLLGKKP RRSAAAADGG DQPLQPPGAA GRHPPTPSAG RPQPASPQVE
     RPWLDCLWIV LALLVFFGDV GTDLWLALDY YRKGDYGCFG LTLFFVLVPS LLVQSLSFRW
     FVQDYTGGGL GAVEGLSSRG PPMMGAGYGH GAARGGPGAG GSATPGAQRL CRLSVWIWQS
     VIHLLQMGQV WRYIRTMYLG IQSQRQKEHQ RRFYWAMMYE YADVNMLRLL ETFLESAPQL
     VLQLCIMIQK NSAETLPCVS SVTSLMSLAW VLASYHKLLR DSRDDKKSMS YRGALIHLFW
     RLFTISSRVI SFALFASIFQ LYFGIFVVVH WCAMAFWIIH GGTDFCMSKW EEILFNMVVG
     IVYIFCWFNV KEGRTRYRMF AYYTIVLTEN AALTFLWYFY RNPESTDSYA VPALCCVFVS
     FVAGITLMLL YYGVLHPMGP RAKVFASSCC AELLWGIPLP PDVEPMAPQT PGYRGTQVTP
     TRAVTEQQED LTADTCLPVF QVRPMGPSTP SGRPYHPEGP LIKIDMPRKR YPAWDAHFVD
     RRLRRTINIL QYVTPTAVGI RYRDGPLLYE LLQYESSL