ID   XKR6_TETNG              Reviewed;         578 AA.
AC   Q49LS8; Q4RR79; Q4RR80;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=XK-related protein 6 {ECO:0000305};
GN   Name=xkr6; Synonyms=xrg6 {ECO:0000303|Ref.1};
GN   ORFNames=GSTENG00030285001, GSTENG00030286001;
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:E9Q6C8};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG09102.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAG09103.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY702901; AAU94454.1; -; mRNA.
DR   EMBL; CAAE01015003; CAG09103.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CAAE01015003; CAG09102.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q49LS8; -.
DR   SMR; Q49LS8; -.
DR   STRING; 99883.ENSTNIP00000019426; -.
DR   KEGG; tng:GSTEN00030285G001; -.
DR   KEGG; tng:GSTEN00030286G001; -.
DR   HOGENOM; CLU_028534_1_0_1; -.
DR   InParanoid; Q49LS8; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018629; XK-rel.
DR   Pfam; PF09815; XK-related; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..578
FT                   /note="XK-related protein 6"
FT                   /id="PRO_0000190787"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   578 AA;  65969 MW;  9E0EF423BDEA0674 CRC64;
     MAAKSDGRGV VTGFAQLHNL DEVVGTGEDD ARNGSSFHIC HCCNTSSCYW GCRSACLHYL
     RAKGKGEGKE TARPTPEERL WLDCLWIVLA LLVFFWDVGT DLWLAVDYYH KQDFLWSGLT
     LFFVLVPSVL VQILSFRWFV QDYTGGGLGS VEGLSSRRAA ASLQRDKCCR LSVWIWQTVI
     HIFQLGQVWR YIRTMYLGIQ SHRQKENQRR FYWAMMYEYA DVNMLRLLET FLESAPQLVL
     QLCIMIQSNK AEWLQCVSAL SSLLSLAWVL ASYHKLLRDS RDDKKSMSYR GALVHLFWRL
     FTISSRVLSL ALFASVFHIY FGIFVVLHWC AMAFWVIHGG TDFCMSKWEE VLFNMVVGVV
     YVFCWFNVRE GRTRYRMVAY YVVVLLENVI LTSLWYAYRD PATTDAYASL ALCGVFLCFA
     SGVACMVLYY GVLHPMGPRL RVLASSCCAE LLWGLPLPPE AEPMAPTPGP RGSQATPTRG
     LTGEYAESDE TATDTCLPVF QVRSTEPVDA AGRPIQPEGP FIKIDMPRKR YPAWDAHFVD
     RRLRRTVNVL QYISPNAAGI RYRDGPLLYE LLQYESSL