XKR7_HUMAN
ID XKR7_HUMAN Reviewed; 579 AA.
AC Q5GH72; Q9NUG5;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=XK-related protein 7 {ECO:0000305};
GN Name=XKR7 {ECO:0000312|HGNC:HGNC:23062};
GN Synonyms=C20orf159 {ECO:0000312|HGNC:HGNC:23062}, XRG7 {ECO:0000303|Ref.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Huang C.-H., Chen Y.;
RT "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT and invertebrates.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5GH64};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY534245; AAT07094.1; -; mRNA.
DR EMBL; AL031658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS33459.1; -.
DR RefSeq; NP_001011718.1; NM_001011718.1.
DR AlphaFoldDB; Q5GH72; -.
DR SMR; Q5GH72; -.
DR IntAct; Q5GH72; 2.
DR STRING; 9606.ENSP00000477059; -.
DR iPTMnet; Q5GH72; -.
DR PhosphoSitePlus; Q5GH72; -.
DR BioMuta; XKR7; -.
DR DMDM; 74707816; -.
DR jPOST; Q5GH72; -.
DR MassIVE; Q5GH72; -.
DR PaxDb; Q5GH72; -.
DR PeptideAtlas; Q5GH72; -.
DR PRIDE; Q5GH72; -.
DR ProteomicsDB; 62831; -.
DR Antibodypedia; 71557; 21 antibodies from 11 providers.
DR DNASU; 343702; -.
DR Ensembl; ENST00000562532.3; ENSP00000477059.1; ENSG00000260903.3.
DR GeneID; 343702; -.
DR KEGG; hsa:343702; -.
DR MANE-Select; ENST00000562532.3; ENSP00000477059.1; NM_001011718.2; NP_001011718.1.
DR UCSC; uc002wxe.4; human.
DR CTD; 343702; -.
DR DisGeNET; 343702; -.
DR GeneCards; XKR7; -.
DR HGNC; HGNC:23062; XKR7.
DR HPA; ENSG00000260903; Group enriched (brain, pituitary gland, retina).
DR neXtProt; NX_Q5GH72; -.
DR OpenTargets; ENSG00000260903; -.
DR PharmGKB; PA142670565; -.
DR VEuPathDB; HostDB:ENSG00000260903; -.
DR eggNOG; KOG4790; Eukaryota.
DR GeneTree; ENSGT00990000203579; -.
DR HOGENOM; CLU_028534_1_0_1; -.
DR InParanoid; Q5GH72; -.
DR OMA; RRMTLYH; -.
DR OrthoDB; 1230316at2759; -.
DR PhylomeDB; Q5GH72; -.
DR TreeFam; TF316454; -.
DR PathwayCommons; Q5GH72; -.
DR SignaLink; Q5GH72; -.
DR BioGRID-ORCS; 343702; 17 hits in 1060 CRISPR screens.
DR GenomeRNAi; 343702; -.
DR Pharos; Q5GH72; Tdark.
DR PRO; PR:Q5GH72; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q5GH72; protein.
DR Bgee; ENSG00000260903; Expressed in cortical plate and 44 other tissues.
DR Genevisible; Q5GH72; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:1902742; P:apoptotic process involved in development; IBA:GO_Central.
DR GO; GO:0043652; P:engulfment of apoptotic cell; IBA:GO_Central.
DR GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IBA:GO_Central.
DR InterPro; IPR018629; XK-rel.
DR Pfam; PF09815; XK-related; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..579
FT /note="XK-related protein 7"
FT /id="PRO_0000190788"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 63826 MW; D8D0FF64B9EDD53D CRC64;
MAAKSDGAAA SASPDPEGAA GGARGSAGGR GEAAAAAGPP GVVGAGGPGP RYELRDCCWV
LCALLVFFSD GATDLWLAAS YYLQNQHTYF SLTLLFVLLP SLVVQLLSFR WFVYDYSEPA
GSPGPAVSTK DSVAGGAAIS TKDSAGAFRT KEGSPEPGPQ PAPSSASAYR RRCCRLCIWL
LQTLVHLLQL GQVWRYLRAL YLGLQSRWRG ERLRRHFYWQ MLFESADVSM LRLLETFLRS
APQLVLQLSL LVHRGGAPDL LPALSTSASL VSLAWTLASY QKVLRDSRDD KRPLSYKGAV
AQVLWHLFSI AARGLAFALF ASVYKLYFGI FIVAHWCVMT FWVIQGETDF CMSKWEEIIY
NMVVGIIYIF CWFNVKEGRS RRRMTLYHCI VLLENAALTG FWYSSRNFST DFYSLIMVCV
VASSFALGIF FMCVYYCLLH PNGPMLGPQA PGCIFRKASE PCGPPADAIT SPPRSLPRTT
GAERDGASAG ERAGTPTPPV FQVRPGLPPT PVARTLRTEG PVIRIDLPRK KYPAWDAHFI
DRRLRKTILA LEYSSPATPR LQYRSVGTSQ ELLEYETTV
