XKR7_MOUSE
ID XKR7_MOUSE Reviewed; 580 AA.
AC Q5GH64; A2ATH3;
DT 11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=XK-related protein 7 {ECO:0000305};
GN Name=Xkr7 {ECO:0000303|PubMed:25231987, ECO:0000312|MGI:MGI:3526711};
GN Synonyms=Xrg7 {ECO:0000303|Ref.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Huang C.-H., Chen Y.;
RT "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT and invertebrates.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=25231987; DOI=10.1074/jbc.m114.583419;
RA Suzuki J., Imanishi E., Nagata S.;
RT "Exposure of phosphatidylserine by Xk-related protein family members during
RT apoptosis.";
RL J. Biol. Chem. 289:30257-30267(2014).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25231987};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR EMBL; AY534253; AAT07102.1; -; mRNA.
DR EMBL; AL928862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS16905.1; -.
DR RefSeq; NP_001011732.1; NM_001011732.1.
DR RefSeq; XP_006499383.1; XM_006499320.3.
DR AlphaFoldDB; Q5GH64; -.
DR SMR; Q5GH64; -.
DR BioGRID; 230770; 1.
DR STRING; 10090.ENSMUSP00000049346; -.
DR iPTMnet; Q5GH64; -.
DR PhosphoSitePlus; Q5GH64; -.
DR MaxQB; Q5GH64; -.
DR PaxDb; Q5GH64; -.
DR PeptideAtlas; Q5GH64; -.
DR PRIDE; Q5GH64; -.
DR ProteomicsDB; 299796; -.
DR Antibodypedia; 71557; 21 antibodies from 11 providers.
DR DNASU; 228787; -.
DR Ensembl; ENSMUST00000037235; ENSMUSP00000049346; ENSMUSG00000042631.
DR GeneID; 228787; -.
DR KEGG; mmu:228787; -.
DR UCSC; uc008nha.1; mouse.
DR CTD; 343702; -.
DR MGI; MGI:3526711; Xkr7.
DR VEuPathDB; HostDB:ENSMUSG00000042631; -.
DR eggNOG; KOG4790; Eukaryota.
DR GeneTree; ENSGT00990000203579; -.
DR HOGENOM; CLU_028534_1_0_1; -.
DR InParanoid; Q5GH64; -.
DR OMA; RRMTLYH; -.
DR OrthoDB; 1230316at2759; -.
DR PhylomeDB; Q5GH64; -.
DR TreeFam; TF316454; -.
DR BioGRID-ORCS; 228787; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q5GH64; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q5GH64; protein.
DR Bgee; ENSMUSG00000042631; Expressed in embryonic brain and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:1902742; P:apoptotic process involved in development; IBA:GO_Central.
DR GO; GO:0043652; P:engulfment of apoptotic cell; IBA:GO_Central.
DR GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; IBA:GO_Central.
DR InterPro; IPR018629; XK-rel.
DR Pfam; PF09815; XK-related; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..580
FT /note="XK-related protein 7"
FT /id="PRO_0000190789"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 384..404
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 580 AA; 64302 MW; F3291FABF4C5A826 CRC64;
MAAKSDGAAA VAGPGPEGPA GADRGGAGGR GEAAAGIAGP GPVEAGCPGP RYELRDCCWV
LCALLVFFSD GATDLWLAAS YYLQGQSTYF GLTLLFVLLP SLVVQLLSFR WFVYDYSEPA
GTPGPAVSTK DSDIVGAAIS TKDSAVAFRT KEGSAELVPR PAPSSAGTYR RRCCRLCVWL
LQTLVHLLQL GQVWRYLRAL YLGLQSRWRG ERLRRHFYWQ MLFESADVSM LRLLETFLRS
APQLVLQLSL LVHRGREPEL LTALSISASL VSLAWTLASY QKVLRDSRDD KRPLSYKGAV
VQVLWHLFTI AARTLAFALF ASVYKLYFGI FIVAHWCIMT FWVIQGETDF CMSKWEEIIY
NMVVGIIYIF CWFNVKEGRS RRRVTLYYCI VLLENAALTG FWYSSRNFST DFYSLILVCV
VASSFALGIF FMCVYYCLLH PNGPMLGPQA PGCIFPEAPG PCGPPADAIT SPPRSLPRTT
GTERDGVAVG GERAGTPTLP VFQVRPGLPP TPVARPLRTE GPVIRIDLPR KKYPAWDAHF
IDRRLRKTIL ALEYSSPATP RLQYRSMGTS QELLEYETTV
