ID   XKR8_GASAC              Reviewed;         404 AA.
AC   Q4VV71;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=XK-related protein 8 {ECO:0000305};
GN   Name=xkr8 {ECO:0000250|UniProtKB:Q9H6D3};
GN   Synonyms=xrg8 {ECO:0000303|Ref.1};
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Phospholipid scramblase that promotes phosphatidylserine
CC       exposure on apoptotic cell surface, possibly by mediating phospholipid
CC       scrambling. Phosphatidylserine is a specific marker only present at the
CC       surface of apoptotic cells and acts as a specific signal for
CC       engulfment. {ECO:0000250|UniProtKB:Q9H6D3}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-
CC         sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663,
CC         ChEBI:CHEBI:57262; Evidence={ECO:0000250|UniProtKB:Q9H6D3};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H6D3};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR   EMBL; AY613957; AAU81654.1; -; mRNA.
DR   RefSeq; NP_001254570.1; NM_001267641.1.
DR   AlphaFoldDB; Q4VV71; -.
DR   SMR; Q4VV71; -.
DR   STRING; 69293.ENSGACP00000003106; -.
DR   GeneID; 100174881; -.
DR   KEGG; gat:100174881; -.
DR   eggNOG; KOG4790; Eukaryota.
DR   InParanoid; Q4VV71; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0043652; P:engulfment of apoptotic cell; ISS:UniProtKB.
DR   GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; ISS:UniProtKB.
DR   InterPro; IPR018629; XK-rel.
DR   Pfam; PF09815; XK-related; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..404
FT                   /note="XK-related protein 8"
FT                   /id="PRO_0000190794"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        262..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        324..344
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   404 AA;  46385 MW;  21B29DADFF9CF2EF CRC64;
     MEGATFSKYS WIDFVFSVIG ACTFLVDWGS DVWLAAEFYR RGDVTWFWVL VGLMALSSFV
     VQTFSWFWFQ YDRELPGFRA QTEAAAVLLG DRAKLSCAVH VLQLGFLCRH ISAIRQGFRV
     WWRKEKGSEY AIYQTHDLSM LRLIETFCES APQLTLMIYV MLHTHKARAV QFVSIAASTT
     SIAWMVVDYH RSLRSFLPDK AKQGWGSSLI YFLWNLLLIA PRVAALALCA SVLSGYMAAH
     FLMLWSAFAL WAWRQGTHFM DSVAGEWLYR ATVGLIWYFS WFNVKDGQTR SRSAIYHSFI
     STDGAILLAT WWCHRDPVQT QSYALALLIA LPLFHFLGLL FKALYYCCFH PKLWRPPARD
     PGLPNDLPDA QVSMRDFPIQ DGGLSPKLLN KRMAGQVARF YSDE