ID   XKR8_TETNG              Reviewed;         404 AA.
AC   Q49LS7; Q4SYX9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=XK-related protein 8 {ECO:0000305};
GN   Name=xkr8 {ECO:0000250|UniProtKB:Q9H6D3};
GN   Synonyms=xrg8 {ECO:0000303|Ref.1}; ORFNames=GSTENG00010111001;
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- FUNCTION: Phospholipid scramblase that promotes phosphatidylserine
CC       exposure on apoptotic cell surface, possibly by mediating phospholipid
CC       scrambling. Phosphatidylserine is a specific marker only present at the
CC       surface of apoptotic cells and acts as a specific signal for
CC       engulfment. {ECO:0000250|UniProtKB:Q9H6D3}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-
CC         sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663,
CC         ChEBI:CHEBI:57262; Evidence={ECO:0000250|UniProtKB:Q9H6D3};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H6D3};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAF94153.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY702902; AAU94455.1; -; mRNA.
DR   EMBL; CAAE01011909; CAF94153.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q49LS7; -.
DR   SMR; Q49LS7; -.
DR   TCDB; 2.A.112.1.17; the kx blood-group antigen (kxa) family.
DR   Ensembl; ENSTNIT00000006558; ENSTNIP00000006409; ENSTNIG00000003808.
DR   KEGG; tng:GSTEN00010111G001; -.
DR   GeneTree; ENSGT01050000244963; -.
DR   HOGENOM; CLU_028534_2_1_1; -.
DR   InParanoid; Q49LS7; -.
DR   OMA; GYLYRCL; -.
DR   TreeFam; TF316454; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0043652; P:engulfment of apoptotic cell; ISS:UniProtKB.
DR   GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; ISS:UniProtKB.
DR   InterPro; IPR018629; XK-rel.
DR   Pfam; PF09815; XK-related; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..404
FT                   /note="XK-related protein 8"
FT                   /id="PRO_0000190795"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        263..283
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   404 AA;  46566 MW;  68DF8F730715D07B CRC64;
     MEQPSIYNYS WVDFVFSVIG VFTFFVDWGA DVWVATEFYR RGDFFWFGVL VGLMVLSSVL
     VQMFSWFWLQ YDRGLPDLQT GGGTVLFGDR LRLSCLLHVL QLGFLCRHIS AIRQGFRVWW
     RKEEGSEYAF YLSHDLSMLR LIETFSESAP QLTLMIYVML RTQRARAVQF VSVAASTTSI
     AWMVVDYHRC LRSFLPDKAR QGWASSLIYF LWNLLLIAPR VAALALFASV VGGYLGLHLL
     LLWLVFVTWA WLQRTHFMDS PGGEWLYRAT VGIIWYFSWF NVAEGRTRGR SAIYHAFITA
     DGAILLVTWW CCREPVQAEP YALALLLTLL LSYLLGLLFK SLYYCCFHPT LWRPPAREPG
     LPDDLPDADV TFRHLSIQDG APASRPLNRR MALHAADFYS ARTS