ID   XKR9_PANTR              Reviewed;         373 AA.
AC   Q49LR9;
DT   11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=XK-related protein 9 {ECO:0000305};
DE   Contains:
DE     RecName: Full=XK-related protein 9, processed form {ECO:0000250|UniProtKB:Q5GH62};
GN   Name=XKR9 {ECO:0000250|UniProtKB:Q5GH70};
GN   Synonyms=XRG9 {ECO:0000303|Ref.1};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: [XK-related protein 9, processed form]: Phospholipid
CC       scramblase that promotes phosphatidylserine exposure on apoptotic cell
CC       surface. Phosphatidylserine is a specific marker only present at the
CC       surface of apoptotic cells and acts as a specific signal for
CC       engulfment. {ECO:0000250|UniProtKB:Q5GH62}.
CC   -!- CATALYTIC ACTIVITY: [XK-related protein 9, processed form]:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-
CC         sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663,
CC         ChEBI:CHEBI:57262; Evidence={ECO:0000250|UniProtKB:Q5GH62};
CC   -!- ACTIVITY REGULATION: Activated upon caspase cleavage to generate the
CC       XK-related protein 9, processed form. Does not act prior the onset of
CC       apoptosis. {ECO:0000250|UniProtKB:Q5GH62}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5GH62};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- PTM: [XK-related protein 9]: Undergoes proteolytic processing by
CC       caspase-3 (CASP3), caspase-6 (CASP6) and caspase-7 (CASP7) to generate
CC       the XK-related protein 9, processed form, leading to its activation.
CC       {ECO:0000250|UniProtKB:Q5GH62}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR   EMBL; AY702912; AAV83785.1; -; mRNA.
DR   RefSeq; NP_001028210.1; NM_001033038.1.
DR   RefSeq; XP_009453610.1; XM_009455335.2.
DR   AlphaFoldDB; Q49LR9; -.
DR   SMR; Q49LR9; -.
DR   STRING; 9598.ENSPTRP00000053139; -.
DR   PaxDb; Q49LR9; -.
DR   Ensembl; ENSPTRT00000059886; ENSPTRP00000053139; ENSPTRG00000030985.
DR   GeneID; 613219; -.
DR   KEGG; ptr:613219; -.
DR   CTD; 389668; -.
DR   VGNC; VGNC:2451; XKR9.
DR   eggNOG; KOG4790; Eukaryota.
DR   GeneTree; ENSGT01050000244963; -.
DR   HOGENOM; CLU_028534_2_0_1; -.
DR   InParanoid; Q49LR9; -.
DR   OMA; VSMEFLY; -.
DR   OrthoDB; 1230316at2759; -.
DR   TreeFam; TF316454; -.
DR   Proteomes; UP000002277; Chromosome 8.
DR   Bgee; ENSPTRG00000030985; Expressed in testis and 5 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0017128; F:phospholipid scramblase activity; ISS:UniProtKB.
DR   GO; GO:1902742; P:apoptotic process involved in development; IBA:GO_Central.
DR   GO; GO:0043652; P:engulfment of apoptotic cell; IBA:GO_Central.
DR   GO; GO:0070782; P:phosphatidylserine exposure on apoptotic cell surface; ISS:UniProtKB.
DR   InterPro; IPR018629; XK-rel.
DR   Pfam; PF09815; XK-related; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..373
FT                   /note="XK-related protein 9"
FT                   /id="PRO_0000190798"
FT   CHAIN           1..357
FT                   /note="XK-related protein 9, processed form"
FT                   /evidence="ECO:0000250|UniProtKB:Q5GH62"
FT                   /id="PRO_0000453295"
FT   TRANSMEM        8..28
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        318..338
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   SITE            357..358
FT                   /note="Cleavage; by caspase-3, caspase-6 and caspase-7"
FT                   /evidence="ECO:0000250|UniProtKB:Q5GH62"
SQ   SEQUENCE   373 AA;  43419 MW;  E6AC5A892FED7877 CRC64;
     MKYTKQNFMM SVLGIIIYVT DLIVDIWVSV RFFHEGQYVF SALALSFMLF GTLVAQCFSY
     SWFKADLKKA GQESQHCFLL LHCLQGGVFT RYWFALKRGY HAAFKYDSNT SNFVEEQIDL
     HKEVIDRVTD LSMLRLFETY LEGCPQLILQ LYILLEHGQA NFSQYAAIMV SCCAISWSTV
     DYQVALRKSL PDKKLLNGLC PKITYLFYKL FTLLSWMLSV VLLLFLNVKI ALFLLLFLWL
     LGIIWAFKNN TQFCTCISME FLYRIVVGFI LIFTFFNIKG QNTKCPMSCY YIVRVLGTLG
     ILTVFWVCPL NIFNPDYFIP ISITIVLTLL LGILFLIVYY GSFHPNRSAE TKCDEIDGKP
     VLRECRMRYF LME