ID   XKR9_TETNG              Reviewed;         380 AA.
AC   Q49LS6; Q4SMU6;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=XK-related protein 9 {ECO:0000305};
GN   Name=xkr9 {ECO:0000250|UniProtKB:Q5GH70};
GN   Synonyms=xrg9 {ECO:0000303|Ref.1};
GN   ORFNames=GSTENG00015586001 {ECO:0000303|PubMed:15496914};
OS   Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon
OS   nigroviridis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Tetraodon.
OX   NCBI_TaxID=99883;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Huang C.-H., Chen Y.;
RT   "A superfamily of XK-related genes (XRG) widely expressed in vertebrates
RT   and invertebrates.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15496914; DOI=10.1038/nature03025;
RA   Jaillon O., Aury J.-M., Brunet F., Petit J.-L., Stange-Thomann N.,
RA   Mauceli E., Bouneau L., Fischer C., Ozouf-Costaz C., Bernot A., Nicaud S.,
RA   Jaffe D., Fisher S., Lutfalla G., Dossat C., Segurens B., Dasilva C.,
RA   Salanoubat M., Levy M., Boudet N., Castellano S., Anthouard V., Jubin C.,
RA   Castelli V., Katinka M., Vacherie B., Biemont C., Skalli Z., Cattolico L.,
RA   Poulain J., De Berardinis V., Cruaud C., Duprat S., Brottier P.,
RA   Coutanceau J.-P., Gouzy J., Parra G., Lardier G., Chapple C.,
RA   McKernan K.J., McEwan P., Bosak S., Kellis M., Volff J.-N., Guigo R.,
RA   Zody M.C., Mesirov J., Lindblad-Toh K., Birren B., Nusbaum C., Kahn D.,
RA   Robinson-Rechavi M., Laudet V., Schachter V., Quetier F., Saurin W.,
RA   Scarpelli C., Wincker P., Lander E.S., Weissenbach J., Roest Crollius H.;
RT   "Genome duplication in the teleost fish Tetraodon nigroviridis reveals the
RT   early vertebrate proto-karyotype.";
RL   Nature 431:946-957(2004).
CC   -!- FUNCTION: Phospholipid scramblase that promotes phosphatidylserine
CC       exposure on apoptotic cell surface. Phosphatidylserine is a specific
CC       marker only present at the surface of apoptotic cells and acts as a
CC       specific signal for engulfment. {ECO:0000250|UniProtKB:Q5GH62}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-
CC         sn-glycero-3-phospho-L-serine(out); Xref=Rhea:RHEA:38663,
CC         ChEBI:CHEBI:57262; Evidence={ECO:0000250|UniProtKB:Q5GH62};
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5GH62};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAF98036.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AY702903; AAU94456.1; -; mRNA.
DR   EMBL; CAAE01014544; CAF98036.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q49LS6; -.
DR   SMR; Q49LS6; -.
DR   STRING; 99883.ENSTNIP00000011017; -.
DR   KEGG; tng:GSTEN00015586G001; -.
DR   HOGENOM; CLU_028534_2_0_1; -.
DR   InParanoid; Q49LS6; -.
DR   Proteomes; UP000007303; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR018629; XK-rel.
DR   Pfam; PF09815; XK-related; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..380
FT                   /note="XK-related protein 9"
FT                   /id="PRO_0000190799"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        167..187
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   380 AA;  43105 MW;  33647B88180C783F CRC64;
     MTEFTKLRWL LSAAGLVMYV ADVCTDAALV LTYFKEKHVV CAALTLLFIV VGLLVTQVFS
     TAWYWDDMDC DEKREDMKTT LPVVSKRGLA TLHLFGVGIF IRYYQMLKRG FGVAWGTVEP
     VEEIKNQQHF LFGLAADLSM LRLLEAFLES VPQLLLQLYI VLGQQECSLV QLVGMSFSFM
     NAAWALVDYR RCLRRSLPDV RQMPRGLPTA IYLLYKLFTI TSRVLGYALL LIFSIYSTVG
     LAIVWLLGTA WTHRLHTDFC SSQSLEFLYR AIVGVILTFT FFNVKGQGTR DAMITYYFLH
     SLINVLSLLL LFVLRPDLLT LAALLCVSTL MAACSVLGLV CLVLYYLLLH PTEACREADE
     VDGLEIKTRS KGRLRDFLYP