ID   XKRY_HUMAN              Reviewed;         159 AA.
AC   O14609;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Testis-specific XK-related protein, Y-linked;
GN   Name=XKRY; Synonyms=XKRY1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9381176; DOI=10.1126/science.278.5338.675;
RA   Lahn B.T., Page D.C.;
RT   "Functional coherence of the human Y chromosome.";
RL   Science 278:675-680(1997).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Testis specific.
CC   -!- SIMILARITY: Belongs to the XK family. {ECO:0000305}.
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DR   EMBL; AF000997; AAC51844.1; -; mRNA.
DR   RefSeq; NP_004668.2; NM_004677.2.
DR   AlphaFoldDB; O14609; -.
DR   BioGRID; 114538; 1.
DR   BioMuta; HGNC:18571; -.
DR   PRIDE; O14609; -.
DR   DNASU; 9082; -.
DR   GeneID; 9082; -.
DR   CTD; 9082; -.
DR   DisGeNET; 9082; -.
DR   GeneCards; XKRY; -.
DR   GeneReviews; XKRY; -.
DR   HGNC; HGNC:18571; XKRY.
DR   MIM; 400015; gene.
DR   neXtProt; NX_O14609; -.
DR   PharmGKB; PA38583; -.
DR   PhylomeDB; O14609; -.
DR   PathwayCommons; O14609; -.
DR   SignaLink; O14609; -.
DR   BioGRID-ORCS; 9082; 10 hits in 158 CRISPR screens.
DR   GenomeRNAi; 9082; -.
DR   Pharos; O14609; Tdark.
DR   PRO; PR:O14609; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; O14609; protein.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007338; P:single fertilization; TAS:ProtInc.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..159
FT                   /note="Testis-specific XK-related protein, Y-linked"
FT                   /id="PRO_0000190771"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        45..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   159 AA;  18083 MW;  B9E81DD842DEF0AB CRC64;
     MFIFNSIADD IFPLISCVGA IHCNILAIRT GNDFAAIKLQ VIKLIYLMIW HSLVIISPVV
     TLAFFPASLK QGSLHFLLII YFVLLLTPWL EFSKSGTHLP SNTKIIPAWW VSMDAYLNHA
     SICCHQFSCL SAVKLQLSNE ELIRDTRWDI QSYTTDFSF