XKS1_ARTOC
ID XKS1_ARTOC Reviewed; 570 AA.
AC C5FSW4;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 03-AUG-2022, entry version 53.
DE RecName: Full=Probable D-xylulose kinase A;
DE Short=Xylulokinase A;
DE EC=2.7.1.17;
GN Name=xkiA; ORFNames=MCYG_05786;
OS Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX NCBI_TaxID=554155;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4605 / CBS 113480;
RX PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT "Comparative genome analysis of Trichophyton rubrum and related
RT dermatophytes reveals candidate genes involved in infection.";
RL MBio 3:E259-E259(2012).
CC -!- FUNCTION: Highly specific D-xylulose kinase which participates in the
CC catabolism of xylose. Xylose is a major component of hemicelluloses
CC such as xylan. Most fungi utilize D-xylose via three enzymatic
CC reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and
CC xylulokinase, to form xylulose 5-phosphate, which enters pentose
CC phosphate pathway (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-xylulose = ADP + D-xylulose 5-phosphate + H(+);
CC Xref=Rhea:RHEA:10964, ChEBI:CHEBI:15378, ChEBI:CHEBI:17140,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57737, ChEBI:CHEBI:456216;
CC EC=2.7.1.17;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- INDUCTION: By D-xylose, L-arabinose or L-arabitol.
CC -!- SIMILARITY: Belongs to the FGGY kinase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS995705; EEQ32967.1; -; Genomic_DNA.
DR RefSeq; XP_002845917.1; XM_002845871.1.
DR AlphaFoldDB; C5FSW4; -.
DR SMR; C5FSW4; -.
DR STRING; 63405.XP_002845917.1; -.
DR EnsemblFungi; EEQ32967; EEQ32967; MCYG_05786.
DR GeneID; 9224217; -.
DR eggNOG; KOG2531; Eukaryota.
DR HOGENOM; CLU_016149_5_0_1; -.
DR OMA; QHGTVFW; -.
DR OrthoDB; 592116at2759; -.
DR Proteomes; UP000002035; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004856; F:xylulokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
DR CDD; cd07776; FGGY_D-XK_euk; 1.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018485; Carb_kinase_FGGY_C.
DR InterPro; IPR042024; D-XK_euk.
DR Pfam; PF02782; FGGY_C; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Carbohydrate metabolism; Cytoplasm; Kinase;
KW Nucleotide-binding; Reference proteome; Transferase; Xylose metabolism.
FT CHAIN 1..570
FT /note="Probable D-xylulose kinase A"
FT /id="PRO_0000393525"
FT BINDING 98
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 279
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 280
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 363
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 470..471
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT BINDING 474
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 570 AA; 62891 MW; 30B542C940D3778D CRC64;
MGSSGGPLYI GFDLSTQQLK GLVVSSDLKV VHIAKFDFDS DSKGFNISKG VLTNEDEGEV
FAPVAMWLQA LDAVLQDLKH QGLDFSLVRG ISGAGQQHGS VYWNESAEEI LGGLDGGKTL
EDQLQQALSY PYSPNWQDSS TQRECDEFDA FLGSEEELAR VTGSKAHHIL RFQRKHPDAY
RKTSRISLVS SFLASIFLGS VAPFDISDVC GMNLWDMPMN RWNERLLKLC AGEAGPEELK
KKLGDVPHDG GQELGKISSY FAKRYSFHPD CAITPSTGDN PATILALPLR PLDAMVSLGT
STTFLMSTPQ YKPDPSTHFF NHPTTPGLYM FMLCYKNGGL AREQVRDAIN ATSGEKTDPS
NPWSNFDRVL LETPPGGQKA GSGPMKMGLF FPRPEIVPNL GEGEWHFNYT PGQANEELKE
TDEGWTHPRD DARAIVESQF LSLRLRSKEL VHSPSGGVPP QPRRIYLVGG GSRNAAIAKV
AGEVLGGIEG VYKLDVGENA CALGAAYKAV WALERAPDQT FEDLIGRRWR EDEFVEKIAD
GFQPDIFEKY RQAVQGFEKM EKQVLMEAKQ