ID   CAP3C_STREE             Reviewed;         306 AA.
AC   Q54800; Q54612;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE            EC=2.7.7.9;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase;
DE   AltName: Full=UDP-glucose pyrophosphorylase;
DE            Short=UDPGP;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase;
GN   Name=cap3C; Synonyms=cps3U;
OS   Streptococcus pneumoniae.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1313;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=406 / Type 3;
RX   PubMed=8566758; DOI=10.1016/0378-1119(95)00657-5;
RA   Arrecubieta C., Garcia E., Lopez R.;
RT   "Sequence and transcriptional analysis of a DNA region involved in the
RT   production of capsular polysaccharide in Streptococcus pneumoniae type 3.";
RL   Gene 167:1-7(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WU2 / Serotype 3;
RX   PubMed=7869055; DOI=10.1084/jem.181.3.973;
RA   Dillard J.P., Vandersea M.W., Yother J.;
RT   "Characterization of the cassette containing genes for type 3 capsular
RT   polysaccharide biosynthesis in Streptococcus pneumoniae.";
RL   J. Exp. Med. 181:973-983(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC         alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:58885; EC=2.7.7.9;
CC   -!- PATHWAY: Carbohydrate metabolism; nucleotide-sugar metabolism.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR   EMBL; Z47210; CAA87405.1; -; Genomic_DNA.
DR   EMBL; U15171; AAC43313.1; -; Genomic_DNA.
DR   RefSeq; WP_000756065.1; NZ_QQIH01000001.1.
DR   AlphaFoldDB; Q54800; -.
DR   SMR; Q54800; -.
DR   PRIDE; Q54800; -.
DR   BRENDA; 2.7.7.9; 1960.
DR   UniPathway; UPA00215; -.
DR   UniPathway; UPA00934; -.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   CDD; cd02541; UGPase_prokaryotic; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43197; PTHR43197; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01099; galU; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Exopolysaccharide synthesis;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..306
FT                   /note="UTP--glucose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000201365"
FT   CONFLICT        204
FT                   /note="N -> H (in Ref. 2; AAC43313)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   306 AA;  33919 MW;  F8E243D00F47EEA8 CRC64;
     MKKVKKAVIP AAGLGTRFLP ATKALAKEML PIVDRPTIHF VIEEALRSGI EDILVVTGKS
     KRSIEDYFDS TFELEYSLRK QGKMELLKSV NESTDIKVHF VRQSSPRGLG DAVLQAKSFV
     GDDPFVVMLG DDLMDITDST AVPLTRQLMD DYNATQASTI AVMPVRYEDV SSYGVISPRL
     ESSNGLYSVD AFVEKPKPEE APSNLAIIGR YLLTPEIFSI LETQKPGAGN EIQLTDAIDT
     LNKTQSVFAR EFVGKRYDVG DKFNFMKTSI DYALQHPQIK ESLKNYVIAL GKQLEKLDDC
     SSSGHL