XLF1_SCHPO
ID XLF1_SCHPO Reviewed; 203 AA.
AC Q9P7J2;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Xrcc4-like factor 1;
DE AltName: Full=Meiotically up-regulated gene 104 protein;
DE AltName: Full=Non-homologous end-joining protein 1;
GN Name=xlf1; Synonyms=mug104, nej1; ORFNames=SPCC24B10.14c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
RN [3]
RP FUNCTION.
RX PubMed=17151234; DOI=10.1534/genetics.106.067850;
RA Cavero S., Chahwan C., Russell P.;
RT "Xlf1 is required for DNA repair by nonhomologous end joining in
RT Schizosaccharomyces pombe.";
RL Genetics 175:963-967(2007).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Involved in non-homologous end joining (NHEJ) in the repair
CC of double-strand DNA breaks (DSB). Has a role in meiosis.
CC {ECO:0000269|PubMed:16303567, ECO:0000269|PubMed:17151234}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the XRCC4-XLF family. XLF subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329672; CAB76223.1; -; Genomic_DNA.
DR PIR; T50421; T50421.
DR RefSeq; NP_588017.1; NM_001023008.2.
DR AlphaFoldDB; Q9P7J2; -.
DR BioGRID; 275768; 10.
DR STRING; 4896.SPCC24B10.14c.1; -.
DR iPTMnet; Q9P7J2; -.
DR PaxDb; Q9P7J2; -.
DR PRIDE; Q9P7J2; -.
DR EnsemblFungi; SPCC24B10.14c.1; SPCC24B10.14c.1:pep; SPCC24B10.14c.
DR PomBase; SPCC24B10.14c; xlf1.
DR VEuPathDB; FungiDB:SPCC24B10.14c; -.
DR eggNOG; ENOG502RNP9; Eukaryota.
DR HOGENOM; CLU_1283923_0_0_1; -.
DR OMA; SKLIWFP; -.
DR PRO; PR:Q9P7J2; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0032807; C:DNA ligase IV complex; IBA:GO_Central.
DR GO; GO:0070419; C:nonhomologous end joining complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0003677; F:DNA binding; IDA:PomBase.
DR GO; GO:0045027; F:DNA end binding; IBA:GO_Central.
DR GO; GO:0006302; P:double-strand break repair; IMP:PomBase.
DR GO; GO:0097680; P:double-strand break repair via classical nonhomologous end joining; IMP:PomBase.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IGI:PomBase.
DR Gene3D; 2.170.210.10; -; 1.
DR InterPro; IPR015381; XLF_N.
DR InterPro; IPR038051; XRCC4-like_N_sf.
DR Pfam; PF09302; XLF; 1.
PE 1: Evidence at protein level;
KW DNA damage; DNA repair; Nucleus; Reference proteome.
FT CHAIN 1..203
FT /note="Xrcc4-like factor 1"
FT /id="PRO_0000116816"
SQ SEQUENCE 203 AA; 23434 MW; 00094EB0FBCA0E43 CRC64;
MSWVQLRGHR FHFIQASFDA ESNEAVQVIH ITDLVRVWSC TCSRNQIVNQ AESERCPIDP
FQTFETLVDV LAEVLVNVSS ESRIQLRGSN DEGSLKIFCT SKIAKDIFLE WNWTLWLTPP
ETIAKMVWFP LINHHLFESE TDTSPGSLMS IIRDQKSLLN DKTWFKEALN ERSSSSNPST
PRKRSAFADI ISPKRPRTRY DFV
