XLNR_ASPCL
ID XLNR_ASPCL Reviewed; 978 AA.
AC A1C7P9;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 2.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Xylanolytic transcriptional activator xlnR;
DE AltName: Full=Xylanase regulator;
GN Name=xlnR; ORFNames=ACLA_074570;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Transcriptional activator of the xylanolytic system. Involved
CC in the regulation of extracellular cellulolytic and xylanolytic genes
CC and in the regulation of the intracellular activities of D-xylose
CC catabolic genes in the pentose catabolic pathway (PCP) in response to
CC the presence of D-xylose (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- SIMILARITY: Belongs to the xlnR/xlr1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAW14420.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; DS027045; EAW14420.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_001275846.1; XM_001275845.1.
DR AlphaFoldDB; A1C7P9; -.
DR STRING; 5057.CADACLAP00006304; -.
DR EnsemblFungi; EAW14420; EAW14420; ACLA_074570.
DR GeneID; 4707549; -.
DR KEGG; act:ACLA_074570; -.
DR eggNOG; ENOG502QUI0; Eukaryota.
DR OrthoDB; 1430629at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0045493; P:xylan catabolic process; ISS:UniProtKB.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc.
FT CHAIN 1..978
FT /note="Xylanolytic transcriptional activator xlnR"
FT /id="PRO_0000393148"
FT DNA_BIND 140..166
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 53..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 978 AA; 106488 MW; 4EF80E9CCF68E95B CRC64;
MSTTSVQHFA PSYPPFSSGL SSNRMAQSQT PGLDTLAEGS QYALEQLQLS REAAAGDTTA
TAASGPSDPM SKSKDPYDFD HHNHNHHNHH NNNHHPNSNS NNSLPGFKNP AQRDPLAEAR
SAIRKNSSSA PVRRRISRAC DQCNQLRTRC DGQNPCAHCI EFGLTCEYAR ERKKRGKASK
KDLAAAAAAA TATPGQPNEN PGKDSGTMVG GHSPPDRRQE LNGRYDPAFD AARNLSGSAQ
PQLPHAEGPG MVGMPNTQHL PSPSQPPMGG GLEGLPMNGY NGLNDSNRPP IPVSELQSLH
MLHSSNPHPR SPPSILPSQR YNGGYNENAY SLMNPQEHNP TPMNQFRLGN STENPPNTFL
GLSPPAQSPG WLPLPSPSPA NFPSFSMASF STTLRYPVLH PVLPHIASII PQSLACDLLD
VYFTSSSSSH LSPQSPYVVG YIFRKQSFLH PTKPRACSPG LLASMLWVAA QTSDAPFLTS
PPSARGRVCQ KLLELTVGLL RPLIHGPAPG ETSPNYAANM VINGIALGGF GVSMDQLGAQ
SSATGAVDDV ATYVHLATVI SASEYKAASM RWWTAAWSLA RELKLGRELP PNTSQTRQDG
ERENDPDADP SNRHSPSLIT AMGHGPGNTV INVTEDEREE RRRLWWLLYA TDRHLALCYN
RPLTLLDKEC NGLLQPMNDD LWQASDFASA SYRQAGPPLE CSGHSMFGYF LPLMTILGEI
IDLQQARNHP RFGLAFRGSP ECDAQVLEIA RQLDLYAQTL KEFETRYTSG LALGAADNDT
AMEGSHLNHV SPSGRSSSTV DSRVNESIVH TKMVVAYGTH IMHVLHILLA GKWDPINLLD
DNDLWISSES FIAAMGHAVG AAEAAADILE YDPDLSFMPF FFGIYLLQGS FLLLLTADKL
QGDASPSVVR ACETIVRAHE ACVVTLNTEY QRTFRKVMRS ALAQVRGRLP EDFGEQQQRR
REVLALYRWT GDGSGLAL
