XLNR_ASPFC
ID XLNR_ASPFC Reviewed; 954 AA.
AC B0XUL1;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Xylanolytic transcriptional activator xlnR;
DE AltName: Full=Xylanase regulator;
GN Name=xlnR; ORFNames=AFUB_031270;
OS Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=451804;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Transcriptional activator of the xylanolytic system. Involved
CC in the regulation of extracellular cellulolytic and xylanolytic genes
CC and in the regulation of the intracellular activities of D-xylose
CC catabolic genes in the pentose catabolic pathway (PCP) in response to
CC the presence of D-xylose (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC -!- SIMILARITY: Belongs to the xlnR/xlr1 family. {ECO:0000305}.
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DR EMBL; DS499595; EDP55066.1; -; Genomic_DNA.
DR AlphaFoldDB; B0XUL1; -.
DR SMR; B0XUL1; -.
DR EnsemblFungi; EDP55066; EDP55066; AFUB_031270.
DR VEuPathDB; FungiDB:AFUB_031270; -.
DR HOGENOM; CLU_006123_1_0_1; -.
DR PhylomeDB; B0XUL1; -.
DR Proteomes; UP000001699; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0045493; P:xylan catabolic process; ISS:UniProtKB.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Metal-binding; Nucleus; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..954
FT /note="Xylanolytic transcriptional activator xlnR"
FT /id="PRO_0000393149"
FT DNA_BIND 119..145
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 51..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 572..590
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 954 AA; 103941 MW; 5C2DC46DEA2B9814 CRC64;
MSTTSLQHFP HSYSPFSSSR SLNRMAQSQT SGLDTLAEGS QYALEQLQMS REAAGSGEAT
DSVGKPKDQF QVDNDNHHNN HSLSNFKNPS QRDPLVEARS TIRKNSASAP VRRRISRACD
QCNQLRTKCD GQNPCAHCIE FGLTCEYARE RKKRGKASKK DLAAAAAAAA AAATNSGQPN
GSSGKEDAAL VGGHTSPDRR PTINGRYDPA FEVPRNLNGS AQHSEASGMV GMQNSQHLPP
HSQSSMGGGL EGLPLNGYNG LNDSGRPSMP VPELQSLHML HNSHTNPRSP SSILTHHRYN
GGYNDSAYSL MNPQEPNSTS ISHFRLGSST ENPPNSFLGL SPPAQSPGWL PLPSPSPANF
PSFSMASFST TLRYPVLHPV LPHIASIIPQ SLACDLLDVY FTSSSSSHLS PQSPYVVGYI
FRKQSFLHPT KPRVCTPGLL ASMLWVAAQT SDAPFLTSPP SARGRVCQKL LELTIGLLRP
LIHGPAPGET SPNYAANMVI NGVALGGFGV SMDQLGAQSS ATGAVDDVAT YVHLATVISA
SEYKAASMRW WTAAWSLARE LKLGRELPPN TPHARPDAER DGDPDADLSK RHPPPLITSM
GHGPGNTIIN ITEEEREERR RLWWLLYATD RHLALCYNRP LTLLDKECEG LLQPMNDDLW
QAGDFATYRQ AGPPVECTGH SMFGYFLPLM TILGEIVDLQ QARNHPRFGL AFRNSAECEA
QVLEIARQLD VYAQSLKEFE TRYTSSLALG AAETEAAMDG SHPNHVSPSG RSSSTVESRV
NESIVHTKMV VAYGTHIMHV LHILLAGKWD PINLLDDNDL WISSESFVAA MGHAVGAAEA
AAEILEYDPD LSFMPFFFGI YLLQGSFLLL LTADKLQGDA SPSVVRACET IVRAHEACVV
TLNTEYQRTF RKVMRSALAQ VRGRLPEDFG EQQQRRREVL ALYRWTGDGS GLAL
