ID   XLNR_ASPFU              Reviewed;         954 AA.
AC   Q4WZV6;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Xylanolytic transcriptional activator xlnR;
DE   AltName: Full=Xylanase regulator;
GN   Name=xlnR; ORFNames=AFUA_2G15620;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Transcriptional activator of the xylanolytic system. Involved
CC       in the regulation of extracellular cellulolytic and xylanolytic genes
CC       and in the regulation of the intracellular activities of D-xylose
CC       catabolic genes in the pentose catabolic pathway (PCP) in response to
CC       the presence of D-xylose (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the xlnR/xlr1 family. {ECO:0000305}.
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DR   EMBL; AAHF01000001; EAL93859.1; -; Genomic_DNA.
DR   RefSeq; XP_755897.1; XM_750804.1.
DR   AlphaFoldDB; Q4WZV6; -.
DR   STRING; 746128.CADAFUBP00003065; -.
DR   EnsemblFungi; EAL93859; EAL93859; AFUA_2G15620.
DR   GeneID; 3512841; -.
DR   KEGG; afm:AFUA_2G15620; -.
DR   VEuPathDB; FungiDB:Afu2g15620; -.
DR   eggNOG; ENOG502QUI0; Eukaryota.
DR   HOGENOM; CLU_006123_1_0_1; -.
DR   InParanoid; Q4WZV6; -.
DR   OMA; WLVYIVD; -.
DR   OrthoDB; 1430629at2759; -.
DR   Proteomes; UP000002530; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0045493; P:xylan catabolic process; ISS:UniProtKB.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc.
FT   CHAIN           1..954
FT                   /note="Xylanolytic transcriptional activator xlnR"
FT                   /id="PRO_0000393151"
FT   DNA_BIND        119..145
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          51..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          173..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          310..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          566..607
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          758..777
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        572..590
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   954 AA;  103923 MW;  83FE26A7FB9CEF00 CRC64;
     MSTTSLQHFP HSYSPFSSSR SLNRMAQSQT SGLDTLAEGS QYALEQLQMS REAAGSGEAT
     DSVGKPKDQF QVDNDNHHNN HSLSNFKNPS QRDPLVEARS TIRKNSASAP VRRRISRACD
     QCNQLRTKCD GQNPCAHCID FGLTCEYARE RKKRGKASKK DLAAAAAAAA AAATNSGQPN
     GSSGKEDAAL VGGHTSPDRR PTINGRYDPA FEVPRNLNGS AQHSEASGMV GMQNSQHLPP
     HSQSSMGGGL EGLPLNGYNG LNDSGRPSMP VPELQSLHML HNSHTNPRSP SSILPHHRYN
     GGYNDSAYSL MNPQEPNSTS ISHFRLGSST ENPPNSFLGL SPPAQSPGWL PLPSPSPANF
     PSFSMASFST TLRYPVLHPV LPHIASIIPQ SLACDLLDVY FTSSSSSHLS PQSPYVVGYI
     FRKQSFLHPT KPRVCTPGLL ASMLWVAAQT SDAPFLTSPP SARGRVCQKL LELTIGLLRP
     LIHGPAPGET SPNYAANMVI NGVALGGFGV SMDQLGAQSS ATGAVDDVAT YVHLATVISA
     SEYKAASMRW WTAAWSLARE LKLGRELPPN TPHARPDAER DGDPDADLSK RHPPPLITSM
     GHGPGNTIIN ITEEEREERR RLWWLLYATD RHLALCYNRP LTLLDKECEG LLQPMNDDLW
     QAGDFATYRQ AGPPVECTGH SMFGYFLPLM TILGEIVDLQ QARNHPRFGL AFRNSAECEA
     QVLEIARQLD VYAQSLKEFE TRYTSSLALG AAETEAAMDG SHPNHVSPSG RSSSTVESRV
     NESIVHTKMV VAYGTHIMHV LHILLAGKWD PINLLDDNDL WISSESFVAA MGHAVGAAEA
     AAEILEYDPD LSFMPFFFGI YLLQGSFLLL LTADKLQGDA SPSVVRACET IVRAHEACVV
     TLNTEYQRTF RKVMRSALAQ VRGRLPEDFG EQQQRRREVL ALYRWTGDGS GLAL