ID   XLNR_ASPKA              Reviewed;         945 AA.
AC   Q96WP8;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-MAR-2010, sequence version 2.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Xylanolytic transcriptional activator xlnR;
DE   AltName: Full=Xylanase regulator;
GN   Name=xlnR;
OS   Aspergillus kawachii (White koji mold) (Aspergillus awamori var. kawachi).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=1069201;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Iwashita K., Meijia C.E., Ito K.;
RT   "Cloning of XlnR gene from Aspergillus kawachii.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator of the xylanolytic system. Involved
CC       in the regulation of extracellular cellulolytic and xylanolytic genes
CC       and in the regulation of the intracellular activities of D-xylose
CC       catabolic genes in the pentose catabolic pathway (PCP) in response to
CC       the presence of D-xylose (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the xlnR/xlr1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB62022.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB064658; BAB62022.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q96WP8; -.
DR   SMR; Q96WP8; -.
DR   VEuPathDB; FungiDB:AKAW_08587; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0045493; P:xylan catabolic process; ISS:UniProtKB.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..945
FT                   /note="Xylanolytic transcriptional activator xlnR"
FT                   /id="PRO_0000393152"
FT   DNA_BIND        125..151
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          53..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          172..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          559..601
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          751..770
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..196
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        205..251
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        563..581
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   945 AA;  102194 MW;  4175C9D336F19332 CRC64;
     MSTPSIPQFP SPFSPFSSGS QSTGMAPSQT VGLDTLAEGS QYVLEQLQLS RDAAGTGAGD
     GATSTSLRNS MSHAKDQPLF DDERNQSAGS GFKNTLQRDP LVEARSAIRK NSSSAPVRRR
     ISRACDQCNQ LRTKCDGQHP CAHCIEFGLT CEYARERKKR GKASKKDLAA AAAAATHGSN
     GHSGQANASL MAERTSEDSR PAQDVNGRYD STFESHHISS QPSHMQHANN AGISGLHDSQ
     TAPSHSQPSL GTTIDAMHLG HFNTLNDSGR PAMSMSDLRS LPPSVLPPQG LSSGYNASAF
     ALVNPQEPGS PANQFRLGSS AENPTAPFLG LSPPGQSPGW LPLPSPSPAN FPSFSLHPFS
     STLRYPVLQP VLPHIASIIP QSLACDLLDV YFHSSSPSHL SPSSPYVVGY IFRKQSFLHP
     TKPRLCSSGL LASMLWVAAQ TSEAPFLTSP PSARGRVCQK LLELTIGLLR PLVHGPATGE
     ASPNYAANMV INGVALGGFG VSMDQLGAQS SATGAVDDVA TYVHLATVVS ASEYKAASMR
     WWTAAWSLAR ELKLGRELPP NVSHARQDGE RDGDGEADRR HPPTLITSLG HGPGSSGINV
     TEEEREERRR LWWLLYATDR HLALCYNRPL TLLDKECGGL LQPMNDDLWQ VGDFAAAAYR
     QVGPPVECTG HSMYGYFLPL MTILGGIVDL HHAENHPRFG LAFRNSPEWE RQVQDVTRQL
     DTYGRSLKEF EARYTSNLTL GTAENEPAVE GAHLDHTSPS GRSSSTVGSR VSGSIMHTRM
     VVAYGTHIMH VLHILLAGKW DPVNLLEDHD LWISSESFVS AMSHAVGAAE AAAEILEHDP
     DLSFMPFFFG IYLLQGSFLL LLAADKLQGD ASPSVVRACE TIVRAHEACV VTLNTEYQRT
     FRKVMRSALA QVRGRIPEDF GEQQQRRREV LALYRWSGDG SGLAL