XLR5C_MOUSE
ID XLR5C_MOUSE Reviewed; 179 AA.
AC Q9JJR2;
DT 31-JAN-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=X-linked lymphocyte-regulated protein 5C {ECO:0000303|PubMed:26075718};
GN Name=Xlr5c {ECO:0000303|PubMed:26075718, ECO:0000312|MGI:MGI:1350981};
GN Synonyms=Xlr5 {ECO:0000312|MGI:MGI:1350981};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|EMBL:CAB88274.1};
RN [1] {ECO:0000312|EMBL:CAB88274.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129/Sv {ECO:0000312|EMBL:CAB88274.1};
RX PubMed=10854409; DOI=10.1101/gr.10.6.758;
RA Mallon A.-M., Platzer M., Bate R., Gloeckner G., Botcherby M.R.M.,
RA Nordsiek G., Strivens M.A., Kioschis P., Dangel A., Cunningham D.,
RA Straw R.N.A., Weston P., Gilbert M., Fernando S., Goodall K., Hunter G.,
RA Greystrong J.S., Clarke D., Kimberley C., Goerdes M., Blechschmidt K.,
RA Rump A., Hinzmann B., Mundy C.R., Miller W., Poustka A., Herman G.E.,
RA Rhodes M., Denny P., Rosenthal A., Brown S.D.M.;
RT "Comparative genome sequence analysis of the Bpa/Str region in mouse and
RT man.";
RL Genome Res. 10:758-775(2000).
RN [2] {ECO:0000312|EMBL:AL732461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:AAI19510.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=26075718; DOI=10.1371/journal.pone.0130087;
RA Zhuang X.J., Tang W.H., Liu C.Y., Zhu J.L., Feng X., Yan J., Lian Y.,
RA Liu P., Qiao J.;
RT "Identification and characterization of Xlr5c as a novel nuclear
RT localization protein in mouse germ cells.";
RL PLoS ONE 10:E0130087-E0130087(2015).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26075718}. Chromosome
CC {ECO:0000269|PubMed:26075718}. Note=May localize to synaptonemal
CC complexes in meiotic spermatocytes. {ECO:0000269|PubMed:26075718}.
CC -!- TISSUE SPECIFICITY: Expressed in testis (at protein level). Also
CC expressed in ovary. Not detected in other tissues tested.
CC {ECO:0000269|PubMed:26075718}.
CC -!- DEVELOPMENTAL STAGE: Detected in testis from 1 day postpartum (dpp)
CC onwards (at protein level). Expression increases through to 28 dpp and
CC remains high thereafter (at protein level). Highly expressed in
CC spermatocytes at leptotene and pachytene stages of meiosis.
CC {ECO:0000269|PubMed:26075718}.
CC -!- SIMILARITY: Belongs to the XLR/SYCP3 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL049866; CAB88274.1; -; Genomic_DNA.
DR EMBL; AL732461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC119509; AAI19510.1; -; mRNA.
DR CCDS; CCDS30198.1; -.
DR RefSeq; NP_113681.1; NM_031493.1.
DR AlphaFoldDB; Q9JJR2; -.
DR SMR; Q9JJR2; -.
DR STRING; 10090.ENSMUSP00000110147; -.
DR iPTMnet; Q9JJR2; -.
DR PhosphoSitePlus; Q9JJR2; -.
DR PaxDb; Q9JJR2; -.
DR PRIDE; Q9JJR2; -.
DR DNASU; 27084; -.
DR Ensembl; ENSMUST00000088450; ENSMUSP00000085796; ENSMUSG00000067764.
DR GeneID; 27084; -.
DR KEGG; mmu:27084; -.
DR UCSC; uc009tlo.1; mouse.
DR CTD; 27084; -.
DR MGI; MGI:1350981; Xlr5c.
DR VEuPathDB; HostDB:ENSMUSG00000067764; -.
DR GeneTree; ENSGT00390000000062; -.
DR BioGRID-ORCS; 27084; 3 hits in 20 CRISPR screens.
DR PRO; PR:Q9JJR2; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9JJR2; protein.
DR Bgee; ENSMUSG00000067764; Expressed in animal zygote and 16 other tissues.
DR ExpressionAtlas; Q9JJR2; baseline and differential.
DR GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0000795; C:synaptonemal complex; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0007286; P:spermatid development; IBA:GO_Central.
DR InterPro; IPR006888; XLR/SYCP3/FAM9_dom.
DR Pfam; PF04803; Cor1; 1.
PE 1: Evidence at protein level;
KW Chromosome; Coiled coil; Nucleus; Reference proteome.
FT CHAIN 1..179
FT /note="X-linked lymphocyte-regulated protein 5C"
FT /id="PRO_0000443090"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 146..175
FT /evidence="ECO:0000255"
FT COMPBIAS 1..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 179 AA; 20702 MW; 46BECB54FAE0A4F3 CRC64;
MSNKEQKDMK KSGKHQRVHK TLPSDDFKNS DAVNPADKPA VGTSGMGSHS SGSDMQEARE
PVQKKMQDFK GDDGTGLLME KRKQFEEDVN ASFRSLNENL QSILKAQQNS RQELKSLYCE
RFGSVYHNWL VEMDRTRDQE EYFSFITQQQ MKILQTAIED HETKLKNAKD MCDTFLKVW