XNDC1_HUMAN
ID XNDC1_HUMAN Reviewed; 234 AA.
AC Q6ZNB5;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-FEB-2022, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Protein XNDC1N {ECO:0000305};
DE AltName: Full=XRCC1 N-terminal domain-containing 1 N-terminal like {ECO:0000312|HGNC:HGNC:54661};
GN Name=XNDC1N {ECO:0000312|HGNC:HGNC:54661};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6ZNB5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZNB5-2; Sequence=VSP_061370, VSP_061371;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK131288; BAD18460.1; -; mRNA.
DR EMBL; AP000719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AP002495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; Q6ZNB5; -.
DR SMR; Q6ZNB5; -.
DR STRING; 9606.ENSP00000434508; -.
DR ChEMBL; CHEMBL3721310; -.
DR iPTMnet; Q6ZNB5; -.
DR PhosphoSitePlus; Q6ZNB5; -.
DR BioMuta; -; -.
DR MassIVE; Q6ZNB5; -.
DR PaxDb; Q6ZNB5; -.
DR PRIDE; Q6ZNB5; -.
DR Antibodypedia; 66219; 2 antibodies from 1 providers.
DR MANE-Select; ENST00000679412.2; ENSP00000506430.1; NM_001375847.2; NP_001362776.1.
DR UCSC; uc001oqz.3; human. [Q6ZNB5-1]
DR HGNC; HGNC:54661; XNDC1N.
DR HPA; ENSG00000254469; Low tissue specificity.
DR neXtProt; NX_Q6ZNB5; -.
DR OpenTargets; ENSG00000254469; -.
DR VEuPathDB; HostDB:ENSG00000254469; -.
DR eggNOG; ENOG502RXNH; Eukaryota.
DR GeneTree; ENSGT00390000004140; -.
DR HOGENOM; CLU_2043292_0_0_1; -.
DR OMA; DWGGWII; -.
DR PhylomeDB; Q6ZNB5; -.
DR PathwayCommons; Q6ZNB5; -.
DR Pharos; Q6ZNB5; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q6ZNB5; protein.
DR ExpressionAtlas; Q6ZNB5; baseline and differential.
DR GO; GO:0005694; C:chromosome; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0000012; P:single strand break repair; IEA:InterPro.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR002706; Xrcc1_N.
DR Pfam; PF01834; XRCC1_N; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..234
FT /note="Protein XNDC1N"
FT /id="PRO_0000342286"
FT VAR_SEQ 115..142
FT /note="VDFLAPASGELWDRLRLTCSRPFTRHQS -> GKEGKSRKDGGGLYEKQRCS
FT TKEDCECY (in isoform 2)"
FT /id="VSP_061370"
FT VAR_SEQ 143..234
FT /note="Missing (in isoform 2)"
FT /id="VSP_061371"
SQ SEQUENCE 234 AA; 25996 MW; 5A2AAB72623B873A CRC64;
MAPVKISHVV SFSSQDPKYP VENLLNPDSP RRPWLGCPQD KSGQLKVELQ LERAVPTGYI
DVGNCGCAFL QIDVGHSSWP LDRPFITLLP ATTLMSLTDS KQGKNRSGVR MFKDVDFLAP
ASGELWDRLR LTCSRPFTRH QSFGLAFLRV CSSLDSLDDS VVGPSALLSS VLNKIREFKT
CFFSWSLKKM ELEFSPLLLS INLNDLQFAA DAEVSTVSNC MFISIALQSA MIIF
