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XNDC1_HUMAN
ID   XNDC1_HUMAN             Reviewed;         234 AA.
AC   Q6ZNB5;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Protein XNDC1N {ECO:0000305};
DE   AltName: Full=XRCC1 N-terminal domain-containing 1 N-terminal like {ECO:0000312|HGNC:HGNC:54661};
GN   Name=XNDC1N {ECO:0000312|HGNC:HGNC:54661};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6ZNB5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6ZNB5-2; Sequence=VSP_061370, VSP_061371;
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DR   EMBL; AK131288; BAD18460.1; -; mRNA.
DR   EMBL; AP000719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP002490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP002495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q6ZNB5; -.
DR   SMR; Q6ZNB5; -.
DR   STRING; 9606.ENSP00000434508; -.
DR   ChEMBL; CHEMBL3721310; -.
DR   iPTMnet; Q6ZNB5; -.
DR   PhosphoSitePlus; Q6ZNB5; -.
DR   BioMuta; -; -.
DR   MassIVE; Q6ZNB5; -.
DR   PaxDb; Q6ZNB5; -.
DR   PRIDE; Q6ZNB5; -.
DR   Antibodypedia; 66219; 2 antibodies from 1 providers.
DR   MANE-Select; ENST00000679412.2; ENSP00000506430.1; NM_001375847.2; NP_001362776.1.
DR   UCSC; uc001oqz.3; human. [Q6ZNB5-1]
DR   HGNC; HGNC:54661; XNDC1N.
DR   HPA; ENSG00000254469; Low tissue specificity.
DR   neXtProt; NX_Q6ZNB5; -.
DR   OpenTargets; ENSG00000254469; -.
DR   VEuPathDB; HostDB:ENSG00000254469; -.
DR   eggNOG; ENOG502RXNH; Eukaryota.
DR   GeneTree; ENSGT00390000004140; -.
DR   HOGENOM; CLU_2043292_0_0_1; -.
DR   OMA; DWGGWII; -.
DR   PhylomeDB; Q6ZNB5; -.
DR   PathwayCommons; Q6ZNB5; -.
DR   Pharos; Q6ZNB5; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q6ZNB5; protein.
DR   ExpressionAtlas; Q6ZNB5; baseline and differential.
DR   GO; GO:0005694; C:chromosome; IDA:HPA.
DR   GO; GO:0005730; C:nucleolus; IDA:HPA.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0000012; P:single strand break repair; IEA:InterPro.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR002706; Xrcc1_N.
DR   Pfam; PF01834; XRCC1_N; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..234
FT                   /note="Protein XNDC1N"
FT                   /id="PRO_0000342286"
FT   VAR_SEQ         115..142
FT                   /note="VDFLAPASGELWDRLRLTCSRPFTRHQS -> GKEGKSRKDGGGLYEKQRCS
FT                   TKEDCECY (in isoform 2)"
FT                   /id="VSP_061370"
FT   VAR_SEQ         143..234
FT                   /note="Missing (in isoform 2)"
FT                   /id="VSP_061371"
SQ   SEQUENCE   234 AA;  25996 MW;  5A2AAB72623B873A CRC64;
     MAPVKISHVV SFSSQDPKYP VENLLNPDSP RRPWLGCPQD KSGQLKVELQ LERAVPTGYI
     DVGNCGCAFL QIDVGHSSWP LDRPFITLLP ATTLMSLTDS KQGKNRSGVR MFKDVDFLAP
     ASGELWDRLR LTCSRPFTRH QSFGLAFLRV CSSLDSLDDS VVGPSALLSS VLNKIREFKT
     CFFSWSLKKM ELEFSPLLLS INLNDLQFAA DAEVSTVSNC MFISIALQSA MIIF
 
 
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