ID   XNIF_XENLA              Reviewed;         470 AA.
AC   P35617;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Low molecular weight neuronal intermediate filament;
DE   AltName: Full=XNIF;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 453-463.
RC   TISSUE=Brain;
RX   PubMed=1494944; DOI=10.1523/jneurosci.12-08-03010.1992;
RA   Charnas L.R., Szaro B.G., Gainer H.;
RT   "Identification and developmental expression of a novel low molecular
RT   weight neuronal intermediate filament protein expressed in Xenopus
RT   laevis.";
RL   J. Neurosci. 12:3010-3024(1992).
CC   -!- TISSUE SPECIFICITY: Nervous system; in axons in the PNS and in small
CC       perikarya in the dorsal root ganglion.
CC   -!- DEVELOPMENTAL STAGE: Expressed in axons of early differentiating
CC       neurons as well as in the adult nervous system.
CC   -!- DOMAIN: This protein contains a central IF rod domain characteristic of
CC       IF proteins but displays divergent head and tail domains.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01188}.
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DR   EMBL; M86653; AAA83019.1; -; mRNA.
DR   PIR; A44841; A44841.
DR   AlphaFoldDB; P35617; -.
DR   SMR; P35617; -.
DR   PRIDE; P35617; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005882; C:intermediate filament; IDA:CACAO.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR006821; Intermed_filament_DNA-bd.
DR   InterPro; IPR002957; Keratin_I.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF04732; Filament_head; 1.
DR   PRINTS; PR01248; TYPE1KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Direct protein sequencing; Intermediate filament;
KW   Reference proteome.
FT   CHAIN           1..470
FT                   /note="Low molecular weight neuronal intermediate filament"
FT                   /id="PRO_0000063860"
FT   DOMAIN          88..399
FT                   /note="IF rod"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT   REGION          1..91
FT                   /note="Head"
FT   REGION          91..123
FT                   /note="Coil 1A"
FT   REGION          121..136
FT                   /note="Linker 1"
FT   REGION          137..232
FT                   /note="Coil 1B"
FT   REGION          233..251
FT                   /note="Linker 12"
FT   REGION          252..270
FT                   /note="Coil 2A"
FT   REGION          271..279
FT                   /note="Linker 2"
FT   REGION          280..395
FT                   /note="Coil 2B"
FT   REGION          396..470
FT                   /note="Tail"
FT   REGION          414..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   470 AA;  53672 MW;  CB462E2E6BEAC41C CRC64;
     MTSRELYTSS YKKIFGDWGR SSSLLYTTNS SSSTRSQSYR PREAYTSNIS SYRKVSRSPG
     HLSSAQDHFD LSQSTALSNE LKIVRTNEKE QLQGLNDRFV TYIEKVHHLE QQNKLLESEV
     TLLRQKHSEP SRLSHIYEQE IRELRSKLEE QEQDKDQAQL DYEHLGACLE QLKLKLEQES
     ARREEAEDVM KNYRKDLDQA TLNRLQLEKK VESLLDEIAF LRKVHEEEIA ELQASVQEAQ
     ISVEMDVVSK PDLTAALKEI RMQYEVLSAR NQQSSEEWYQ AKIANVSLEA SRNNDSVRQA
     KEEITEYRRQ LQARTLEIDA LRSANESLER QLQEAEDRSN EEMSHLQDTI GQLDNALRTT
     KEEMARHLRE YQDLLNVKMA LDIEIAAYRK LLEGEETRLT SVGGGSMFGI GYPFSSGSYS
     GGRSSTTSTI SIRKEEKKES PEGGKGGSSG QPKTSKPGDQ EKISQKAAAN