ID   CAP4C_STRPN             Reviewed;         299 AA.
AC   P58313;
DT   18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
DT   18-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase;
DE            EC=2.7.7.9;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase;
DE   AltName: Full=UDP-glucose pyrophosphorylase;
DE            Short=UDPGP;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase;
GN   Name=cap4C; OrderedLocusNames=SP_2092;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC         alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC         ChEBI:CHEBI:58885; EC=2.7.7.9;
CC   -!- PATHWAY: Carbohydrate metabolism; nucleotide-sugar metabolism.
CC   -!- PATHWAY: Capsule biogenesis; capsule polysaccharide biosynthesis.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family. {ECO:0000305}.
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DR   EMBL; AE005672; AAK76151.1; -; Genomic_DNA.
DR   PIR; F95244; F95244.
DR   RefSeq; WP_000202234.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P58313; -.
DR   SMR; P58313; -.
DR   STRING; 170187.SP_2092; -.
DR   EnsemblBacteria; AAK76151; AAK76151; SP_2092.
DR   KEGG; spn:SP_2092; -.
DR   eggNOG; COG1210; Bacteria.
DR   OMA; MHYVRQG; -.
DR   PhylomeDB; P58313; -.
DR   BioCyc; SPNE170187:G1FZB-2177-MON; -.
DR   UniPathway; UPA00215; -.
DR   UniPathway; UPA00934; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   CDD; cd02541; UGPase_prokaryotic; 1.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR43197; PTHR43197; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
DR   TIGRFAMs; TIGR01099; galU; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Exopolysaccharide synthesis;
KW   Nucleotidyltransferase; Transferase.
FT   CHAIN           1..299
FT                   /note="UTP--glucose-1-phosphate uridylyltransferase"
FT                   /id="PRO_0000201366"
SQ   SEQUENCE   299 AA;  33278 MW;  E9D644167B4356C3 CRC64;
     MTSKVRKAVI PAAGLGTRFL PATKALAKEM LPIVDKPTIQ FIVEEALKSG IEDILVVTGK
     SKRSIEDHFD SNFELEYNLK EKGKTDLLKL VDKTTDMRLH FIRQTHPRGL GDAVLQAKAF
     VGNEPFVVML GDDLMDITDE KAVPLTKQLM DDYERTHAST IAVMPVPHDE VSAYGVIAPQ
     GEGKDGLYSV ETFVEKPAPE DAPSDLAIIG RYLLTPEIFE ILEKQAPGAG NEIQLTDAID
     TLNKTQRVFA REFKGARYDV GDKFGFMKTS IDYALKHPQV KDDLKNYLIQ LGKELTEKE