ID   XP1_XENLA               Reviewed;          78 AA.
AC   Q00222;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Putative gastrointestinal growth factor xP1;
DE   Flags: Precursor;
GN   Name=p1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Stomach;
RX   PubMed=1939167; DOI=10.1016/s0021-9258(18)54856-0;
RA   Hauser F., Hoffmann W.;
RT   "xP1 and xP4. P-domain peptides expressed in Xenopus laevis stomach
RT   mucosa.";
RL   J. Biol. Chem. 266:21306-21309(1991).
CC   -!- FUNCTION: May act as a growth factor.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Stomach mucosa.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M75033; AAA50000.1; ALT_SEQ; mRNA.
DR   PIR; A40850; A40850.
DR   RefSeq; NP_001079242.1; NM_001085773.1.
DR   AlphaFoldDB; Q00222; -.
DR   SMR; Q00222; -.
DR   GeneID; 378509; -.
DR   KEGG; xla:378509; -.
DR   CTD; 378509; -.
DR   Xenbase; XB-GENE-6252667; tff3.1.S.
DR   OrthoDB; 1563185at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 378509; Expressed in stomach and 9 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd00111; Trefoil; 1.
DR   Gene3D; 4.10.110.10; -; 1.
DR   InterPro; IPR017994; P_trefoil_chordata.
DR   InterPro; IPR017957; P_trefoil_CS.
DR   InterPro; IPR000519; P_trefoil_dom.
DR   InterPro; IPR044913; P_trefoil_dom_sf.
DR   PANTHER; PTHR13826; PTHR13826; 1.
DR   Pfam; PF00088; Trefoil; 1.
DR   PRINTS; PR00680; PTREFOIL.
DR   SMART; SM00018; PD; 1.
DR   SUPFAM; SSF57492; SSF57492; 1.
DR   PROSITE; PS00025; P_TREFOIL_1; 1.
DR   PROSITE; PS51448; P_TREFOIL_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..78
FT                   /note="Putative gastrointestinal growth factor xP1"
FT                   /id="PRO_0000023469"
FT   DOMAIN          30..73
FT                   /note="P-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        32..58
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        42..57
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        52..69
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
SQ   SEQUENCE   78 AA;  8524 MW;  607737575C9E56E6 CRC64;
     MNYKVFCLVA IALIVGSIGS ANGQAAFTEE QCSVERLARV NCGYSGITPQ ECTKQGCCFD
     STIQDAPWCF YPRATPEY