ID   XP4_XENLA               Reviewed;         224 AA.
AC   Q00223;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Putative gastrointestinal growth factor xP4;
DE   AltName: Full=TFF p4.1;
DE   Flags: Precursor;
GN   Name=p4;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Stomach;
RX   PubMed=1939167; DOI=10.1016/s0021-9258(18)54856-0;
RA   Hauser F., Hoffmann W.;
RT   "xP1 and xP4. P-domain peptides expressed in Xenopus laevis stomach
RT   mucosa.";
RL   J. Biol. Chem. 266:21306-21309(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10673035; DOI=10.1016/s0167-4781(99)00185-2;
RA   Botzler C., Oertel M., Hinz M., Hoffmann W.;
RT   "Structure of the Xenopus laevis TFF-gene xP4.1, differentially expressed
RT   to its duplicated homolog xP4.2.";
RL   Biochim. Biophys. Acta 1489:345-353(1999).
CC   -!- FUNCTION: May act as a growth factor.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Stomach mucosa.
CC   -!- PTM: Glycosylated.
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DR   EMBL; M75034; AAA50003.1; -; mRNA.
DR   EMBL; AJ249172; CAB65600.1; -; Genomic_DNA.
DR   EMBL; AJ249175; CAB65600.1; JOINED; Genomic_DNA.
DR   EMBL; AJ249176; CAB65600.1; JOINED; Genomic_DNA.
DR   EMBL; AJ249177; CAB65600.1; JOINED; Genomic_DNA.
DR   PIR; B40850; B40850.
DR   RefSeq; NP_001079243.1; NM_001085774.1.
DR   AlphaFoldDB; Q00223; -.
DR   SMR; Q00223; -.
DR   GeneID; 378510; -.
DR   KEGG; xla:378510; -.
DR   CTD; 378510; -.
DR   Xenbase; XB-GENE-5824171; tff3.8.S.
DR   OMA; CFNDTIP; -.
DR   OrthoDB; 1563185at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 378510; Expressed in stomach and 10 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   CDD; cd00111; Trefoil; 4.
DR   Gene3D; 4.10.110.10; -; 4.
DR   InterPro; IPR017994; P_trefoil_chordata.
DR   InterPro; IPR017957; P_trefoil_CS.
DR   InterPro; IPR000519; P_trefoil_dom.
DR   InterPro; IPR044913; P_trefoil_dom_sf.
DR   PANTHER; PTHR13826; PTHR13826; 4.
DR   Pfam; PF00088; Trefoil; 4.
DR   PRINTS; PR00680; PTREFOIL.
DR   SMART; SM00018; PD; 4.
DR   SUPFAM; SSF57492; SSF57492; 4.
DR   PROSITE; PS00025; P_TREFOIL_1; 4.
DR   PROSITE; PS51448; P_TREFOIL_2; 4.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Growth factor; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..224
FT                   /note="Putative gastrointestinal growth factor xP4"
FT                   /id="PRO_0000023471"
FT   DOMAIN          25..68
FT                   /note="P-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DOMAIN          73..117
FT                   /note="P-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DOMAIN          123..167
FT                   /note="P-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DOMAIN          173..216
FT                   /note="P-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        27..53
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        37..52
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        47..64
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        75..102
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        86..101
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        96..113
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        125..152
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        136..151
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        146..163
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        175..201
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        185..200
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
FT   DISULFID        195..212
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00779"
SQ   SEQUENCE   224 AA;  24815 MW;  6AE05B3429EFC635 CRC64;
     MANSVFWAIA VALVLGAEAY MPLDYRCGVK PKSRDNCGPP GISPDECVKK GCCFDDSDPD
     SIWCYTPWKF EDTICNPAEP KARVNCGYPG ITSQDCDKKG CCFNDTIPNV VWCYQPIIEA
     VERDCSAVEP KKRVNCGPPG VSPDECIKNG CCFNSDVGGV PWCFKPEIKK ELLQCAVLPK
     ARINCGYPDI TMDQCYKKGC CYDSSESDSI WCFYPDIEDV TIIE