ID   XPA_CHICK               Reviewed;         267 AA.
AC   P27089;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=DNA repair protein complementing XP-A cells homolog;
DE   AltName: Full=Xeroderma pigmentosum group A-complementing protein homolog;
GN   Name=XPA; Synonyms=XPAC;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1764072; DOI=10.1016/0006-291x(91)92070-z;
RA   Shimamoto T., Kohno K., Tanaka K., Okada Y.;
RT   "Molecular cloning of human XPAC gene homologs from chicken, Xenopus laevis
RT   and Drosophila melanogaster.";
RL   Biochem. Biophys. Res. Commun. 181:1231-1237(1991).
CC   -!- FUNCTION: Involved in DNA excision repair. Initiates repair by binding
CC       to damaged sites with various affinities, depending on the photoproduct
CC       and the transcriptional state of the region (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the XPA family. {ECO:0000305}.
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DR   EMBL; D31896; BAA06694.1; -; mRNA.
DR   PIR; JQ1323; JQ1323.
DR   AlphaFoldDB; P27089; -.
DR   SMR; P27089; -.
DR   STRING; 9031.ENSGALP00000042402; -.
DR   PaxDb; P27089; -.
DR   VEuPathDB; HostDB:geneid_395659; -.
DR   eggNOG; KOG4017; Eukaryota.
DR   InParanoid; P27089; -.
DR   PhylomeDB; P27089; -.
DR   Reactome; R-GGA-353303; Nucleotide Excision Repair.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR   GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   Gene3D; 3.90.530.10; -; 1.
DR   InterPro; IPR009061; DNA-bd_dom_put_sf.
DR   InterPro; IPR000465; XPA.
DR   InterPro; IPR022656; XPA_C.
DR   InterPro; IPR022658; XPA_CS.
DR   InterPro; IPR037129; XPA_sf.
DR   InterPro; IPR022652; Znf_XPA_CS.
DR   PANTHER; PTHR10142; PTHR10142; 1.
DR   Pfam; PF05181; XPA_C; 1.
DR   Pfam; PF01286; XPA_N; 1.
DR   SUPFAM; SSF46955; SSF46955; 1.
DR   TIGRFAMs; TIGR00598; rad14; 1.
DR   PROSITE; PS00752; XPA_1; 1.
DR   PROSITE; PS00753; XPA_2; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..267
FT                   /note="DNA repair protein complementing XP-A cells homolog"
FT                   /id="PRO_0000208650"
FT   ZN_FING         99..123
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          46..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           25..46
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   267 AA;  30978 MW;  70035FD258BA53AB CRC64;
     MGRAAPGPDE GAEGERPSIS ATALARMERN RRRALALRQA RLAARPYPQA AAGAGPPQGR
     DTGGGFFLEE EEEEEEQRRA AERIVHPPAP VLQFDYLICG DCGKEFMDSY LMQHFDWATC
     DNCRDAEDKH KLITRTEAKE EYLLKDCDLD KREPVLRFIV KKNPHNPRWG DMKLYLKLQV
     IKRALEVWGN EESLQEAKEQ RRDSREKMKQ KRFDKKVKEL RRAVRSSLWK KTASIHEHEY
     GPEENVDEET YKKTCTVCGH ELTYEKM