ID   CAP5A_STAAE             Reviewed;         222 AA.
AC   P95695; A6QDD5;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Capsular polysaccharide type 5 biosynthesis protein cap5A;
GN   Name=cap5A; OrderedLocusNames=NWMN_0095;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=9245821; DOI=10.1099/00221287-143-7-2395;
RA   Sau S., Bhasin N., Wann E.R., Lee J.C., Foster T.J., Lee C.Y.;
RT   "The Staphylococcus aureus allelic genetic loci for serotype 5 and 8
RT   capsule expression contain the type-specific genes flanked by common
RT   genes.";
RL   Microbiology 143:2395-2405(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
CC   -!- FUNCTION: Required for the biosynthesis of type 5 capsular
CC       polysaccharide (Cap5/CP5). Might act as the chain-length regulator.
CC       {ECO:0000269|PubMed:9245821}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CpsC/CapA family. {ECO:0000305}.
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DR   EMBL; U81973; AAC46084.1; -; Genomic_DNA.
DR   EMBL; AP009351; BAF66367.1; -; Genomic_DNA.
DR   PIR; A89776; A89776.
DR   RefSeq; WP_000446299.1; NZ_CP023390.1.
DR   AlphaFoldDB; P95695; -.
DR   SMR; P95695; -.
DR   EnsemblBacteria; BAF66367; BAF66367; NWMN_0095.
DR   KEGG; sae:NWMN_0095; -.
DR   HOGENOM; CLU_082668_1_1_9; -.
DR   OMA; TNTYKVI; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR   GO; GO:0015774; P:polysaccharide transport; IEA:InterPro.
DR   InterPro; IPR003856; LPS_length_determ_N_term.
DR   InterPro; IPR005701; MPA1-like.
DR   Pfam; PF02706; Wzz; 1.
DR   TIGRFAMs; TIGR01006; polys_exp_MPA1; 1.
PE   3: Inferred from homology;
KW   Capsule biogenesis/degradation; Cell membrane; Exopolysaccharide synthesis;
KW   Membrane; Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..222
FT                   /note="Capsular polysaccharide type 5 biosynthesis protein
FT                   cap5A"
FT                   /id="PRO_0000217224"
FT   TRANSMEM        20..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   222 AA;  24854 MW;  B6126E248D0112BA CRC64;
     MESTLELTKI KEVLQKNLKI LIILPLLFLI ISAIVTFFVL SPKYQANTQI LVNQTKGDNP
     QFMAQEVQSN IQLVNTYKEI VKSPRILDEV SKDLNDKYSP SKLSSMLTIT NQENTQLINI
     QVKSGHKQDS EKIANSFAKV TSKQIPKIMS VDNVSILSKA DGTAVKVAPK TVVNLIGAFF
     LGLVVALIYI FFKVIFDKRI KDEEDVEKEL GLPVLGSIQK FN