XPD_THEAC
ID XPD_THEAC Reviewed; 602 AA.
AC Q9HM14;
DT 14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=ATP-dependent DNA helicase Ta0057;
DE EC=3.6.4.12;
GN OrderedLocusNames=Ta0057;
OS Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS 15155 / AMRC-C165).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC Thermoplasmataceae; Thermoplasma.
OX NCBI_TaxID=273075;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX PubMed=11029001; DOI=10.1038/35035069;
RA Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT acidophilum.";
RL Nature 407:508-513(2000).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS), AND IRON-SULFUR CLUSTER.
RX PubMed=18578568; DOI=10.1371/journal.pbio.0060149;
RA Wolski S.C., Kuper J., Hanzelmann P., Truglio J.J., Croteau D.L.,
RA Van Houten B., Kisker C.;
RT "Crystal structure of the FeS cluster-containing nucleotide excision repair
RT helicase XPD.";
RL PLoS Biol. 6:E149-E149(2008).
CC -!- FUNCTION: ATP-dependent 5'-3' DNA helicase involved in nucleotide
CC excision repair (NER) of DNA. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Note=Binds 1 [4Fe-4S] cluster.;
CC -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAC11205.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AL445063; CAC11205.1; ALT_INIT; Genomic_DNA.
DR PDB; 2VSF; X-ray; 2.90 A; A=1-602.
DR PDB; 4A15; X-ray; 2.20 A; A=2-602.
DR PDB; 5H8W; X-ray; 2.20 A; A=1-597.
DR PDBsum; 2VSF; -.
DR PDBsum; 4A15; -.
DR PDBsum; 5H8W; -.
DR AlphaFoldDB; Q9HM14; -.
DR SMR; Q9HM14; -.
DR STRING; 273075.Ta0057m; -.
DR EnsemblBacteria; CAC11205; CAC11205; CAC11205.
DR KEGG; tac:Ta0057; -.
DR eggNOG; arCOG00770; Archaea.
DR HOGENOM; CLU_006515_9_0_2; -.
DR OMA; IREQFFR; -.
DR BRENDA; 3.6.4.12; 6324.
DR EvolutionaryTrace; Q9HM14; -.
DR Proteomes; UP000001024; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 1.10.30.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR010614; DEAD_2.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR010643; HBB.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR042493; XPD_DNA_FeS.
DR PANTHER; PTHR11472; PTHR11472; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF06777; HBB; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 1: Evidence at protein level;
KW 3D-structure; 4Fe-4S; ATP-binding; DNA damage; DNA repair; DNA-binding;
KW Helicase; Hydrolase; Iron; Iron-sulfur; Metal-binding; Nucleotide-binding;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..602
FT /note="ATP-dependent DNA helicase Ta0057"
FT /id="PRO_0000352310"
FT DOMAIN 1..247
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 421..602
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT MOTIF 193..196
FT /note="DEAH box"
FT BINDING 11..18
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT BINDING 74
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT BINDING 95
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT BINDING 110
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT BINDING 146
FT /ligand="[4Fe-4S] cluster"
FT /ligand_id="ChEBI:CHEBI:49883"
FT STRAND 4..10
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 13..16
FT /evidence="ECO:0007829|PDB:2VSF"
FT HELIX 17..32
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 35..42
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 43..59
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 64..66
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 70..73
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 77..80
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 88..103
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 107..109
FT /evidence="ECO:0007829|PDB:2VSF"
FT HELIX 115..118
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 120..129
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 133..142
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 147..154
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 155..157
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 159..164
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 165..168
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 171..181
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 185..187
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 188..192
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 195..197
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 198..206
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 208..211
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 212..224
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 229..231
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 236..254
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 256..258
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 260..262
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 265..275
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 279..302
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 310..322
FT /evidence="ECO:0007829|PDB:4A15"
FT TURN 326..328
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 329..334
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 336..338
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 340..345
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 349..352
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 353..357
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 358..366
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 370..377
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 383..385
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 392..394
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 395..400
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 407..409
FT /evidence="ECO:0007829|PDB:5H8W"
FT HELIX 412..429
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 433..438
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 440..446
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 464..473
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 479..483
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 489..491
FT /evidence="ECO:0007829|PDB:5H8W"
FT HELIX 496..498
FT /evidence="ECO:0007829|PDB:5H8W"
FT STRAND 501..506
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 514..527
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 530..534
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 536..548
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 553..555
FT /evidence="ECO:0007829|PDB:2VSF"
FT STRAND 558..563
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 565..573
FT /evidence="ECO:0007829|PDB:4A15"
FT STRAND 578..581
FT /evidence="ECO:0007829|PDB:4A15"
FT HELIX 583..595
FT /evidence="ECO:0007829|PDB:4A15"
SQ SEQUENCE 602 AA; 69169 MW; CE13FA7D1F3A0DD8 CRC64;
MQKSYGVALE SPTGSGKTIM ALKSALQYSS ERKLKVLYLV RTNSQEEQVI KELRSLSSTM
KIRAIPMQGR VNMCILYRMV DDLHEINAES LAKFCNMKKR EVMAGNEAAC PYFNFKIRSD
ETKRFLFDEL PTAEEFYDYG ERNNVCPYES MKAALPDADI VIAPYAYFLN RSVAEKFLSH
WGVSRNQIVI ILDEAHNLPD IGRSIGSFRI SVESLNRADR EAQAYGDPEL SQKIHVSDLI
EMIRSALQSM VSERCGKGDV RIRFQEFMEY MRIMNKRSER EIRSLLNYLY LFGEYVENEK
EKVGKVPFSY CSSVASRIIA FSDQDEEKYA AILSPEDGGY MQAACLDPSG ILEVLKESKT
IHMSGTLDPF DFYSDITGFE IPFKKIGEIF PPENRYIAYY DGVSSKYDTL DEKELDRMAT
VIEDIILKVK KNTIVYFPSY SLMDRVENRV SFEHMKEYRG IDQKELYSML KKFRRDHGTI
FAVSGGRLSE GINFPGNELE MIILAGLPFP RPDAINRSLF DYYERKYGKG WEYSVVYPTA
IKIRQEIGRL IRSAEDTGAC VILDKRAGQF RKFIPDMKKT SDPASDIYNF FISAQAREKY
GA
