ID   XPO1_DICDI              Reviewed;        1057 AA.
AC   Q54EV7;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Exportin-1;
DE            Short=Exp1;
GN   Name=xpo1; Synonyms=crm1; ORFNames=DDB_G0291306;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Mediates the nuclear export of cellular proteins (cargos)
CC       bearing a leucine-rich nuclear export signal (NES).
CC   -!- SUBUNIT: Component of a nuclear export receptor complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, perinuclear
CC       region {ECO:0000250}. Note=Shuttles between the nucleus and the
CC       cytoplasm. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the exportin family. {ECO:0000305}.
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DR   EMBL; AAFI02000177; EAL61637.2; -; Genomic_DNA.
DR   RefSeq; XP_635133.2; XM_630041.2.
DR   AlphaFoldDB; Q54EV7; -.
DR   SMR; Q54EV7; -.
DR   STRING; 44689.DDB0234066; -.
DR   PaxDb; Q54EV7; -.
DR   EnsemblProtists; EAL61637; EAL61637; DDB_G0291306.
DR   GeneID; 8628079; -.
DR   KEGG; ddi:DDB_G0291306; -.
DR   dictyBase; DDB_G0291306; xpo1.
DR   eggNOG; KOG2020; Eukaryota.
DR   HOGENOM; CLU_011906_0_0_1; -.
DR   InParanoid; Q54EV7; -.
DR   OMA; HNINTLC; -.
DR   PhylomeDB; Q54EV7; -.
DR   Reactome; R-DDI-5687128; MAPK6/MAPK4 signaling.
DR   PRO; PR:Q54EV7; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:dictyBase.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; ISS:dictyBase.
DR   GO; GO:0000055; P:ribosomal large subunit export from nucleus; IBA:GO_Central.
DR   GO; GO:0000056; P:ribosomal small subunit export from nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR041123; CRM1_repeat.
DR   InterPro; IPR041235; Exp1_repeat_2.
DR   InterPro; IPR013598; Exportin-1/Importin-b-like.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR045065; XPO1/5.
DR   InterPro; IPR014877; XPO1_C_dom.
DR   InterPro; IPR040485; XPO1_repeat_3.
DR   PANTHER; PTHR11223; PTHR11223; 1.
DR   Pfam; PF08767; CRM1_C; 1.
DR   Pfam; PF18777; CRM1_repeat; 1.
DR   Pfam; PF18784; CRM1_repeat_2; 1.
DR   Pfam; PF18787; CRM1_repeat_3; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   Pfam; PF08389; Xpo1; 1.
DR   SMART; SM01102; CRM1_C; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Repeat;
KW   Translocation; Transport.
FT   CHAIN           1..1057
FT                   /note="Exportin-1"
FT                   /id="PRO_0000328479"
FT   DOMAIN          36..102
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
FT   REPEAT          239..275
FT                   /note="HEAT 1"
FT   REPEAT          281..321
FT                   /note="HEAT 2"
FT   REPEAT          462..501
FT                   /note="HEAT 3"
FT   REPEAT          506..544
FT                   /note="HEAT 4"
FT   REPEAT          551..588
FT                   /note="HEAT 5"
FT   REPEAT          596..633
FT                   /note="HEAT 6"
FT   REPEAT          739..776
FT                   /note="HEAT 7"
FT   REPEAT          781..818
FT                   /note="HEAT 8"
FT   REPEAT          855..892
FT                   /note="HEAT 9"
FT   REPEAT          902..925
FT                   /note="HEAT 10"
FT   REPEAT          926..965
FT                   /note="HEAT 11"
SQ   SEQUENCE   1057 AA;  122014 MW;  2B9B86C8BDF82C69 CRC64;
     MENILNFNEP LDINLLDQIV SVLYNPLSNK NDIKAAQMVL GKFQEHPDAW SKVDTILETS
     KIVQTKFIAL VIMDSLIKYR WKSLPREQCE GIKNYIVSLI IRLSSDPQTS SREKLLVNKL
     NLVFVQILKQ EWTTNWSTFI PEIISSSKTN ESLCENNMVI LRLLSEEIFN FSEEQMTQTK
     IQTLKITFEK EFSLINDLCF YILENATRAS LIKATLETLQ RFLNWVPLHY IIEVNGGIAE
     PSKLVKLLLH KYFPEPLFRN STLKCLTEIG NLNLGNQQYD AVFIAIIDKF MNQIKFIKPD
     PSKIPQDYED GDQGERSFIH TVSLFLTGFF KSHLKIMENS LNIPYLTLAH EILVNISNID
     ELELFKICLE YWNFLSSNLY SDIATFTTTL LSTPPRLQLY KSVLSKVRVV LIDHMAKPEE
     VIVVEDENGN IVRETTKDTD SLTLYESMRE TLIFLTHLDS ENTQHIMLEK LQTLISGREF
     TFQRLNTLCW AIGSISGAQN KEQEKRFLVT VIKDLLELCQ NKKGKDNKAV IASDIMYIVG
     QYPRFLKDHW KFLKTVVNKL FEFMHESHPG VQDMACDTFL KISKQCKRKF VVLQVEESQP
     FINELLNQLS TTIAHLEQSQ IHTFYEAVGY MIASSSDAAF REKLVNKFME LPNHSWLQIM
     GAASVKVESL LTVEVARDIL NLIKTNNRAA MSLENCYITQ ISKIYLDLLN VYRTYSDHIS
     RNPNIYRETL GQAMRSVKKE TLKLLETFIE KSSDKQVIYS NFLQPLLEAV LGDYRTNIPE
     TRDPEVLSLM TAIITSLKQL VHPEVPKILE AVFETTLSMI TKNFEDYPYH RINFFNLIRA
     INSNAFTVFH NLHPQQFKLL IDCVVWAFKH TERNISETGL HILKELIENV SKNSDVANVF
     FKTYLVSLLN DILYILTDSF HKSGFALECD ILRMMFQVVE NGVVKIPLFD PQQANFPSNS
     EYVKEIVVTF LSASPNVSRP QIQAFVTRLF NLANINNNDF KSATRDFLIT LKEWKSHENA
     DLYSDEKNIE KALALKKQSM IPGMVRPNDV NLEMNDL