ID   XPO2_ARATH              Reviewed;         972 AA.
AC   Q9ZPY7; Q56WE2; Q7GA14;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 147.
DE   RecName: Full=Exportin-2;
DE            Short=Exp2;
DE   AltName: Full=Cellular apoptosis susceptibility protein homolog;
DE   AltName: Full=Importin-alpha re-exporter;
GN   Name=CAS; OrderedLocusNames=At2g46520; ORFNames=F11C10, F13A10.5;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Columbia;
RA   Haasen D., Merkle T.;
RT   "Characterisation of CAS from Arabidopsis thaliana as the nuclear export
RT   receptor for importin alpha.";
RL   Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 638-972.
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Export receptor for importin alpha. Mediates importin-alpha
CC       re-export from the nucleus to the cytoplasm after import substrates
CC       have been released into the nucleoplasm (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds with high affinity to importin-alpha only in the
CC       presence of RanGTP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the XPO2/CSE1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAD95016.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ297282; CAC83300.1; -; mRNA.
DR   EMBL; AC006418; AAD20163.1; -; Genomic_DNA.
DR   EMBL; AC006526; AAM15266.1; -; Genomic_DNA.
DR   EMBL; CP002685; AEC10713.1; -; Genomic_DNA.
DR   EMBL; AK222100; BAD95016.1; ALT_INIT; mRNA.
DR   PIR; H84903; H84903.
DR   RefSeq; NP_182175.1; NM_130217.4.
DR   AlphaFoldDB; Q9ZPY7; -.
DR   SMR; Q9ZPY7; -.
DR   BioGRID; 4598; 2.
DR   STRING; 3702.AT2G46520.1; -.
DR   MetOSite; Q9ZPY7; -.
DR   SwissPalm; Q9ZPY7; -.
DR   PaxDb; Q9ZPY7; -.
DR   PRIDE; Q9ZPY7; -.
DR   ProteomicsDB; 243044; -.
DR   EnsemblPlants; AT2G46520.1; AT2G46520.1; AT2G46520.
DR   GeneID; 819263; -.
DR   Gramene; AT2G46520.1; AT2G46520.1; AT2G46520.
DR   KEGG; ath:AT2G46520; -.
DR   Araport; AT2G46520; -.
DR   TAIR; locus:2039109; AT2G46520.
DR   eggNOG; KOG1992; Eukaryota.
DR   HOGENOM; CLU_009614_0_0_1; -.
DR   InParanoid; Q9ZPY7; -.
DR   OMA; YRYEFKS; -.
DR   OrthoDB; 1248958at2759; -.
DR   PhylomeDB; Q9ZPY7; -.
DR   PRO; PR:Q9ZPY7; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q9ZPY7; baseline and differential.
DR   Genevisible; Q9ZPY7; AT.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR005043; XPO2_C.
DR   InterPro; IPR013713; XPO2_central.
DR   Pfam; PF03378; CAS_CSE1; 1.
DR   Pfam; PF08506; Cse1; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..972
FT                   /note="Exportin-2"
FT                   /id="PRO_0000117291"
FT   DOMAIN          29..104
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
FT   CONFLICT        787
FT                   /note="K -> R (in Ref. 4; BAD95016)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   972 AA;  108657 MW;  A0D9C38E4E1EFBCE CRC64;
     MEWNRETLVF LSQCFLNTLS PIPEPRRTAE RALSDAADQA NYGLAVLRLV AEPAIDEQTR
     HAAAVNFKNH LRSRWHPAGD SGISPIVDSE KEQIKTLIVS LMLSASPRIQ SQLSEALTVI
     GKHDFPKAWP ALLPELIANL QNAALAGDYV SVNGILGTAS SIFKKFSYEY RTDALFVDLK
     YCLDNFAAPL TEIFLKTSSL IDSAASSGGS PPILKPLFES QRLCCTIFYS LNFQDLPEFF
     EDHMKEWMGE FKKYLSSNYP ALESTEEGLT LVDDLRAAIC ENINHYIEKN EEEFQGFLNE
     FASVVWTLLR DVSKSPSRDQ LATTAIKFLT SVSTSVHHAL FAGDNVIKEI CQSIVIPNVS
     LRVEDEEIFE MNYIEFIRRD MEGSDVDTRR RIACELLKGL ATNYKTQVTE VVSLEIQRLL
     SSFSANPSAN WKDKDCAIYL VVSLSTKKAG GASVSTDLID VQNFFANIIL PELQSRDVNS
     FPMLKAGSLK FLTMFRSHIP KPFAMQLFPE LVRFLKAESN VVHSYAASCI EKLLLVKEEG
     ARGNRYAAGD LSPFLLQLMT NLFDALKFPE SEENQYLMKC IMRVLGVADI SAEVAGPCIG
     GLTSILSEVC KNPKNPIFNH YLFESVAVLV RRACERDISL ISAFETSLFP SLQMILANDI
     TEFLPYGFQL LAQLVELNRP TLSPNYMQIF LLLLSPESWK RSGNVPALVR LLQAFLQKAP
     HEVTQENRLS QVLGIFEKLV ASPSTDEQGF YILNTIIENL DYSVIAPYMK GVWSALFTRV
     QNKKTVKFQK SLVIFMSLFL VKHGQAYLVE TMNTVQPNII TAIVEHFWIP NLKLIMGSME
     VKLTAVAATR LICETPALLD PSAAKLWGKM LDSIVTLVSR PEQERVLDEP EMPEISENVG
     YTAAFVKLHN AGKKEEDPLK DIKDPKQFLV ASVSRLSSAS PGRYPQIIGE NLEQANQTAL
     IQLCNAYNCG IA