ID   XPO2_DICDI              Reviewed;         951 AA.
AC   Q54E36;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Exportin-2;
DE            Short=Exp2;
DE   AltName: Full=Importin-alpha re-exporter;
GN   Name=xpo2; ORFNames=DDB_G0291838;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Export receptor for importin alpha. Mediates importin-alpha
CC       re-export from the nucleus to the cytoplasm after import substrates
CC       have been released into the nucleoplasm (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the XPO2/CSE1 family. {ECO:0000305}.
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DR   EMBL; AAFI02000185; EAL61540.1; -; Genomic_DNA.
DR   RefSeq; XP_629951.1; XM_629949.1.
DR   AlphaFoldDB; Q54E36; -.
DR   SMR; Q54E36; -.
DR   STRING; 44689.DDB0191603; -.
DR   PaxDb; Q54E36; -.
DR   EnsemblProtists; EAL61540; EAL61540; DDB_G0291838.
DR   GeneID; 8628357; -.
DR   KEGG; ddi:DDB_G0291838; -.
DR   dictyBase; DDB_G0291838; xpo2.
DR   eggNOG; KOG1992; Eukaryota.
DR   HOGENOM; CLU_009614_0_0_1; -.
DR   InParanoid; Q54E36; -.
DR   OMA; YRYEFKS; -.
DR   PhylomeDB; Q54E36; -.
DR   PRO; PR:Q54E36; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR005043; XPO2_C.
DR   InterPro; IPR013713; XPO2_central.
DR   Pfam; PF03378; CAS_CSE1; 1.
DR   Pfam; PF08506; Cse1; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..951
FT                   /note="Exportin-2"
FT                   /id="PRO_0000342153"
FT   DOMAIN          29..104
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
SQ   SEQUENCE   951 AA;  108134 MW;  3C9BA5CEA730424C CRC64;
     MELPKETIEQ LQNLFIAANR PEKEIREEAT SKIQKFVKET PNSIITLLVF QNLKTIDAGA
     RTLSAITFKN LVKDSWVDGD EVENPIPSND KEMVKSLLLN FILSAVNNTT QSQLVESLSM
     IGVSDFPQQW PSILPELIKQ MESNTDIPTL SIILRVLHSL LKKYRGQERN NQSLSELKYI
     LSILPTPYLS LLIKTGVAVD ANLQNEQQLV LLLNCVHFLL EIFFSMSSVD LPEFFEDNLA
     SFTNEFHRYL KFNTNFQSII LSSNDEEPSL LKKIQTSICE IINLYTQIYD EEFSSFLQPF
     VQVVWGLLTQ TSKDICNDPF VYASIRFLGT VATSISHKIF ESPETLKQIC SMIVTPNIEL
     RESDIELYED NHVEYMRRDI EGSDSDTRRR AAIELVKGLR KYYENQVIQL LSVDINNLLQ
     KYNSNREENW ICKDSAIFLV TALAVKSGGS DESSESSKLV NVLDFFKSSI EPELSGATQT
     NKPILKADCL KFITIFRNQI PAEEYPRILQ SVIPCLENPD FIIHTYASTC IDRLLSVKDG
     GVPRLSAEFI STNLTGLLLP LVGVFNFKDS KQNERAMRTI VRIVLMTQGK VSQQITIQLL
     QKFVSIIIEE AKNPSNHSFN HYCFEVVGTL LKGFSSEPEV TQIIMPLIEM VLQTNNAEFS
     PYCFQLLSIL VENCRPEYLD LFRPILPIIF NDMTWARDAD YPALVRLLQA FIKKEGSSIA
     PHLSAILGIT EKLIMRVTHD HEAFLILETV VETLDIQFLE KYLGGIFSMI LTRITKKKTL
     KVVRCFTIFF SIFMIKYGVV KTAQTVRAIK DSLWEDILIK LWLPTVEDIN GSIEKKIISI
     SLTNMICCND ILATPELWIK LIQCQSNVIS GKKSQETEQA GAASDLYIDQ AEANEGYVPT
     FTQLQFSKKV DVDPFPTISN PKEYFISTFQ TFKSQNEMLV TPLLSTANIQ L