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XPO2_DROME
ID   XPO2_DROME              Reviewed;         975 AA.
AC   Q9XZU1; Q9UB14; Q9VJH4;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 2.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Exportin-2;
DE            Short=Exp2;
DE   AltName: Full=Cellular apoptosis susceptibility protein homolog;
DE   AltName: Full=Chromosome segregation protein 1;
DE   AltName: Full=Importin-alpha re-exporter {ECO:0000305};
GN   Name=Cse1 {ECO:0000312|FlyBase:FBgn0022213};
GN   Synonyms=Cas {ECO:0000303|PubMed:11944946};
GN   ORFNames=CG13281 {ECO:0000312|FlyBase:FBgn0022213};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11944946; DOI=10.1006/dbio.2002.0612;
RA   Tekotte H., Berdnik D., Toeroek T., Buszczak M., Jones L.M., Cooley L.,
RA   Knoblich J.A., Davis I.;
RT   "Dcas is required for importin-alpha3 nuclear export and mechano-sensory
RT   organ cell fate specification in Drosophila.";
RL   Dev. Biol. 244:396-406(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=10731138; DOI=10.1126/science.287.5461.2222;
RA   Rubin G.M., Hong L., Brokstein P., Evans-Holm M., Frise E., Stapleton M.,
RA   Harvey D.A.;
RT   "A Drosophila complementary DNA resource.";
RL   Science 287:2222-2224(2000).
CC   -!- FUNCTION: Export receptor for importin alpha. Mediates importin-alpha
CC       re-export from the nucleus to the cytoplasm after import substrates
CC       have been released into the nucleoplasm (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Binds with high affinity to importin-alpha only in the
CC       presence of RanGTP. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the XPO2/CSE1 family. {ECO:0000305}.
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DR   EMBL; AJ238857; CAB42967.1; -; mRNA.
DR   EMBL; AE014134; AAF53575.1; -; Genomic_DNA.
DR   EMBL; AF132562; AAD27861.1; -; mRNA.
DR   RefSeq; NP_523588.2; NM_078864.3.
DR   AlphaFoldDB; Q9XZU1; -.
DR   SMR; Q9XZU1; -.
DR   BioGRID; 61019; 12.
DR   IntAct; Q9XZU1; 6.
DR   MINT; Q9XZU1; -.
DR   STRING; 7227.FBpp0080484; -.
DR   PaxDb; Q9XZU1; -.
DR   PRIDE; Q9XZU1; -.
DR   EnsemblMetazoa; FBtr0080930; FBpp0080484; FBgn0022213.
DR   GeneID; 35016; -.
DR   KEGG; dme:Dmel_CG13281; -.
DR   CTD; 35016; -.
DR   FlyBase; FBgn0022213; Cse1.
DR   VEuPathDB; VectorBase:FBgn0022213; -.
DR   eggNOG; KOG1992; Eukaryota.
DR   GeneTree; ENSGT00550000074884; -.
DR   HOGENOM; CLU_009614_0_0_1; -.
DR   InParanoid; Q9XZU1; -.
DR   PhylomeDB; Q9XZU1; -.
DR   SignaLink; Q9XZU1; -.
DR   ChiTaRS; caz; fly.
DR   GenomeRNAi; 35016; -.
DR   PRO; PR:Q9XZU1; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0022213; Expressed in eye disc (Drosophila) and 24 other tissues.
DR   Genevisible; Q9XZU1; DM.
DR   GO; GO:0005829; C:cytosol; HDA:FlyBase.
DR   GO; GO:0005635; C:nuclear envelope; HDA:FlyBase.
DR   GO; GO:0005654; C:nucleoplasm; HDA:FlyBase.
DR   GO; GO:0005049; F:nuclear export signal receptor activity; IBA:GO_Central.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006611; P:protein export from nucleus; IMP:FlyBase.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR005043; XPO2_C.
DR   InterPro; IPR013713; XPO2_central.
DR   Pfam; PF03378; CAS_CSE1; 1.
DR   Pfam; PF08506; Cse1; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..975
FT                   /note="Exportin-2"
FT                   /id="PRO_0000117290"
FT   DOMAIN          29..105
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
FT   CONFLICT        194
FT                   /note="K -> T (in Ref. 2; AAF53575)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        331
FT                   /note="Q -> P (in Ref. 1; CAB42967)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        589..590
FT                   /note="AA -> GR (in Ref. 1; CAB42967)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   975 AA;  110168 MW;  5C9BA11C08D49C11 CRC64;
     MEVTEANLQL LAGYLQQTLS ADPNVRRPAE KLLESTELQQ NYPILLLNLI DKAQMDMTTR
     VAGAIAFKNY IKRNWAAHLD SDGPDRIHES DRNTIKTLIV TLMLHSPVAL QKQLSDAVSI
     IGKYDFPKKW PQLIDEMVER FASGDFNVIN GVLQTAHSLF KRYRYEFKSQ ALWEEIKFVL
     DRMAKPLTDL LQAKMQLTKV HENNAGALKV IYGSLVLVNK VFFSLNSQDL PEFFEDNINT
     WMGAFIQQLA ADVPSLRTAD DEDAGVLEHL RAQVCENICL YAKKYDEEFK PFMEQFVTAV
     WELLVKTSLH TKYDSLVSHA LQFLSVVADR QHYQSIFENP EILAQICDKV VIPNLDIRPS
     DEEIFEDSPE EYIRRDIEGS DIDTRRRAAC DLVKTLSINF EQKIFGIFGQ YLERLLTKYK
     ENPATNWRSK DTAIYLVTSW ASRGGTQKHG ITQTSELVPL PEFCAQQIIP ELERPNINEF
     PVLKAAAIKY VMVFRSILGP QVLASCLPQL IRHLPAESSV VHSYAACSVE KILSMRDASN
     AIVFGPQILA PYTTELISGL FATLSLPGSG ENEYVMKAIM RSFSVLQSAA MPFMGVALPR
     LTEILTQVAK NPSRPQFNHY LFETLALCIK IVCHADSSAV SSFEEALFPV FQGILQQDIV
     EFMPYVFQML SVLLEMREGT GTIPEPYWAL FPCLLSPALW DRTGNVTPLI RLISAFIKQG
     SAQIQALGKL SGILGIFQKM IASKANDHEG FYLLQNLLSY YPPAEIQTNL RQIFGLLFQR
     LSLSKTPKYL SGIIIFFSFY VIKFSGSQMA QLIDEIQPNL FGMLLDRVFI TEMGKIPKEQ
     DRKMVAVGVT KLLTETPEIL QQQYATFWPR LLHSLIDLFE RPPEKLMGLE IGETAGVAED
     PDAGYQVAFA QLTHAQPNQQ DHLAEIKDAR QFLATSLSKF AQARAGEFST LLSPLEPEYK
     QVLQKYCDQA GVRIA
 
 
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