ID   XPO2_ORENI              Reviewed;         971 AA.
AC   Q8AY73;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Exportin-2;
DE            Short=Exp2;
DE   AltName: Full=Cellular apoptosis susceptibility protein;
DE   AltName: Full=Chromosome segregation 1-like protein;
DE   AltName: Full=Importin-alpha re-exporter;
GN   Name=cse1l; Synonyms=cas, xpo2;
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Praveen K., Leary J.H. III, Evans D.L., Jaso-Friedmann L.;
RT   "Expression of cellular apoptosis susceptibility protein in non-specific
RT   cytotoxic cells.";
RL   Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Export receptor for importin alpha. Mediates importin-alpha
CC       re-export from the nucleus to the cytoplasm after import substrates
CC       have been released into the nucleoplasm (By similarity). Negatively
CC       regulates fluid secretion and plays a role in fluid homeostasis by
CC       down-regulating cftr activity (By similarity).
CC       {ECO:0000250|UniProtKB:P55060, ECO:0000250|UniProtKB:Q7SZC2}.
CC   -!- SUBUNIT: Interacts with cftr. {ECO:0000250|UniProtKB:Q7SZC2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P55060}. Nucleus
CC       {ECO:0000250|UniProtKB:P55060}. Note=Shuttles between the nucleus and
CC       the cytoplasm. {ECO:0000250|UniProtKB:P55060}.
CC   -!- SIMILARITY: Belongs to the XPO2/CSE1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF547173; AAN52370.1; -; mRNA.
DR   RefSeq; NP_001266624.1; NM_001279695.1.
DR   AlphaFoldDB; Q8AY73; -.
DR   SMR; Q8AY73; -.
DR   STRING; 8128.ENSONIP00000023884; -.
DR   Ensembl; ENSONIT00000051732; ENSONIP00000030576; ENSONIG00000018970.
DR   GeneID; 100534474; -.
DR   KEGG; onl:100534474; -.
DR   CTD; 1434; -.
DR   eggNOG; KOG1992; Eukaryota.
DR   GeneTree; ENSGT00550000074884; -.
DR   HOGENOM; CLU_009614_0_0_1; -.
DR   InParanoid; Q8AY73; -.
DR   OMA; YRYEFKS; -.
DR   OrthoDB; 1248958at2759; -.
DR   Proteomes; UP000005207; Linkage group LG5.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR005043; XPO2_C.
DR   InterPro; IPR013713; XPO2_central.
DR   Pfam; PF03378; CAS_CSE1; 1.
DR   Pfam; PF08506; Cse1; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..971
FT                   /note="Exportin-2"
FT                   /id="PRO_0000237681"
FT   DOMAIN          29..102
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
SQ   SEQUENCE   971 AA;  110233 MW;  7D82A7187F063B30 CRC64;
     MELNDANLQT LTEFLRKTLD PDPTVRRPAE KFLESVEGNQ NYPLLLLTLL EKSQDNVIRV
     CAAVTFKNYI KRNWRIVEDE PNKISDPDRT AVKANIVNLM LSSPEQIQKQ LSDAISIIGR
     EDFPQKWPDL LTEMVARFRS GDFHIINGVL RTAHSLFKRY RHEFKSNELW SEIKLVLDTF
     ALPLTELFKA TIELCQTHAT DVNALKVLFS SLTLIAKLFY SLNFQDLPEF FEDNMETWMT
     NFHGLLTLDN KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQPYL PRFVTAIWNL
     LVSTGQEVKY DLLVSNAIQF LASVCERPHY KHLFEDQNTL TSICEKVIVP NMEFRSADEE
     AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP VTAIFSGYVN SMLSEYAKNP
     RENWKHKDAA IYLVTSLASK AQTQKHGITQ ANELVNLTEF FVNHILPDLK SPNVNEFPVL
     KADAIKYVMI FRSQLPKEQL LQAVPLLITH LQAESTVEHT YAAHALERLF TMRGPNNATL
     ITAAEMAPFT EQLLNNLFKA LAFPGSAENE YIMKAIMRSF SLLQESIVPY IPTLIGQLTH
     KLLQVSKNPS KPHFNHYLFE SLCLSVRITC KANPTTVSSF EEALFPVFTE ILQNDVQEFL
     PYVFQVMSLL LEIHSNSIPA SYMALFPHLL QPVLWERTGN IPPLVRLLQA YLEKGGETIA
     RSAADKIPGL LGVFQKLIAS KANDHQGFYL LNSIIEHMPP ESLTQYRKQI FILLFQRLQS
     SKTTKFIKSF LVFVNLYCVK YGAIALQEIF DSIQPKMFGM VLEKIVIPEV QKVSGPVEKK
     ICAVGITKVL TECPAMMDTE YTKLWTPLLQ ALIGLFELPE DDSIPDDEHF IDIEDTPGYQ
     TAFSQLAFAG KKEHDPIGDA VGNPKILLAQ SLHKLSTACP GRVPSMLSTS LNAEALQFLQ
     GYLQAATVQL V