ID   XPO2_PAGMA              Reviewed;         971 AA.
AC   Q9PTU3;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Exportin-2;
DE            Short=Exp2;
DE   AltName: Full=Cellular apoptosis susceptibility protein;
DE   AltName: Full=Chromosome segregation 1-like protein;
DE   AltName: Full=Importin-alpha re-exporter;
GN   Name=cse1l; Synonyms=cas, xpo2;
OS   Pagrus major (Red sea bream) (Chrysophrys major).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Spariformes; Sparidae; Pagrus.
OX   NCBI_TaxID=143350;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Choi C.Y., Yoshizaki G., Takashima F.;
RT   "Cellular apoptosis susceptibility gene messenger ribonucleic acid in the
RT   ovary of red seabream.";
RL   Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Export receptor for importin alpha. Mediates importin-alpha
CC       re-export from the nucleus to the cytoplasm after import substrates
CC       have been released into the nucleoplasm (By similarity). Negatively
CC       regulates fluid secretion and plays a role in fluid homeostasis by
CC       down-regulating cftr activity (By similarity).
CC       {ECO:0000250|UniProtKB:P55060, ECO:0000250|UniProtKB:Q7SZC2}.
CC   -!- SUBUNIT: Interacts with cftr. {ECO:0000250|UniProtKB:Q7SZC2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P55060}. Nucleus
CC       {ECO:0000250|UniProtKB:P55060}. Note=Shuttles between the nucleus and
CC       the cytoplasm. {ECO:0000250|UniProtKB:P55060}.
CC   -!- SIMILARITY: Belongs to the XPO2/CSE1 family. {ECO:0000305}.
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DR   EMBL; AB036757; BAA89430.1; -; mRNA.
DR   AlphaFoldDB; Q9PTU3; -.
DR   SMR; Q9PTU3; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR005043; XPO2_C.
DR   InterPro; IPR013713; XPO2_central.
DR   Pfam; PF03378; CAS_CSE1; 1.
DR   Pfam; PF08506; Cse1; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Transport.
FT   CHAIN           1..971
FT                   /note="Exportin-2"
FT                   /id="PRO_0000117289"
FT   DOMAIN          29..102
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
SQ   SEQUENCE   971 AA;  109972 MW;  C74E9277C50E5A38 CRC64;
     MELNDANLQT LTEFLRKALD PDPTVRRPAE KFLESVEGNQ NYPLLLLTLL EKSQDNVIRV
     CAAVTFKNYI KRNWRVIEDE PNKVSDPDRT AIKANIVNLM LSSPEQIQKQ LSDAISIIGR
     EDFPQKWPDL LTEMVTRFRS GDFHIINGVL RTAHSLFKRY RHEFKSNELW SEIKLVLDTF
     ALPLTELFKA TIELCQTHAT DVNALKVLFS SLTLISKLFY SLNFQDLPEF FEDNMETWMT
     NFHGLLTLDN KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQPYL PRFVTAIWNL
     LVSTGQEVKY DLLVSNAIQF LASVCERPHY KHLFEDQNTL TSICEKVIVP NMEFRSADEE
     AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP VTAIFSGYVN SMLAEYAKNP
     GENWKHKDAA IYLVTSLASK AQTQKHGITQ ANELVNLNEF FVNHILSDLK SHNVNEFPVL
     KADAIKYVMI FRSQLPKEQL LQAVPLLISH LQAESTVEHT YAAHALERLF TMRGPNNTTL
     ITPVEMAPFT EQLLNNLFKS LALPGSAENE YIMKAIMRTF SLLQEAIVPY IPTLIGQLTH
     KLLLVSKNPS KPHFNHYLFE SLCLSVRITC KANPATVSSF EEALFPVFTE ILQNDVQEFL
     PYVFQVMSLL LEIHSSSIPS SYMALFPHLL QPALWERTGN IPPLVRLLQA YLEKGGATIA
     ASAADKIPGL LGVFQKLIAS KANDHQGFYL LNSIIEHMPP ESITQYRKQI FILLFQRLQS
     SKTTKFIKSF LVFVNLYSVK YGAIALQEIF DSIQPKMFGM VLEKIIIPEV QKVSGAVEKK
     ICAVGITKVL TECPAMMDTE YTKLWTPLLQ ALIGLFELPE DDSIPDDEHF IDIEDTPGYQ
     TAFSQLAFAG KKEHDPIGDA VGNPKILLAQ SLHKLSTACP GRVPSMLSTS LNAEALQFLQ
     GYLQAATVQL V