ID   XPO2_XENLA              Reviewed;         971 AA.
AC   Q6GMY9;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Exportin-2;
DE            Short=Exp2;
DE   AltName: Full=Chromosome segregation 1-like protein;
DE   AltName: Full=Importin-alpha re-exporter;
GN   Name=cse1l; Synonyms=xpo2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Export receptor for importin alpha. Mediates importin-alpha
CC       re-export from the nucleus to the cytoplasm after import substrates
CC       have been released into the nucleoplasm (By similarity).
CC       {ECO:0000250|UniProtKB:P55060}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P55060}. Nucleus
CC       {ECO:0000250|UniProtKB:P55060}. Note=Shuttles between the nucleus and
CC       the cytoplasm. {ECO:0000250|UniProtKB:P55060}.
CC   -!- SIMILARITY: Belongs to the XPO2/CSE1 family. {ECO:0000305}.
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DR   EMBL; BC073735; AAH73735.1; -; mRNA.
DR   RefSeq; NP_001086035.1; NM_001092566.1.
DR   AlphaFoldDB; Q6GMY9; -.
DR   SMR; Q6GMY9; -.
DR   BioGRID; 102627; 1.
DR   IntAct; Q6GMY9; 1.
DR   DNASU; 444464; -.
DR   GeneID; 444464; -.
DR   KEGG; xla:444464; -.
DR   CTD; 444464; -.
DR   Xenbase; XB-GENE-5802416; cse1l.L.
DR   Proteomes; UP000186698; Chromosome 9_10L.
DR   Bgee; 444464; Expressed in ovary and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR005043; XPO2_C.
DR   InterPro; IPR013713; XPO2_central.
DR   Pfam; PF03378; CAS_CSE1; 1.
DR   Pfam; PF08506; Cse1; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..971
FT                   /note="Exportin-2"
FT                   /id="PRO_0000237682"
FT   DOMAIN          29..102
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00115"
SQ   SEQUENCE   971 AA;  109991 MW;  CB602DE60CB64C78 CRC64;
     MELSEGNLQG LTEYLKKTLD PDPAVRRPAE KYLESVEGNQ NYPLLLLTLV ERSQDNVIKV
     CSAVTFKNYI KRNWRIVEDE SNKICEADRI AVKSSIINLM LRSPEQIQKQ LSDAISIIGR
     EDFPQKWPNL LTEMVNRFQS GDFHVINGVL HTAHSLFKRY RHEFKSSELW TEIKLVLDTF
     AGPLTDLFKA TIELCNTHAN DVGALKVLFS SLNLIAKLFH SLNFQDLPEF FEDNMETWMT
     NFHNLLTLDN KLLQTDDEEE AGLLELLKSQ ICDNAALYAQ KYDEEFQPYL PRFVTAIWNL
     LVTTGQEVKY DLLVSNAIQF LASVCERPHY KNLFEDPSTL TSICEKVIVP NMEFRAADEE
     AFEDNSEEYI RRDLEGSDID TRRRAACDLV RGLCKFFEGP VTNIFSGYVN SMLQEYAKNP
     SVNWKHKDAA IYLVTSLASK AQTQKHGITQ ANELVNLTEF FVNHILPDLK SANINQYPVL
     KADGIKYIMF FRSQIPREQL LVTIPLLIAY LQAESIVVHT YAAHALERFF TMKGAATTTL
     IVAADMMPYV ELLLANLFKA LSLPGSTENE YIMKAIMRSF SLLQEAIIPY IPSVISQLTQ
     KLLAVSKNPS KPHFNHYMFE AICLSIRITC RANPAAVASF EDALFLVFTE ILQSDVQEFI
     PYVFQVMSLL LEIHTTDIPP SYMALFPHLL QPVLWERTGN IPPLVRLLQA YLERGATTIA
     ASASDKIPGL LGVFQKLIAS KANDHQGFYL LNSIIEHLPA ECIEQYKRQI FIVLFQRLQS
     SKTTKFVKSF LVFLNLFCIK FGAIALQEMF DSIQPKMFGM VVEKIIIPEI QKVSGPIEKK
     ICAVGLTKVL TECPVMMDTE YTKLWTPLLQ ALIGLFELPE DDTIPDDEHF IDIEDTPGYQ
     AAFSQLAFAG KKEHDPIGEM VNNPKILLAQ SLHKLSTACP GRVPSMISTS LNAEALQFLQ
     GYLQAGSVSL V